ID   MT3_DROME               Reviewed;          43 AA.
AC   Q9VDN2;
DT   05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Metallothionein-3;
DE            Short=MT-3;
DE   AltName: Full=Metallothionein C;
GN   Name=MtnC; ORFNames=CG5097;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=12505988; DOI=10.1093/emboj/cdg012;
RA   Egli D., Selvaraj A., Yepiskoposyan H., Zhang B., Hafen E., Georgiev O.,
RA   Schaffner W.;
RT   "Knockout of 'metal-responsive transcription factor' MTF-1 in Drosophila by
RT   homologous recombination reveals its central role in heavy metal
RT   homeostasis.";
RL   EMBO J. 22:100-108(2003).
CC   -!- FUNCTION: This protein binds cations of several transition elements.
CC       Thought to be involved in metal ion homeostasis (By similarity).
CC       {ECO:0000250}.
CC   -!- DOMAIN: All cysteine residues are arranged in C-X-C groups. These are
CC       thought to be the metal-binding sites in other metallothioneins.
CC   -!- SIMILARITY: Belongs to the metallothionein superfamily. Type 5 family.
CC       {ECO:0000305}.
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DR   EMBL; AE014297; AAF55758.1; -; Genomic_DNA.
DR   RefSeq; NP_650882.1; NM_142625.2.
DR   AlphaFoldDB; Q9VDN2; -.
DR   STRING; 7227.FBpp0083292; -.
DR   PaxDb; Q9VDN2; -.
DR   DNASU; 42416; -.
DR   EnsemblMetazoa; FBtr0083884; FBpp0083292; FBgn0038790.
DR   GeneID; 42416; -.
DR   KEGG; dme:Dmel_CG5097; -.
DR   CTD; 42416; -.
DR   FlyBase; FBgn0038790; MtnC.
DR   VEuPathDB; VectorBase:FBgn0038790; -.
DR   eggNOG; KOG4738; Eukaryota.
DR   HOGENOM; CLU_217426_0_0_1; -.
DR   InParanoid; Q9VDN2; -.
DR   OrthoDB; 1625823at2759; -.
DR   PhylomeDB; Q9VDN2; -.
DR   BioGRID-ORCS; 42416; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 42416; -.
DR   PRO; PR:Q9VDN2; -.
DR   Proteomes; UP000000803; Chromosome 3R.
DR   Bgee; FBgn0038790; Expressed in Malpighian tubule and 13 other tissues.
DR   ExpressionAtlas; Q9VDN2; baseline and differential.
DR   Genevisible; Q9VDN2; DM.
DR   GO; GO:0046872; F:metal ion binding; IDA:FlyBase.
DR   GO; GO:0055065; P:metal ion homeostasis; IMP:FlyBase.
DR   GO; GO:0010038; P:response to metal ion; IDA:FlyBase.
DR   InterPro; IPR000966; Metalthion_5.
DR   Pfam; PF02067; Metallothio_5; 1.
DR   PRINTS; PR00872; MTDIPTERA.
PE   3: Inferred from homology;
KW   Cadmium; Copper; Metal-binding; Reference proteome; Zinc.
FT   CHAIN           1..43
FT                   /note="Metallothionein-3"
FT                   /id="PRO_0000197356"
SQ   SEQUENCE   43 AA;  4597 MW;  E54E722B14E89DFE CRC64;
     MVCKGCGTNC KCQDTKCGDN CACNQDCKCV CKNGPKDQCC KSK