MT1_DROME
ID MT1_DROME Reviewed; 40 AA.
AC P04357; B5T1U3; B5T1U5; Q9VH67;
DT 20-MAR-1987, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-1987, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Metallothionein-1;
DE Short=MT-1;
GN Name=MtnA; ORFNames=CG9470;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2578462; DOI=10.1016/s0021-9258(18)89624-7;
RA Lastowski-Perry D., Otto E., Maroni G.;
RT "Nucleotide sequence and expression of a Drosophila metallothionein.";
RL J. Biol. Chem. 260:1527-1530(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3086075; DOI=10.2307/3430170;
RA Maroni G., Lastowski-Perry D., Otto E., Watson D.;
RT "Effects of heavy metals on Drosophila larvae and a metallothionein cDNA.";
RL Environ. Health Perspect. 65:107-116(1986).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3007277; DOI=10.1093/genetics/112.3.493;
RA Maroni G., Otto E., Lastowski-Perry D.;
RT "Molecular and cytogenetic characterization of a metallothionein gene of
RT Drosophila.";
RL Genetics 112:493-504(1986).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2822463; DOI=10.1007/978-3-0348-6784-9_36;
RA Maroni G., Otto E., Lastowski-Perry D., Price D.H.;
RT "The metallothionein gene of Drosophila.";
RL Experientia Suppl. 52:385-392(1987).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT LYS-40.
RX PubMed=1802803; DOI=10.1017/s0016672300029955;
RA Theodore L., Ho A.-S., Maroni G.;
RT "Recent evolutionary history of the metallothionein gene Mtn in
RT Drosophila.";
RL Genet. Res. 58:203-210(1991).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT LYS-40.
RC STRAIN=AF6, Canton-S, France, Highgrove, Indiana, LA20, LA66, Taiwan, ZH18,
RC ZH21, ZH27, ZS11, ZS30, and ZS56;
RX PubMed=18670138; DOI=10.1266/ggs.83.265;
RA Kohn M.H., Shapiro J., Wu C.I.;
RT "Decoupled differentiation of gene expression and coding sequence among
RT Drosophila populations.";
RL Genes Genet. Syst. 83:265-273(2008).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [8]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [9]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [10]
RP REGULATION, AND EXPRESSION.
RX PubMed=1976815; DOI=10.1016/s0022-2836(05)80340-7;
RA Silar P., Theodore L., Mokdad R., Erraiss N.-E., Cadic A., Wegnez M.;
RT "Metallothionein Mto gene of Drosophila melanogaster: structure and
RT regulation.";
RL J. Mol. Biol. 215:217-224(1990).
CC -!- FUNCTION: This protein binds cations of several transition elements. It
CC is thought to be involved in detoxification processes.
CC -!- DEVELOPMENTAL STAGE: Late embryogenesis, larva and adult.
CC -!- INDUCTION: Strongly induced by cadmium, copper and mercury.
CC -!- DOMAIN: All cysteine residues are arranged in C-X-C groups. These are
CC thought to be the metal-binding sites in other metallothioneins.
CC -!- SIMILARITY: Belongs to the metallothionein superfamily. Type 5 family.
CC {ECO:0000305}.
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DR EMBL; K02314; AAA28681.1; -; mRNA.
DR EMBL; M27708; AAA28684.1; -; Genomic_DNA.
DR EMBL; X03758; CAA27391.1; -; Genomic_DNA.
DR EMBL; M69015; AAB41334.1; -; Genomic_DNA.
DR EMBL; EU744337; ACH73302.1; -; Genomic_DNA.
DR EMBL; EU744338; ACH73303.1; -; Genomic_DNA.
DR EMBL; EU744339; ACH73304.1; -; Genomic_DNA.
DR EMBL; EU744340; ACH73305.1; -; Genomic_DNA.
DR EMBL; EU744341; ACH73306.1; -; Genomic_DNA.
DR EMBL; EU744342; ACH73307.1; -; Genomic_DNA.
DR EMBL; EU744343; ACH73308.1; -; Genomic_DNA.
DR EMBL; EU744344; ACH73309.1; -; Genomic_DNA.
DR EMBL; EU744345; ACH73310.1; -; Genomic_DNA.
DR EMBL; EU744346; ACH73311.1; -; Genomic_DNA.
DR EMBL; EU744347; ACH73312.1; -; Genomic_DNA.
DR EMBL; EU744348; ACH73313.1; -; Genomic_DNA.
DR EMBL; EU744349; ACH73314.1; -; Genomic_DNA.
DR EMBL; EU744350; ACH73315.1; -; Genomic_DNA.
DR EMBL; AE014297; AAF54452.1; -; Genomic_DNA.
DR EMBL; BT001431; AAN71186.1; -; mRNA.
DR PIR; A25294; SMFF.
DR RefSeq; NP_001262438.1; NM_001275509.1.
DR RefSeq; NP_524299.1; NM_079575.2.
DR AlphaFoldDB; P04357; -.
DR BioGRID; 66359; 10.
DR DIP; DIP-19543N; -.
DR IntAct; P04357; 1.
DR STRING; 7227.FBpp0081636; -.
DR PaxDb; P04357; -.
DR DNASU; 41202; -.
DR EnsemblMetazoa; FBtr0082158; FBpp0081636; FBgn0002868.
DR EnsemblMetazoa; FBtr0334686; FBpp0306744; FBgn0002868.
DR GeneID; 41202; -.
DR KEGG; dme:Dmel_CG9470; -.
DR CTD; 41202; -.
DR FlyBase; FBgn0002868; MtnA.
DR VEuPathDB; VectorBase:FBgn0002868; -.
DR eggNOG; KOG4738; Eukaryota.
DR HOGENOM; CLU_200785_3_0_1; -.
DR InParanoid; P04357; -.
DR OrthoDB; 1637055at2759; -.
DR PhylomeDB; P04357; -.
DR BioGRID-ORCS; 41202; 0 hits in 1 CRISPR screen.
DR ChiTaRS; MtnA; fly.
DR GenomeRNAi; 41202; -.
DR PRO; PR:P04357; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0002868; Expressed in adult Malpighian tubule (Drosophila) and 25 other tissues.
DR ExpressionAtlas; P04357; baseline and differential.
DR Genevisible; P04357; DM.
DR GO; GO:0046872; F:metal ion binding; IDA:FlyBase.
DR GO; GO:0055065; P:metal ion homeostasis; IMP:FlyBase.
DR GO; GO:0010038; P:response to metal ion; IDA:FlyBase.
DR InterPro; IPR000966; Metalthion_5.
DR Pfam; PF02067; Metallothio_5; 1.
DR PRINTS; PR00872; MTDIPTERA.
PE 2: Evidence at transcript level;
KW Cadmium; Copper; Mercury; Metal-binding; Reference proteome; Zinc.
FT CHAIN 1..40
FT /note="Metallothionein-1"
FT /id="PRO_0000197353"
FT VARIANT 40
FT /note="E -> K (in allele MtnA-3 and strain: AF6, Highgrove,
FT Indiana, LA20, Taiwan, ZH18, ZH21, ZH27, ZS11, ZS30 and
FT ZS56)"
FT /evidence="ECO:0000269|PubMed:1802803,
FT ECO:0000269|PubMed:18670138"
SQ SEQUENCE 40 AA; 3853 MW; 99A2A53CCCAE634A CRC64;
MPCPCGSGCK CASQATKGSC NCGSDCKCGG DKKSACGCSE
