MT1A_ARATH
ID MT1A_ARATH Reviewed; 45 AA.
AC P43392; Q0WLF1;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Metallothionein-like protein 1A;
DE Short=MT-1A;
DE AltName: Full=MT-2;
DE AltName: Full=MT-Q;
DE AltName: Full=Protein LIGHT STRESS-REGULATED 4 {ECO:0000303|PubMed:11683875};
GN Name=MT1A; Synonyms=LSR4 {ECO:0000303|PubMed:11683875};
GN OrderedLocusNames=At1g07600; ORFNames=F22G5_33, F24B9.34;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=7612924; DOI=10.3109/10425179509029353;
RA Yeh S.C., Hsieh H.M., Huang P.C.;
RT "Transcripts of metallothionein genes in Arabidopsis thaliana.";
RL DNA Seq. 5:141-144(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=7565594; DOI=10.1007/bf02191599;
RA Zhou J., Goldsbrough P.B.;
RT "Structure, organization and expression of the metallothionein gene family
RT in Arabidopsis.";
RL Mol. Gen. Genet. 248:318-328(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP INDUCTION.
RX PubMed=11683875; DOI=10.1046/j.1432-1033.2001.02471.x;
RA Dunaeva M., Adamska I.;
RT "Identification of genes expressed in response to light stress in leaves of
RT Arabidopsis thaliana using RNA differential display.";
RL Eur. J. Biochem. 268:5521-5529(2001).
RN [9]
RP TISSUE SPECIFICITY.
RX DOI=10.1046/j.1469-8137.2003.00813.x;
RA Guo W.J., Bundithya W., Goldsbrough P.B.;
RT "Characterization of the Arabidopsis metallothionein gene family: tissue-
RT specific expression and induction during senescence and in response to
RT copper.";
RL New Phytol. 159:369-381(2003).
RN [10]
RP FUNCTION.
RX PubMed=16240177; DOI=10.1007/s11103-005-8268-3;
RA Zimeri A.M., Dhankher O.P., McCaig B., Meagher R.B.;
RT "The plant MT1 metallothioneins are stabilized by binding cadmiums and are
RT required for cadmium tolerance and accumulation.";
RL Plant Mol. Biol. 58:839-855(2005).
RN [11]
RP FUNCTION.
RX PubMed=18287486; DOI=10.1104/pp.108.115782;
RA Guo W.J., Meetam M., Goldsbrough P.B.;
RT "Examining the specific contributions of individual Arabidopsis
RT metallothioneins to copper distribution and metal tolerance.";
RL Plant Physiol. 146:1697-1706(2008).
RN [12]
RP FUNCTION.
RX PubMed=24635746; DOI=10.1111/nph.12718;
RA Benatti M.R., Yookongkaew N., Meetam M., Guo W.J., Punyasuk N.,
RA Abuqamar S., Goldsbrough P.;
RT "Metallothionein deficiency impacts copper accumulation and redistribution
RT in leaves and seeds of Arabidopsis.";
RL New Phytol. 202:940-951(2014).
CC -!- FUNCTION: Metallothioneins have a high content of cysteine residues
CC that bind various heavy metals (Probable). Functions as metal chelator
CC of copper (Cu) and zinc (Zn). Plays a role in Cu homeostasis in the
CC roots under elevated Cu concentration. Functions cooperatively with the
CC phytochelatin synthase PCS1 to protect plants from Cu and cadmium (Cd)
CC toxicity (PubMed:18287486). Plays a role in Cu homeostasis,
CC specifically in the remobilization of Cu from senescing leaves. The
CC mobilization of Cu from internal sources is important for seed
CC development (PubMed:24635746). Confers tolerance to Cd and plays a role
CC in Cd and Zn homeostasis (PubMed:16240177).
CC {ECO:0000269|PubMed:16240177, ECO:0000269|PubMed:18287486,
CC ECO:0000269|PubMed:24635746, ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in phloem and mesophyll cells of leaves,
CC vascular tissues of cotyledons, sepals and petals. Expressed in
CC anthers. Expressed in root endodermis and at lower levels in cortex of
CC mature region of roots. {ECO:0000269|Ref.9}.
CC -!- INDUCTION: By light stress, drought and salt stress.
CC {ECO:0000269|PubMed:11683875}.
CC -!- SIMILARITY: Belongs to the metallothionein superfamily. Type 15 family.
CC {ECO:0000305}.
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DR EMBL; U15130; AAA50251.1; -; mRNA.
DR EMBL; U11253; AAA82209.1; -; Genomic_DNA.
DR EMBL; AC007583; AAF75098.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE28147.1; -; Genomic_DNA.
DR EMBL; AF332449; AAG48812.1; -; mRNA.
DR EMBL; AF386921; AAK62366.1; -; mRNA.
DR EMBL; AY128916; AAM91316.1; -; mRNA.
DR EMBL; AK230254; BAF02056.1; -; mRNA.
DR EMBL; AY086003; AAM63212.1; -; mRNA.
DR PIR; S57858; S57858.
DR RefSeq; NP_172239.1; NM_100633.2.
DR AlphaFoldDB; P43392; -.
DR PaxDb; P43392; -.
DR PRIDE; P43392; -.
DR EnsemblPlants; AT1G07600.1; AT1G07600.1; AT1G07600.
DR GeneID; 837273; -.
DR Gramene; AT1G07600.1; AT1G07600.1; AT1G07600.
DR KEGG; ath:AT1G07600; -.
DR Araport; AT1G07600; -.
DR TAIR; locus:2025082; AT1G07600.
DR eggNOG; KOG4738; Eukaryota.
DR HOGENOM; CLU_3208289_0_0_1; -.
DR PRO; PR:P43392; -.
DR Proteomes; UP000006548; Chromosome 1.
DR Genevisible; P43392; AT.
DR GO; GO:0005507; F:copper ion binding; IDA:TAIR.
DR GO; GO:0046872; F:metal ion binding; TAS:TAIR.
DR GO; GO:0046688; P:response to copper ion; IEP:TAIR.
DR GO; GO:0009644; P:response to high light intensity; IEP:TAIR.
PE 2: Evidence at transcript level;
KW Metal-binding; Metal-thiolate cluster; Reference proteome; Stress response.
FT CHAIN 1..45
FT /note="Metallothionein-like protein 1A"
FT /id="PRO_0000197419"
SQ SEQUENCE 45 AA; 4580 MW; B8AD2C9A030325D2 CRC64;
MADSNCGCGS SCKCGDSCSC EKNYNKECDN CSCGSNCSCG SNCNC
