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MT22_MYTED
ID   MT22_MYTED              Reviewed;          72 AA.
AC   P80252;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Metallothionein 20-II;
DE            Short=MT-20-II;
OS   Mytilus edulis (Blue mussel).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC   Autobranchia; Pteriomorphia; Mytilida; Mytiloidea; Mytilidae; Mytilinae;
OC   Mytilus.
OX   NCBI_TaxID=6550;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Digestive gland;
RX   PubMed=10190057; DOI=10.1016/s0742-8413(98)10126-3;
RA   Barsyte D., White K.N., Lovejoy D.A.;
RT   "Cloning and characterization of metallothionein cDNAs in the mussel
RT   Mytilus edulis L. digestive gland.";
RL   Comp. Biochem. Physiol. 122C:287-296(1999).
RN   [2]
RP   PROTEIN SEQUENCE OF 2-72.
RX   PubMed=8243463; DOI=10.1111/j.1432-1033.1993.tb18364.x;
RA   Mackay E.A., Overnell J., Dunbar B., Davidson I., Hunziker P.E.,
RA   Kaegi J.H.R., Fothergill J.E.;
RT   "Complete amino acid sequences of five dimeric and four monomeric forms of
RT   metallothionein from the edible mussel Mytilus edulis.";
RL   Eur. J. Biochem. 218:183-194(1993).
CC   -!- FUNCTION: The metallothioneins are involved in the cellular
CC       sequestration of toxic metal ions.
CC   -!- SUBUNIT: Homodimer.
CC   -!- INDUCTION: By cadmium.
CC   -!- SIMILARITY: Belongs to the metallothionein superfamily. Type 2 family.
CC       {ECO:0000305}.
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DR   EMBL; AJ005456; CAA06553.1; -; mRNA.
DR   PIR; S39421; S39421.
DR   AlphaFoldDB; P80252; -.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR001008; Metalthion_mollusc.
DR   PRINTS; PR00875; MTMOLLUSC.
PE   1: Evidence at protein level;
KW   Cadmium; Direct protein sequencing; Metal-binding; Metal-thiolate cluster.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:8243463"
FT   CHAIN           2..72
FT                   /note="Metallothionein 20-II"
FT                   /id="PRO_0000197330"
FT   BINDING         15
FT                   /ligand="Cd(2+)"
FT                   /ligand_id="ChEBI:CHEBI:48775"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P33187"
FT   BINDING         19
FT                   /ligand="Cd(2+)"
FT                   /ligand_id="ChEBI:CHEBI:48775"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P33187"
FT   BINDING         19
FT                   /ligand="Cd(2+)"
FT                   /ligand_id="ChEBI:CHEBI:48775"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P33187"
FT   BINDING         24
FT                   /ligand="Cd(2+)"
FT                   /ligand_id="ChEBI:CHEBI:48775"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P33187"
FT   BINDING         26
FT                   /ligand="Cd(2+)"
FT                   /ligand_id="ChEBI:CHEBI:48775"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000250|UniProtKB:P33187"
FT   BINDING         30
FT                   /ligand="Cd(2+)"
FT                   /ligand_id="ChEBI:CHEBI:48775"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000250|UniProtKB:P33187"
FT   BINDING         32
FT                   /ligand="Cd(2+)"
FT                   /ligand_id="ChEBI:CHEBI:48775"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P33187"
FT   BINDING         32
FT                   /ligand="Cd(2+)"
FT                   /ligand_id="ChEBI:CHEBI:48775"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000250|UniProtKB:P33187"
FT   BINDING         36
FT                   /ligand="Cd(2+)"
FT                   /ligand_id="ChEBI:CHEBI:48775"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P33187"
FT   BINDING         38
FT                   /ligand="Cd(2+)"
FT                   /ligand_id="ChEBI:CHEBI:48775"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P33187"
FT   BINDING         41
FT                   /ligand="Cd(2+)"
FT                   /ligand_id="ChEBI:CHEBI:48775"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P33187"
FT   BINDING         41
FT                   /ligand="Cd(2+)"
FT                   /ligand_id="ChEBI:CHEBI:48775"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000250|UniProtKB:P33187"
FT   BINDING         45
FT                   /ligand="Cd(2+)"
FT                   /ligand_id="ChEBI:CHEBI:48775"
FT                   /ligand_label="4"
FT                   /evidence="ECO:0000250|UniProtKB:P33187"
FT   BINDING         47
FT                   /ligand="Cd(2+)"
FT                   /ligand_id="ChEBI:CHEBI:48775"
FT                   /ligand_label="5"
FT                   /evidence="ECO:0000250|UniProtKB:P33187"
FT   BINDING         51
FT                   /ligand="Cd(2+)"
FT                   /ligand_id="ChEBI:CHEBI:48775"
FT                   /ligand_label="5"
FT                   /evidence="ECO:0000250|UniProtKB:P33187"
FT   BINDING         53
FT                   /ligand="Cd(2+)"
FT                   /ligand_id="ChEBI:CHEBI:48775"
FT                   /ligand_label="5"
FT                   /evidence="ECO:0000250|UniProtKB:P33187"
FT   BINDING         53
FT                   /ligand="Cd(2+)"
FT                   /ligand_id="ChEBI:CHEBI:48775"
FT                   /ligand_label="6"
FT                   /evidence="ECO:0000250|UniProtKB:P33187"
FT   BINDING         57
FT                   /ligand="Cd(2+)"
FT                   /ligand_id="ChEBI:CHEBI:48775"
FT                   /ligand_label="4"
FT                   /evidence="ECO:0000250|UniProtKB:P33187"
FT   BINDING         57
FT                   /ligand="Cd(2+)"
FT                   /ligand_id="ChEBI:CHEBI:48775"
FT                   /ligand_label="5"
FT                   /evidence="ECO:0000250|UniProtKB:P33187"
FT   BINDING         63
FT                   /ligand="Cd(2+)"
FT                   /ligand_id="ChEBI:CHEBI:48775"
FT                   /ligand_label="4"
FT                   /evidence="ECO:0000250|UniProtKB:P33187"
FT   BINDING         65
FT                   /ligand="Cd(2+)"
FT                   /ligand_id="ChEBI:CHEBI:48775"
FT                   /ligand_label="6"
FT                   /evidence="ECO:0000250|UniProtKB:P33187"
FT   BINDING         69
FT                   /ligand="Cd(2+)"
FT                   /ligand_id="ChEBI:CHEBI:48775"
FT                   /ligand_label="6"
FT                   /evidence="ECO:0000250|UniProtKB:P33187"
FT   BINDING         71
FT                   /ligand="Cd(2+)"
FT                   /ligand_id="ChEBI:CHEBI:48775"
FT                   /ligand_label="4"
FT                   /evidence="ECO:0000250|UniProtKB:P33187"
FT   BINDING         71
FT                   /ligand="Cd(2+)"
FT                   /ligand_id="ChEBI:CHEBI:48775"
FT                   /ligand_label="6"
FT                   /evidence="ECO:0000250|UniProtKB:P33187"
SQ   SEQUENCE   72 AA;  7018 MW;  89EB2A9800857632 CRC64;
     MPGPCNCIET NVCICGTGCS GKCCRCGDAC KCASGCGCSG CKVVCKCSGT CACGCDCTGP
     TNCKCESGCS CK
 
 
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