MT2_CAEEL
ID MT2_CAEEL Reviewed; 63 AA.
AC P17512;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Metallothionein-2;
DE Short=MT-2;
DE AltName: Full=MT-Ce;
DE AltName: Full=Metallothionein-II;
DE Short=MT-II;
DE AltName: Full=Metallothionein-like protein;
GN Name=mtl-2; Synonyms=met-2; ORFNames=T08G5.10;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2294106; DOI=10.1016/s0021-9258(19)40224-x;
RA Slice L.W., Freedman J.H., Rubin C.S.;
RT "Purification, characterization, and cDNA cloning of a novel
RT metallothionein-like, cadmium-binding protein from Caenorhabditis
RT elegans.";
RL J. Biol. Chem. 265:256-263(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 2-15.
RC STRAIN=Bristol N2;
RX PubMed=2344361; DOI=10.1042/bj2680237;
RA Imagawa M., Onozawa T., Okumura K., Osada S., Nishihara T., Kondo M.;
RT "Characterization of metallothionein cDNAs induced by cadmium in the
RT nematode Caenorhabditis elegans.";
RL Biochem. J. 268:237-240(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8428932; DOI=10.1016/s0021-9258(18)53810-2;
RA Freedman J.H., Slice L.W., Dixon D., Fire A., Rubin C.S.;
RT "The novel metallothionein genes of Caenorhabditis elegans. Structural
RT organization and inducible, cell-specific expression.";
RL J. Biol. Chem. 268:2554-2564(1993).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7848551;
RA Kugawa F., Yamamoto H., Osada S., Aoki M., Imagawa M., Nishihara T.;
RT "Metallothionein genes in the nematode Caenorhabditis elegans and metal
RT inducibility in mammalian culture cells.";
RL Biomed. Environ. Sci. 7:222-231(1994).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: This protein binds cations of several transition elements.
CC -!- INDUCTION: By cadmium.
CC -!- DOMAIN: All cysteine residues are arranged in C-X-C groups. These are
CC thought to be the metal-binding sites in other metallothioneins.
CC -!- SIMILARITY: Belongs to the metallothionein superfamily. Type 6 family.
CC {ECO:0000305}.
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DR EMBL; M32386; AAA28117.1; -; mRNA.
DR EMBL; M32387; AAA28118.1; -; mRNA.
DR EMBL; X53245; CAA37335.1; -; mRNA.
DR EMBL; M92910; AAA28111.1; -; Genomic_DNA.
DR EMBL; D17365; BAA04181.1; -; Genomic_DNA.
DR EMBL; Z81589; CAB61028.1; -; Genomic_DNA.
DR PIR; A45206; A34905.
DR RefSeq; NP_506482.1; NM_074081.5.
DR AlphaFoldDB; P17512; -.
DR BioGRID; 44911; 4.
DR STRING; 6239.T08G5.10; -.
DR PaxDb; P17512; -.
DR PeptideAtlas; P17512; -.
DR EnsemblMetazoa; T08G5.10.1; T08G5.10.1; WBGene00003474.
DR GeneID; 179899; -.
DR KEGG; cel:CELE_T08G5.10; -.
DR UCSC; R05D3.11; c. elegans.
DR CTD; 179899; -.
DR WormBase; T08G5.10; CE25109; WBGene00003474; mtl-2.
DR eggNOG; KOG4738; Eukaryota.
DR GeneTree; ENSGT00970000198152; -.
DR HOGENOM; CLU_199958_0_0_1; -.
DR InParanoid; P17512; -.
DR OMA; CANCECA; -.
DR OrthoDB; 1883167at2759; -.
DR PRO; PR:P17512; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00003474; Expressed in adult organism and 4 other tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR000853; Metalthion_nemt.
DR PRINTS; PR00876; MTNEMATODE.
PE 1: Evidence at protein level;
KW Cadmium; Direct protein sequencing; Metal-binding; Metal-thiolate cluster;
KW Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:2344361"
FT CHAIN 2..63
FT /note="Metallothionein-2"
FT /id="PRO_0000197359"
SQ SEQUENCE 63 AA; 6594 MW; 5D55EF8A1CBDFADA CRC64;
MVCKCDCKNQ NCSCNTGTKD CDCSDAKCCE QYCCPTASEK KCCKSGCAGG CKCANCECAQ
AAH
