ID   MT4A_ORYSJ              Reviewed;          78 AA.
AC   Q0IMG5; Q2QNC6;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Metallothionein-like protein 4A;
DE   AltName: Full=Class I metallothionein-like protein 4A;
DE   AltName: Full=OsMT-I-4a;
DE   AltName: Full=OsMT1b;
GN   Name=MT4A; OrderedLocusNames=Os12g0570700, LOC_Os12g38270;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16188032; DOI=10.1186/1741-7007-3-20;
RG   The rice chromosomes 11 and 12 sequencing consortia;
RT   "The sequence of rice chromosomes 11 and 12, rich in disease resistance
RT   genes and recent gene duplications.";
RL   BMC Biol. 3:20-20(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
RN   [6]
RP   INDUCTION.
RX   PubMed=15781441; DOI=10.1093/jxb/eri131;
RA   Kobayashi T., Suzuki M., Inoue H., Itai R.N., Takahashi M., Nakanishi H.,
RA   Mori S., Nishizawa N.K.;
RT   "Expression of iron-acquisition-related genes in iron-deficient rice is co-
RT   ordinately induced by partially conserved iron-deficiency-responsive
RT   elements.";
RL   J. Exp. Bot. 56:1305-1316(2005).
RN   [7]
RP   GENE FAMILY, AND TISSUE SPECIFICITY.
RX   PubMed=17002881; DOI=10.5483/bmbrep.2006.39.5.595;
RA   Zhou G., Xu Y., Li J., Yang L., Liu J.-Y.;
RT   "Molecular analyses of the metallothionein gene family in rice (Oryza
RT   sativa L.).";
RL   J. Biochem. Mol. Biol. 39:595-606(2006).
CC   -!- FUNCTION: Metallothioneins have a high content of cysteine residues
CC       that bind various heavy metals. {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in roots. {ECO:0000269|PubMed:17002881}.
CC   -!- INDUCTION: By iron deficiency in roots. {ECO:0000269|PubMed:15781441}.
CC   -!- SIMILARITY: Belongs to the metallothionein superfamily. Type 15 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABA99658.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DP000011; ABA99658.2; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP008218; BAF30100.1; -; Genomic_DNA.
DR   EMBL; AP014968; BAT17737.1; -; Genomic_DNA.
DR   EMBL; AK103445; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; XP_015618461.1; XM_015762975.1.
DR   AlphaFoldDB; Q0IMG5; -.
DR   STRING; 4530.OS12T0570700-01; -.
DR   PaxDb; Q0IMG5; -.
DR   PRIDE; Q0IMG5; -.
DR   EnsemblPlants; Os12t0570700-01; Os12t0570700-01; Os12g0570700.
DR   GeneID; 4352580; -.
DR   Gramene; Os12t0570700-01; Os12t0570700-01; Os12g0570700.
DR   KEGG; osa:4352580; -.
DR   eggNOG; ENOG502SXDI; Eukaryota.
DR   HOGENOM; CLU_161105_1_0_1; -.
DR   InParanoid; Q0IMG5; -.
DR   OMA; NCSCNKY; -.
DR   OrthoDB; 1627904at2759; -.
DR   Proteomes; UP000000763; Chromosome 12.
DR   Proteomes; UP000059680; Chromosome 12.
DR   ExpressionAtlas; Q0IMG5; baseline and differential.
DR   Genevisible; Q0IMG5; OS.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR000347; Metalthion_15p.
DR   PANTHER; PTHR33543; PTHR33543; 1.
DR   Pfam; PF01439; Metallothio_2; 1.
PE   2: Evidence at transcript level;
KW   Metal-binding; Metal-thiolate cluster; Reference proteome.
FT   CHAIN           1..78
FT                   /note="Metallothionein-like protein 4A"
FT                   /id="PRO_0000263059"
SQ   SEQUENCE   78 AA;  7644 MW;  4973599B9EBD717F CRC64;
     MSCCGGSCNC GSSCKCGSGC GNMYPDLAEK TTNTSATMVL GVAPAKEQFE GVGKAAESGE
     AAHGCSCGSS CKCNPCNC