ID   MT1_CANGA               Reviewed;          63 AA.
AC   P15113; B4UMY6;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Metallothionein-1;
DE            Short=MT-1;
DE   AltName: Full=Metallothionein-I;
DE            Short=MT-I;
GN   Name=MT-I; OrderedLocusNames=CAGL0D01265g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2584191; DOI=10.1016/s0021-9258(19)47175-5;
RA   Mehra R.K., Garey J.R., Butt T.R., Gray W.R., Winge D.R.;
RT   "Candida glabrata metallothioneins. Cloning and sequence of the genes and
RT   characterization of proteins.";
RL   J. Biol. Chem. 264:19747-19753(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
RN   [3]
RP   PROTEIN SEQUENCE OF 2-17.
RX   PubMed=3194392; DOI=10.1073/pnas.85.23.8815;
RA   Mehra R.K., Tarbet B.E., Gray W.R., Winge D.R.;
RT   "Metal-specific synthesis of two metallothioneins and gamma-glutamyl
RT   peptides in Candida glabrata.";
RL   Proc. Natl. Acad. Sci. U.S.A. 85:8815-8819(1988).
CC   -!- FUNCTION: The metallothioneins are involved in the cellular
CC       sequestration of toxic metal ions.
CC   -!- INDUCTION: Both MT-I and MT-II genes are regulated by copper ion in a
CC       concentration-dependent fashion, and both are inducible by silver but
CC       not by cadmium salts.
CC   -!- MISCELLANEOUS: MT-I might bind approximately 11-12 mol eq of Cu(+).
CC   -!- SIMILARITY: Belongs to the metallothionein superfamily. Type 9 family.
CC       {ECO:0000305}.
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DR   EMBL; J05133; AAA35272.1; -; Genomic_DNA.
DR   EMBL; CR380950; CAR58010.1; -; Genomic_DNA.
DR   PIR; A31252; A31252.
DR   PIR; A34484; A34484.
DR   RefSeq; XP_002999527.1; XM_002999481.1.
DR   AlphaFoldDB; P15113; -.
DR   STRING; 5478.XP_002999527.1; -.
DR   PRIDE; P15113; -.
DR   EnsemblFungi; CAR58010; CAR58010; CAGL0D01265g.
DR   GeneID; 9487975; -.
DR   KEGG; cgr:CAGL0D01265g; -.
DR   CGD; CAL0128003; MT-I.
DR   VEuPathDB; FungiDB:CAGL0D01265g; -.
DR   HOGENOM; CLU_2932354_0_0_1; -.
DR   OMA; GDKCECK; -.
DR   Proteomes; UP000002428; Chromosome D.
DR   GO; GO:0005507; F:copper ion binding; IDA:CGD.
DR   GO; GO:0071280; P:cellular response to copper ion; IDA:CGD.
DR   GO; GO:0071292; P:cellular response to silver ion; IDA:CGD.
PE   1: Evidence at protein level;
KW   Copper; Direct protein sequencing; Metal-binding; Metal-thiolate cluster;
KW   Reference proteome; Repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:3194392"
FT   CHAIN           2..63
FT                   /note="Metallothionein-1"
FT                   /id="PRO_0000197365"
FT   REPEAT          23..30
FT   REPEAT          56..63
SQ   SEQUENCE   63 AA;  6374 MW;  80B1FE306C44BAEC CRC64;
     MANDCKCPNG CSCPNCANGG CQCGDKCECK KQSCHGCGEQ CKCGSHGSSC HGSCGCGDKC
     ECK