ID   MT1_DROSI               Reviewed;          40 AA.
AC   P61874; B4QVX8; P22254;
DT   07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2004, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Metallothionein-1;
DE            Short=MT-1;
GN   Name=MtnA; ORFNames=GD20757;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=1981765; DOI=10.1093/genetics/126.4.921;
RA   Lange B.W., Langley C.H., Stephan W.H.;
RT   "Molecular evolution of Drosophila metallothionein genes.";
RL   Genetics 126:921-932(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=1802803; DOI=10.1017/s0016672300029955;
RA   Theodore L., Ho A.-S., Maroni G.;
RT   "Recent evolutionary history of the metallothionein gene Mtn in
RT   Drosophila.";
RL   Genet. Res. 58:203-210(1991).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: This protein binds cations of several transition elements. It
CC       is thought to be involved in detoxification processes.
CC   -!- DEVELOPMENTAL STAGE: Late embryogenesis, larva and adult.
CC   -!- INDUCTION: Strongly induced by cadmium, copper and mercury.
CC   -!- DOMAIN: All cysteine residues are arranged in C-X-C groups. These are
CC       thought to be the metal-binding sites in other metallothioneins.
CC   -!- SIMILARITY: Belongs to the metallothionein superfamily. Type 5 family.
CC       {ECO:0000305}.
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DR   EMBL; M55407; AAA03345.1; -; Unassigned_DNA.
DR   EMBL; M69016; AAA19877.1; -; Unassigned_DNA.
DR   EMBL; CM000364; EDX13558.1; -; Genomic_DNA.
DR   PIR; B61194; B61194.
DR   RefSeq; XP_002104055.1; XM_002104019.2.
DR   AlphaFoldDB; P61874; -.
DR   EnsemblMetazoa; FBtr0220667; FBpp0219159; FBgn0012845.
DR   GeneID; 6728719; -.
DR   HOGENOM; CLU_200785_3_0_1; -.
DR   PhylomeDB; P61874; -.
DR   ChiTaRS; MtnA; fly.
DR   Proteomes; UP000000304; Chromosome 3r.
DR   Bgee; FBgn0012845; Expressed in adult organism and 3 other tissues.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0055065; P:metal ion homeostasis; IEA:EnsemblMetazoa.
DR   GO; GO:0010038; P:response to metal ion; IEA:EnsemblMetazoa.
DR   InterPro; IPR000966; Metalthion_5.
DR   Pfam; PF02067; Metallothio_5; 1.
DR   PRINTS; PR00872; MTDIPTERA.
PE   2: Evidence at transcript level;
KW   Cadmium; Copper; Metal-binding; Reference proteome; Zinc.
FT   CHAIN           1..40
FT                   /note="Metallothionein-1"
FT                   /id="PRO_0000197354"
SQ   SEQUENCE   40 AA;  3852 MW;  9182A53CCCAE634A CRC64;
     MPCPCGSGCK CASQATKGSC NCGSDCKCGG DKKSACGCSK