MT21_CAEEL
ID MT21_CAEEL Reviewed; 206 AA.
AC A7IQW5; A3QMC4;
DT 09-JAN-2013, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Protein-lysine methyltransferase C42C1.13;
DE EC=2.1.1.-;
GN ORFNames=C42C1.13;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION.
RX PubMed=22948820; DOI=10.1038/ncomms2041;
RA Kernstock S., Davydova E., Jakobsson M., Moen A., Pettersen S.,
RA Maelandsmo G.M., Egge-Jacobsen W., Falnes P.O.;
RT "Lysine methylation of VCP by a member of a novel human protein
RT methyltransferase family.";
RL Nat. Commun. 3:1038-1038(2012).
CC -!- FUNCTION: Protein-lysine N-methyltransferase.
CC {ECO:0000269|PubMed:22948820}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=b;
CC IsoId=A7IQW5-1; Sequence=Displayed;
CC Name=a;
CC IsoId=A7IQW5-2; Sequence=VSP_044622;
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. METTL21
CC family. {ECO:0000305}.
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DR EMBL; CU457741; CAO82033.1; -; Genomic_DNA.
DR EMBL; CU457741; CAM36356.1; -; Genomic_DNA.
DR RefSeq; NP_001122759.1; NM_001129287.2. [A7IQW5-1]
DR RefSeq; NP_502334.2; NM_069933.5. [A7IQW5-2]
DR AlphaFoldDB; A7IQW5; -.
DR SMR; A7IQW5; -.
DR STRING; 6239.C42C1.13b; -.
DR PaxDb; A7IQW5; -.
DR PeptideAtlas; A7IQW5; -.
DR EnsemblMetazoa; C42C1.13a.1; C42C1.13a.1; WBGene00016591. [A7IQW5-2]
DR EnsemblMetazoa; C42C1.13b.1; C42C1.13b.1; WBGene00016591. [A7IQW5-1]
DR GeneID; 178175; -.
DR KEGG; cel:CELE_C42C1.13; -.
DR UCSC; C42C1.13b; c. elegans.
DR CTD; 178175; -.
DR WormBase; C42C1.13a; CE39692; WBGene00016591; -. [A7IQW5-2]
DR WormBase; C42C1.13b; CE41367; WBGene00016591; -. [A7IQW5-1]
DR eggNOG; KOG2793; Eukaryota.
DR GeneTree; ENSGT00940000157135; -.
DR InParanoid; A7IQW5; -.
DR OMA; MGAYSGP; -.
DR OrthoDB; 1494909at2759; -.
DR PhylomeDB; A7IQW5; -.
DR Reactome; R-CEL-8876725; Protein methylation.
DR PRO; PR:A7IQW5; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00016591; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IBA:GO_Central.
DR GO; GO:0018022; P:peptidyl-lysine methylation; IBA:GO_Central.
DR GO; GO:0018023; P:peptidyl-lysine trimethylation; IBA:GO_Central.
DR Gene3D; 3.40.50.150; -; 1.
DR InterPro; IPR019410; Methyltransf_16.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR14614; PTHR14614; 1.
DR Pfam; PF10294; Methyltransf_16; 1.
DR SUPFAM; SSF53335; SSF53335; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Methyltransferase; Reference proteome;
KW S-adenosyl-L-methionine; Transferase.
FT CHAIN 1..206
FT /note="Protein-lysine methyltransferase C42C1.13"
FT /id="PRO_0000420713"
FT BINDING 35
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000250"
FT BINDING 61..63
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000250"
FT BINDING 82
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000250"
FT BINDING 112
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..39
FT /note="Missing (in isoform a)"
FT /evidence="ECO:0000305"
FT /id="VSP_044622"
SQ SEQUENCE 206 AA; 23256 MW; 192459201906F7EA CRC64;
MAESEEYARV ISFNNDHDEL IIYQETVTDV GGVIWDSALM TIHYFFKYPK PFEGKKVLEL
GSGTGVGGIA LAALGADVII TDLPERLALI EKNVEANRKL TGNRIKVQVL DWTKDRIPEG
LDMVLAIDCV YYNSTIDPLI TLLNDCDAKE IMVVSEERDI GEAHLAQKSF FKDIQKFFRL
ELIPQKELDE DYCADDIIIG KLIRNV
