MT21C_BOVIN
ID MT21C_BOVIN Reviewed; 257 AA.
AC A6QP81;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Protein-lysine methyltransferase METTL21C;
DE EC=2.1.1.-;
DE AltName: Full=Methyltransferase-like protein 21C;
GN Name=METTL21C;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal muscle;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Protein-lysine methyltransferase. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with members of the heat shock protein 70 families;
CC these proteins may possibly be methylation substrates for the enzyme.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. METTL21
CC family. {ECO:0000305}.
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DR EMBL; BC149196; AAI49197.1; -; mRNA.
DR RefSeq; NP_001093853.1; NM_001100383.1.
DR RefSeq; XP_010809264.1; XM_010810962.2.
DR AlphaFoldDB; A6QP81; -.
DR SMR; A6QP81; -.
DR STRING; 9913.ENSBTAP00000027181; -.
DR PaxDb; A6QP81; -.
DR Ensembl; ENSBTAT00000027181; ENSBTAP00000027181; ENSBTAG00000020393.
DR GeneID; 519447; -.
DR KEGG; bta:519447; -.
DR CTD; 196541; -.
DR VEuPathDB; HostDB:ENSBTAG00000020393; -.
DR VGNC; VGNC:31407; METTL21C.
DR eggNOG; KOG2793; Eukaryota.
DR GeneTree; ENSGT00940000156596; -.
DR HOGENOM; CLU_055721_0_0_1; -.
DR InParanoid; A6QP81; -.
DR OMA; AYLCQPG; -.
DR OrthoDB; 1494909at2759; -.
DR TreeFam; TF354267; -.
DR Proteomes; UP000009136; Chromosome 12.
DR Bgee; ENSBTAG00000020393; Expressed in gluteus medius and 23 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0031072; F:heat shock protein binding; IEA:Ensembl.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; ISS:UniProtKB.
DR GO; GO:0018022; P:peptidyl-lysine methylation; IBA:GO_Central.
DR GO; GO:0018023; P:peptidyl-lysine trimethylation; IBA:GO_Central.
DR GO; GO:0006479; P:protein methylation; ISS:UniProtKB.
DR Gene3D; 3.40.50.150; -; 1.
DR InterPro; IPR019410; Methyltransf_16.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR14614; PTHR14614; 1.
DR Pfam; PF10294; Methyltransf_16; 1.
DR SUPFAM; SSF53335; SSF53335; 1.
PE 2: Evidence at transcript level;
KW Methyltransferase; Nucleus; Reference proteome; S-adenosyl-L-methionine;
KW Transferase.
FT CHAIN 1..257
FT /note="Protein-lysine methyltransferase METTL21C"
FT /id="PRO_0000319589"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 85
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000250"
FT BINDING 113..115
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000250"
FT BINDING 134
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000250"
FT BINDING 165
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000250"
SQ SEQUENCE 257 AA; 28904 MW; 166916B792723AE0 CRC64;
MDACLSSEQQ PRPLDEGPSP PDNEALHTDG TSKRPGDSNE IEASLRSLQK FVPTNYASYT
QEYYRFVGKK IVIQESIESY GAVVWPGAMA LCQYLEEHTE ELNLRGAKIL EIGAGPGLVS
IVASILGAQV TATDLPDVLG NLQYNLLKNT LNCTTYLPEV KELVWGEGLE QSFPKSTLYY
DYVLASDVVY HHYFLDKLLA TMVYLCQPGT VLLWANKFRF STDYEFLDKF KQVFDTTLLA
ESQESSIKLF KGILKWD
