MT21E_BOVIN
ID MT21E_BOVIN Reviewed; 290 AA.
AC Q58DC7; A6QQG3;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Protein-lysine methyltransferase METTL21E;
DE EC=2.1.1.-;
DE AltName: Full=Methyltransferase-like protein 21E;
GN Name=METTL21E;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal muscle;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Protein-lysine methyltransferase. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. METTL21
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BT021670; AAX46517.1; -; mRNA.
DR EMBL; BC149818; AAI49819.1; -; mRNA.
DR RefSeq; NP_001014922.1; NM_001014922.1.
DR AlphaFoldDB; Q58DC7; -.
DR SMR; Q58DC7; -.
DR STRING; 9913.ENSBTAP00000001770; -.
DR PaxDb; Q58DC7; -.
DR GeneID; 513822; -.
DR KEGG; bta:513822; -.
DR CTD; 403183; -.
DR eggNOG; KOG2793; Eukaryota.
DR HOGENOM; CLU_055721_0_0_1; -.
DR InParanoid; Q58DC7; -.
DR OrthoDB; 1494909at2759; -.
DR TreeFam; TF354267; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; -; 1.
DR InterPro; IPR019410; Methyltransf_16.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR14614; PTHR14614; 1.
DR Pfam; PF10294; Methyltransf_16; 1.
DR SUPFAM; SSF53335; SSF53335; 1.
PE 2: Evidence at transcript level;
KW Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW Transferase.
FT CHAIN 1..290
FT /note="Protein-lysine methyltransferase METTL21E"
FT /id="PRO_0000329290"
FT BINDING 96
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000250"
FT BINDING 124..126
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000250"
FT BINDING 145
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000250"
FT BINDING 176
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000250"
FT BINDING 197
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000250"
FT CONFLICT 45
FT /note="R -> G (in Ref. 2; AAI49819)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 290 AA; 33336 MW; EE2E577D484444AA CRC64;
MILFNLLETQ LTRVHSFQEM IKKASVYRHP LANHLMDPEV QKESREDGDD RTVVAEIMRR
CFVPAFVTTI PWEGFHFAGH EIRINEATDC YGAVVWPSAL VLCYFLETNV KQYNLVDKNV
IEIGAGTGLV SIVASLLGAH VTATDLPELL GNLQYNISRN TKTKAKHLPQ VKELSWGVAL
DKNFPRASIN FDYILAADVV YAHPFLEELL VTFDHLCKET TVILWVMKFR LEKENKFVDR
FEQLFDLEEI SSFPSLNIKL YKAMKKNQKS ACYPQRRMWK AKPISGRLLL
