MTAL1_CANGA
ID MTAL1_CANGA Reviewed; 191 AA.
AC Q874P0; Q6FX74; Q6FXB5; Q86Z70; Q870I5;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Mating-type-like protein ALPHA1;
GN Name=MTL1ALPHA1; Synonyms=ALPHA1; OrderedLocusNames=CAGL0B01243g;
GN and
GN Name=MTL3ALPHA1; OrderedLocusNames=CAGL0B00242g;
OS Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS Y-65) (Yeast) (Torulopsis glabrata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC Nakaseomyces/Candida clade.
OX NCBI_TaxID=284593;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX PubMed=12620120; DOI=10.1186/gb-2003-4-2-r10;
RA Wong S., Fares M.A., Zimmermann W., Butler G., Wolfe K.H.;
RT "Evidence from comparative genomics for a complete sexual cycle in the
RT 'asexual' pathogenic yeast Candida glabrata.";
RL Genome Biol. 4:R10.1-R10.9(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT SER-152.
RC STRAIN=1480.47, 7549, and PB921;
RX PubMed=12684382; DOI=10.1128/ec.2.2.328-340.2003;
RA Srikantha T., Lachke S.A., Soll D.R.;
RT "Three mating type-like loci in Candida glabrata.";
RL Eukaryot. Cell 2:328-340(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
RN [4]
RP DEVELOPMENTAL STAGE.
RX PubMed=14638801; DOI=10.1128/iai.71.12.7109-7118.2003;
RA Brockert P.J., Lachke S.A., Srikantha T., Pujol C., Galask R., Soll D.R.;
RT "Phenotypic switching and mating type switching of Candida glabrata at
RT sites of colonization.";
RL Infect. Immun. 71:7109-7118(2003).
CC -!- FUNCTION: Mating type proteins are sequence specific DNA-binding
CC proteins that act as master switches in yeast differentiation by
CC controlling gene expression in a cell type-specific fashion.
CC Transcriptional activator that induces the transcription of alpha-
CC specific genes (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00655}.
CC -!- DEVELOPMENTAL STAGE: Only present in alpha-cells (classes II and III).
CC {ECO:0000269|PubMed:14638801}.
CC -!- MISCELLANEOUS: There are three genetic loci for mating type genes in
CC C.glabrata. MTL1 seems to be the expression locus that determines the
CC mating type of the cell, whereas MTL2 (containing MTL2A1) and MTL3
CC (containing MTL3ALPHA1 and MTL3ALPHA2) appear to represent silenced
CC repositories of mating type information.
CC -!- MISCELLANEOUS: Haploid C.glabrata strains can switch mating type,
CC however, neither mating nor diploid forms of C.glabrata have been
CC observed so far.
CC -!- SIMILARITY: Belongs to the MATALPHA1 family. {ECO:0000255|PROSITE-
CC ProRule:PRU00655}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-8 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAP06781.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAP06783.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAP06785.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAG57879.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAG57924.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY181247; AAO25591.1; -; Genomic_DNA.
DR EMBL; AY191463; AAP06781.1; ALT_INIT; Genomic_DNA.
DR EMBL; AY191464; AAP06783.1; ALT_INIT; Genomic_DNA.
DR EMBL; AY207368; AAP06785.1; ALT_INIT; Genomic_DNA.
DR EMBL; CR380948; CAG57879.2; ALT_INIT; Genomic_DNA.
DR EMBL; CR380948; CAG57924.2; ALT_INIT; Genomic_DNA.
DR RefSeq; XP_444980.2; XM_444980.2.
DR RefSeq; XP_445024.2; XM_445024.2.
DR AlphaFoldDB; Q874P0; -.
DR STRING; 5478.XP_444980.2; -.
DR EnsemblFungi; CAG57879; CAG57879; CAGL0B00242g.
DR EnsemblFungi; CAG57924; CAG57924; CAGL0B01243g.
DR GeneID; 2886617; -.
DR GeneID; 2886684; -.
DR KEGG; cgr:CAGL0B00242g; -.
DR KEGG; cgr:CAGL0B01243g; -.
DR eggNOG; ENOG502S4ZK; Eukaryota.
DR HOGENOM; CLU_118234_1_0_1; -.
DR InParanoid; Q874P0; -.
DR Proteomes; UP000002428; Chromosome B.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008301; F:DNA binding, bending; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0045895; P:positive regulation of mating-type specific transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR016325; ALPHA1_Saccharomycetales.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR006856; MATalpha_HMGbox.
DR Pfam; PF04769; MATalpha_HMGbox; 1.
DR PIRSF; PIRSF001863; Transcrpt_activ_MAT_Alpha1; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS51325; ALPHA_BOX; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..191
FT /note="Mating-type-like protein ALPHA1"
FT /id="PRO_0000206008"
FT DNA_BIND 118..174
FT /note="Alpha box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00655"
FT VARIANT 152
FT /note="A -> S (in strain: 7549)"
FT /evidence="ECO:0000269|PubMed:12684382"
SQ SEQUENCE 191 AA; 21894 MW; DD2C4436484BC495 CRC64;
MLTETLTMKY TATKFRVRTN KRLRSQKYPE KHSDFLGCSS TKSSFGLNML LTKPNKFQIP
PPHPVLLKRI REERMKLTSS FESGINIIDI ETSWEIDKFI SHHFNTSIGN VLKSKSSSKK
RPMNAFMAFR TYYAQLGTGL KQNTLSVILS EAWNAPETDQ NIWDIFAQQF NFASPRCGFV
NYIMAHASSA P
