ID   MT12B_DANRE             Reviewed;         477 AA.
AC   Q503M4;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Monocarboxylate transporter 12-B {ECO:0000305};
DE            Short=MCT 12-B {ECO:0000305};
DE   AltName: Full=Solute carrier family 16 member 12-B;
GN   Name=slc16a12b; Synonyms=slc16a12; ORFNames=zgc:110441;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Olfactory epithelium;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Proton-linked monocarboxylate transporter that mediates
CC       creatine transport across the plasma membrane.
CC       {ECO:0000250|UniProtKB:Q6ZSM3}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6ZSM3};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       Monocarboxylate porter (TC 2.A.1.13) family. {ECO:0000305}.
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DR   EMBL; BC095267; AAH95267.1; -; mRNA.
DR   AlphaFoldDB; Q503M4; -.
DR   SMR; Q503M4; -.
DR   STRING; 7955.ENSDARP00000115335; -.
DR   PaxDb; Q503M4; -.
DR   ZFIN; ZDB-GENE-050522-80; slc16a12b.
DR   eggNOG; KOG2504; Eukaryota.
DR   InParanoid; Q503M4; -.
DR   PhylomeDB; Q503M4; -.
DR   PRO; PR:Q503M4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005308; F:creatine transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0008028; F:monocarboxylic acid transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0015881; P:creatine transmembrane transport; ISS:UniProtKB.
DR   GO; GO:0015718; P:monocarboxylic acid transport; IBA:GO_Central.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 2.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome; Symport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..477
FT                   /note="Monocarboxylate transporter 12-B"
FT                   /id="PRO_0000286966"
FT   TOPO_DOM        1..9
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        116..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        253..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        289..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        320..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        344..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        383..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        413..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        434..477
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   477 AA;  51853 MW;  78BF80EC6BDEE490 CRC64;
     MAQEKKKGGV LPPDGGWGWM IVAGCFVVTV CTRAVTRCIS IFFVEFQMHF AKDYSGTAWI
     HSLVDCTTML CAPLGSLIGN QLSCRIAVIL GGFLASVGLV LSSFATSLEY LYATLGLLTG
     LGFALCYTPA IAMVGIYFCE RKALAYGIAM SGSGIGTFIL APVVQLLIEH YSWRGALLIL
     GGFVLNLCVC GALLRPIILK EEEACPLPVD SECGYSVKPP TLNGGPTRSA ASDAKQRCFQ
     SMQEYHFLLM PDFLVLAGSF LLLASGCSLP FVYLVPYALD VGVGHQHAAF LMSILGVIDI
     VGNITFGWLT DRRCLKKYRN ICYMFAVGME GLCCLFIPLL RTFVWLVPFS VLYGYFDGAY
     VALIPVVTSD VVGRQYLSSA LGVVYFLHAV PYLVSPPIGG WLVDTTGTYT ATFFLSGFAL
     ISSSLLLFSV AIIRYCQRNQ KKNSLSKIPK LVSCEGKQVD YYPPKNKDLM LIIPATS