ID   MSXC_DANRE              Reviewed;         273 AA.
AC   Q01703;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Homeobox protein MSH-C;
GN   Name=msxc; Synonyms=msh-c;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryo;
RX   PubMed=1352984; DOI=10.1016/0896-6273(92)90217-2;
RA   Ekker M., Akimenko M.-A., Bremiller R., Westerfield M.;
RT   "Regional expression of three homeobox transcripts in the inner ear of
RT   zebrafish embryos.";
RL   Neuron 9:27-35(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 150-210.
RX   PubMed=1673109; DOI=10.1016/0378-1119(91)90182-b;
RA   Holland P.W.H.;
RT   "Cloning and evolutionary analysis of msh-like homeobox genes from mouse,
RT   zebrafish and ascidian.";
RL   Gene 98:253-257(1991).
CC   -!- FUNCTION: Involved in the development of the inner ear.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Msh homeobox family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X65061; CAA46194.1; -; mRNA.
DR   EMBL; M38580; AAA50033.1; -; Genomic_DNA.
DR   PIR; PS0406; PS0406.
DR   PIR; S23281; S23281.
DR   AlphaFoldDB; Q01703; -.
DR   SMR; Q01703; -.
DR   STRING; 7955.ENSDARP00000024644; -.
DR   PaxDb; Q01703; -.
DR   ZFIN; ZDB-GENE-980526-306; msx3.
DR   eggNOG; KOG0492; Eukaryota.
DR   InParanoid; Q01703; -.
DR   PRO; PR:Q01703; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0048598; P:embryonic morphogenesis; IBA:GO_Central.
DR   GO; GO:0043049; P:otic placode formation; IGI:ZFIN.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..273
FT                   /note="Homeobox protein MSH-C"
FT                   /id="PRO_0000049068"
FT   DNA_BIND        151..210
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          114..159
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        20..36
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   273 AA;  30186 MW;  A14C8175D804FABB CRC64;
     MAPLSSMMNS LQGPLSQEGK LQERKSDKED AQSNDKAAVK GCKGKALSLP FSVESLISDR
     TSSRTLYTSS EAGIISPTSG ADERLKLSPM ALYADRKIPV ESVSNLSDCK RGDMEELSDK
     GQSGWFQTTS YTSPPRHSSP PPCTLRKHKN NRKPRTPFTT SQLLALERKF RQKQYLSIAE
     RAEFSNSLNL TETQVKIWFQ NRRAKAKRLQ EAELEKLKLA TKPLLPAFAF PFPLGTHVGS
     PPLYGPSSSF PRPALPVPGL FGGPVTYGMY YLS