ID   MTAL1_CANAL             Reviewed;         193 AA.
AC   Q9UW19; Q59YW6;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Mating-type-like protein ALPHA1;
DE            Short=MTLalpha1 protein;
GN   Name=MTLALPHA1;
GN   OrderedLocusNames=C5_01755C_B {ECO:0000312|CGD:CAL0000202030};
GN   ORFNames=CaO19.10712;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=10455055; DOI=10.1126/science.285.5431.1271;
RA   Hull C.M., Johnson A.D.;
RT   "Identification of a mating type-like locus in the asexual pathogenic yeast
RT   Candida albicans.";
RL   Science 285:1271-1275(1999).
RN   [2]
RP   FUNCTION.
RX   PubMed=12176317; DOI=10.1016/s0092-8674(02)00837-1;
RA   Miller M.G., Johnson A.D.;
RT   "White-opaque switching in Candida albicans is controlled by mating-type
RT   locus homeodomain proteins and allows efficient mating.";
RL   Cell 110:293-302(2002).
RN   [3]
RP   FUNCTION.
RX   PubMed=14622594; DOI=10.1016/s0092-8674(03)00885-7;
RA   Tsong A.E., Miller M.G., Raisner R.M., Johnson A.D.;
RT   "Evolution of a combinatorial transcriptional circuit: a case study in
RT   yeasts.";
RL   Cell 115:389-399(2003).
RN   [4]
RP   INDUCTION.
RX   PubMed=15189997; DOI=10.1128/ec.3.3.764-775.2004;
RA   Pendrak M.L., Yan S.S., Roberts D.D.;
RT   "Hemoglobin regulates expression of an activator of mating-type locus alpha
RT   genes in Candida albicans.";
RL   Eukaryot. Cell 3:764-775(2004).
CC   -!- FUNCTION: Mating type proteins are sequence specific DNA-binding
CC       proteins that act as master switches in yeast differentiation by
CC       controlling gene expression in a cell type-specific fashion.
CC       Transcriptional activator that induces the transcription of alpha-
CC       specific mating genes. {ECO:0000269|PubMed:12176317,
CC       ECO:0000269|PubMed:14622594}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00655}.
CC   -!- INDUCTION: Induced by HBR1 in response to hemoglobin and growth
CC       signals. {ECO:0000269|PubMed:15189997}.
CC   -!- MISCELLANEOUS: The C.albicans mating-type-like (MTL) locus contains, in
CC       addition to the genes for the regulatory proteins (MTLA1, MTLA2,
CC       MTLALPHA1 and MTLALPHA2), a and alpha idiomorphs of a
CC       phosphatidylinositol kinase (PIKA and PIKALPHA), a poly(A) polymerase
CC       (PAPA and PAPALPHA) and an oxysterol binding protein-like protein (OBPA
CC       and OBPALPHA). MTLALPHA1 is not represented in the genomic sequence of
CC       strain SC5314 because that haploid assembly includes the mating type a
CC       allele of this locus. {ECO:0000305}.
CC   -!- MISCELLANEOUS: Most C.albicans strains are heterozygous at the MTL
CC       locus and do not readily undergo white-opaque switching and mating, but
CC       mating occurs in hemi- or homozygous strains. Mating takes place in
CC       opaque cells, produces tetraploid progeny and seems to occur rarely, if
CC       at all, in nature. Conservation of mating capacity is rather thought to
CC       be due to the simultaneously regulated white-opaque switch, which seems
CC       to play an important role in host commensalism.
CC   -!- SIMILARITY: Belongs to the MATALPHA1 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00655}.
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DR   EMBL; AF167163; AAD51411.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9UW19; -.
DR   CGD; CAL0000202030; MTLALPHA1.
DR   eggNOG; ENOG502T26R; Eukaryota.
DR   HOGENOM; CLU_1408558_0_0_1; -.
DR   InParanoid; Q9UW19; -.
DR   OMA; EPNKAIW; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008301; F:DNA binding, bending; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:CGD.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0045895; P:positive regulation of mating-type specific transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR016325; ALPHA1_Saccharomycetales.
DR   InterPro; IPR006856; MATalpha_HMGbox.
DR   Pfam; PF04769; MATalpha_HMGbox; 1.
DR   PIRSF; PIRSF001863; Transcrpt_activ_MAT_Alpha1; 1.
DR   PROSITE; PS51325; ALPHA_BOX; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Transcription; Transcription regulation.
FT   CHAIN           1..193
FT                   /note="Mating-type-like protein ALPHA1"
FT                   /id="PRO_0000206007"
FT   DNA_BIND        86..142
FT                   /note="Alpha box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00655"
SQ   SEQUENCE   193 AA;  22456 MW;  980E7E2EA8C7A2AB CRC64;
     MGNKKKTRKT VPKEFISLFR VHSGRDAPRR DTREVQKSKK HGFRFTSLPD LPVASNALQE
     LLLEYGLLND IKWDSKGLKA SKNKKTKLKP INSFIAFRSF YSRTISNPEH QRELSSKLAD
     VWTQESNQEV WKQYTQSYNN YLLLPDAKLN FVDWLCEALD YTIDNTTPQI EDISLTSYNQ
     LLSGTIEDVY IMK