ID   MT1_TETPY               Reviewed;         107 AA.
AC   O97388;
DT   09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Metallothionein-1;
DE            Short=MT-1;
DE   Contains:
DE     RecName: Full=Metallothionein-2;
DE              Short=MT-2;
DE   Flags: Precursor;
OS   Tetrahymena pyriformis.
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=5908;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=GL;
RX   PubMed=10393238; DOI=10.1016/s0378-1119(99)00181-x;
RA   Piccinni E., Bertaggia D., Santovito G., Miceli C., Kraev A.;
RT   "Cadmium metallothionein gene of Tetrahymena pyriformis.";
RL   Gene 234:51-59(1999).
RN   [2]
RP   PROTEIN SEQUENCE OF 3-107.
RX   PubMed=7813475; DOI=10.1111/j.1432-1033.1994.t01-1-00853.x;
RA   Piccinni E., Staudenmann W., Albergoni V., de Gabrieli R., James P.;
RT   "Purification and primary structure of metallothioneins induced by cadmium
RT   in the protists Tetrahymena pigmentosa and Tetrahymena pyriformis.";
RL   Eur. J. Biochem. 226:853-859(1994).
CC   -!- FUNCTION: The metallothioneins are involved in the cellular
CC       sequestration of toxic metal ions. Binds 12 cadmium ions per molecule.
CC   -!- INDUCTION: By cadmium.
CC   -!- SIMILARITY: Belongs to the metallothionein superfamily. Type 7 family.
CC       {ECO:0000305}.
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DR   EMBL; AJ005080; CAA06337.1; -; Genomic_DNA.
DR   AlphaFoldDB; O97388; -.
DR   PRIDE; O97388; -.
DR   GO; GO:0046870; F:cadmium ion binding; IEA:InterPro.
DR   InterPro; IPR012484; Metalthion_7.
DR   Pfam; PF07846; Metallothio_Cad; 2.
PE   1: Evidence at protein level;
KW   Cadmium; Direct protein sequencing; Metal-binding; Metal-thiolate cluster.
FT   PROPEP          1..2
FT                   /evidence="ECO:0000269|PubMed:7813475"
FT                   /id="PRO_0000018670"
FT   CHAIN           3..107
FT                   /note="Metallothionein-1"
FT                   /id="PRO_0000018671"
FT   CHAIN           4..107
FT                   /note="Metallothionein-2"
FT                   /id="PRO_0000018672"
SQ   SEQUENCE   107 AA;  11097 MW;  5ABE87BDDA8E465C CRC64;
     MDKVNNNCCC GENAKPCCTD PNSGCCCVSE TNNCCKSDKK ECCTGTGEGC KCTGCKCCEP
     AKSGCCCGDK AKACCTDPNS GCCCSSKTNK CCDSTNKTEC KTCECCK