ID   MSXD_DANRE              Reviewed;         226 AA.
AC   Q01704;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=Homeobox protein MSH-D;
GN   Name=msxd; Synonyms=msh-d;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Embryo;
RX   PubMed=1352984; DOI=10.1016/0896-6273(92)90217-2;
RA   Ekker M., Akimenko M.-A., Bremiller R., Westerfield M.;
RT   "Regional expression of three homeobox transcripts in the inner ear of
RT   zebrafish embryos.";
RL   Neuron 9:27-35(1992).
CC   -!- FUNCTION: Involved in the development of the inner ear.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Msh homeobox family. {ECO:0000305}.
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DR   EMBL; X65062; CAA46195.1; -; Genomic_DNA.
DR   PIR; S23280; S23280.
DR   AlphaFoldDB; Q01704; -.
DR   SMR; Q01704; -.
DR   STRING; 7955.ENSDARP00000110660; -.
DR   PaxDb; Q01704; -.
DR   Ensembl; ENSDART00000192730; ENSDARP00000157516; ENSDARG00000101023.
DR   ZFIN; ZDB-GENE-980526-492; msx2b.
DR   eggNOG; KOG0492; Eukaryota.
DR   GeneTree; ENSGT00940000164716; -.
DR   InParanoid; Q01704; -.
DR   PhylomeDB; Q01704; -.
DR   PRO; PR:Q01704; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 21.
DR   Bgee; ENSDARG00000101023; Expressed in pharyngeal gill and 26 other tissues.
DR   ExpressionAtlas; Q01704; baseline.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0048598; P:embryonic morphogenesis; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..226
FT                   /note="Homeobox protein MSH-D"
FT                   /id="PRO_0000049069"
FT   DNA_BIND        100..159
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          85..105
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..21
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..39
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   226 AA;  25867 MW;  9BA8B69625F1FFF3 CRC64;
     MEQRKTQVSS HPFSVESLIS SHKTNKDFER RREDVSSQFA QTEIRDSCGS AGIPKHFMLQ
     TSPVKSESPE PDDCTSWVMN SRYSQTRQES PCPLRKHKTN RKPRTPFTTS QLLALERKFR
     QKQYLSIAER AEFSSSLTLT ETQVKIWFQN RRAKAKRLQE AELEKLKLTA KPALHPNFSL
     PLPLGTQLHS AVSLYGQSYP YQRPLLPVAP VGLYGTPLGY SMYHLA