ID   MSXB_DANRE              Reviewed;         257 AA.
AC   Q03356; Q503J0; Q5QIA6;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 3.
DT   03-AUG-2022, entry version 145.
DE   RecName: Full=Homeobox protein MSH-B;
GN   Name=msxb; Synonyms=msh-b;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20.
RA   Bai S., Sarras M.P. Jr., Thummel R., Perry M., Godwin A.R.;
RT   "Inhibition of zebrafish fin regeneration using in vivo electroporation of
RT   morpholinos against fgfr1 and msxb.";
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 5-257.
RC   TISSUE=Embryo;
RX   PubMed=7768177; DOI=10.1242/dev.121.2.347;
RA   Akimenko M.-A., Johnson S.L., Westerfield M., Ekker M.;
RT   "Differential induction of four msx homeobox genes during fin development
RT   and regeneration in zebrafish.";
RL   Development 121:347-357(1995).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 138-198.
RX   PubMed=1673109; DOI=10.1016/0378-1119(91)90182-b;
RA   Holland P.W.H.;
RT   "Cloning and evolutionary analysis of msh-like homeobox genes from mouse,
RT   zebrafish and ascidian.";
RL   Gene 98:253-257(1991).
CC   -!- FUNCTION: Probable morphogenetic role.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Msh homeobox family. {ECO:0000305}.
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DR   EMBL; BC095311; AAH95311.1; -; mRNA.
DR   EMBL; AY472118; AAS47685.1; -; Genomic_DNA.
DR   EMBL; U16311; AAA99706.1; -; mRNA.
DR   EMBL; M38579; AAA50032.1; -; Genomic_DNA.
DR   PIR; PS0407; PS0407.
DR   RefSeq; NP_571335.1; NM_131260.1.
DR   AlphaFoldDB; Q03356; -.
DR   SMR; Q03356; -.
DR   STRING; 7955.ENSDARP00000015954; -.
DR   PaxDb; Q03356; -.
DR   Ensembl; ENSDART00000008468; ENSDARP00000015954; ENSDARG00000008886.
DR   GeneID; 30511; -.
DR   KEGG; dre:30511; -.
DR   CTD; 30511; -.
DR   ZFIN; ZDB-GENE-980526-26; msx1b.
DR   eggNOG; KOG0492; Eukaryota.
DR   GeneTree; ENSGT00940000164716; -.
DR   HOGENOM; CLU_072675_1_0_1; -.
DR   InParanoid; Q03356; -.
DR   OMA; AHMGSPT; -.
DR   OrthoDB; 1287272at2759; -.
DR   PhylomeDB; Q03356; -.
DR   TreeFam; TF350699; -.
DR   PRO; PR:Q03356; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 1.
DR   Bgee; ENSDARG00000008886; Expressed in tail bud paraxial mesoderm and 48 other tissues.
DR   ExpressionAtlas; Q03356; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; IDA:ZFIN.
DR   GO; GO:0048598; P:embryonic morphogenesis; IBA:GO_Central.
DR   GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IGI:ZFIN.
DR   GO; GO:0031101; P:fin regeneration; IMP:ZFIN.
DR   GO; GO:0043049; P:otic placode formation; IGI:ZFIN.
DR   GO; GO:0043523; P:regulation of neuron apoptotic process; IGI:ZFIN.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..257
FT                   /note="Homeobox protein MSH-B"
FT                   /id="PRO_0000049067"
FT   DNA_BIND        139..198
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          91..146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..35
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   257 AA;  28756 MW;  3D2F4935A0CDC437 CRC64;
     MNSPKGPVET TSQEKSESDS EESQKPRDMT ADTGHKAKKT YLPFSVESLM AKSSCQQVAC
     SPALQHQRMG HGQDLVRTYF VEKAKVSVDT LSSVSDSLND DSEELSDKEQ STWSNSSSFT
     SPPRHPSPTP CTLRKHKTNR KPRTPFSTSQ LLSLERKFRQ KQYLSIAERA EFSNSLNLTE
     TQVKIWFQNR RAKAKRLQEA ELEKFKCASK PLLAPFALPF PLGSPSSLYG PPASFPRPVP
     MPGLFNGPVS YGMYYLS