ID   MTAL1_KLUDE             Reviewed;         194 AA.
AC   Q874N0;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=Mating-type protein ALPHA1;
GN   Name=MATALPHA1; Synonyms=ALPHA1;
OS   Kluyveromyces delphensis (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces.
OX   NCBI_TaxID=51657;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CBS 2170;
RX   PubMed=12620120; DOI=10.1186/gb-2003-4-2-r10;
RA   Wong S., Fares M.A., Zimmermann W., Butler G., Wolfe K.H.;
RT   "Evidence from comparative genomics for a complete sexual cycle in the
RT   'asexual' pathogenic yeast Candida glabrata.";
RL   Genome Biol. 4:R10.1-R10.9(2003).
CC   -!- FUNCTION: Mating type proteins are sequence specific DNA-binding
CC       proteins that act as master switches in yeast differentiation by
CC       controlling gene expression in a cell type-specific fashion.
CC       Transcriptional activator that induces the transcription of alpha-
CC       specific genes (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00655}.
CC   -!- MISCELLANEOUS: There are three genetic loci for mating type genes in
CC       K.delphensis. MAT is the expression locus that determines the mating
CC       type of the cell, whereas HML (containing HMLALPHA1 and HMLALPHA2) and
CC       HMR (containing HMRA1) represent silenced repositories of mating type
CC       information. The mating type is determined by the MAT locus, which
CC       contains either a copy of HML or of HMR. Diploid cells are usually
CC       heterozygous for the MAT locus.
CC   -!- SIMILARITY: Belongs to the MATALPHA1 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00655}.
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DR   EMBL; AY181248; AAO25603.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q874N0; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008301; F:DNA binding, bending; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0045895; P:positive regulation of mating-type specific transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR016325; ALPHA1_Saccharomycetales.
DR   InterPro; IPR006856; MATalpha_HMGbox.
DR   Pfam; PF04769; MATalpha_HMGbox; 1.
DR   PIRSF; PIRSF001863; Transcrpt_activ_MAT_Alpha1; 1.
DR   PROSITE; PS51325; ALPHA_BOX; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Nucleus; Transcription; Transcription regulation.
FT   CHAIN           1..194
FT                   /note="Mating-type protein ALPHA1"
FT                   /id="PRO_0000206016"
FT   DNA_BIND        121..177
FT                   /note="Alpha box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00655"
SQ   SEQUENCE   194 AA;  22039 MW;  8A2F3454C72E6152 CRC64;
     MSVKTKKFVN KKYTTAKFKV TPTGKCRNKN NESIKKLIFN NGTKINTGLN LLLTQPNQVN
     IPPPPKILLD RIREERKRMV SSANSDITVI DIELCWEIDK FLAHHFQNTD SSKNDNYTKS
     NIKKPINAFI AFRAYYSQLG AGIKQNILSS ILSEAWNSPE TDQNIWDIFA QQFNFASARC
     GFVNYIMAQA SSAP