ID   MTAL1_PICAN             Reviewed;         195 AA.
AC   Q707Y7;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Mating-type protein ALPHA1;
DE   AltName: Full=MATalpha1 transcription factor;
GN   Name=MATALPHA1;
OS   Pichia angusta (Yeast) (Hansenula polymorpha).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Pichiaceae; Ogataea.
OX   NCBI_TaxID=870730;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 34438 / CBS 4732 / DSM 70277 / JCM 3621 / NBRC 1476 / NRRL
RC   Y-5445;
RX   PubMed=14745027; DOI=10.1073/pnas.0304170101;
RA   Butler G., Kenny C., Fagan A., Kurischko C., Gaillardin C., Wolfe K.H.;
RT   "Evolution of the MAT locus and its Ho endonuclease in yeast species.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:1632-1637(2004).
CC   -!- FUNCTION: Mating type proteins are sequence specific DNA-binding
CC       proteins that act as master switches in yeast differentiation by
CC       controlling gene expression in a cell type-specific fashion.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00655}.
CC   -!- MISCELLANEOUS: In P.angusta, all mating-type proteins (MATA1, MATALPHA1
CC       and MATALPHA2) are encoded on one idiomorph, consistent with the fact
CC       that P.angusta is a homothallic haploid in which any strain can mate
CC       with any other strain.
CC   -!- SIMILARITY: Belongs to the MATALPHA1 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00655}.
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DR   EMBL; AJ617305; CAE84418.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q707Y7; -.
DR   SMR; Q707Y7; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008301; F:DNA binding, bending; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0045895; P:positive regulation of mating-type specific transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR016325; ALPHA1_Saccharomycetales.
DR   InterPro; IPR006856; MATalpha_HMGbox.
DR   Pfam; PF04769; MATalpha_HMGbox; 1.
DR   PIRSF; PIRSF001863; Transcrpt_activ_MAT_Alpha1; 1.
DR   PROSITE; PS51325; ALPHA_BOX; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Nucleus; Transcription; Transcription regulation.
FT   CHAIN           1..195
FT                   /note="Mating-type protein ALPHA1"
FT                   /id="PRO_0000206020"
FT   DNA_BIND        89..145
FT                   /note="Alpha box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00655"
SQ   SEQUENCE   195 AA;  22756 MW;  1E0A70C19E76A9BB CRC64;
     MMFHVLCFFG NRTSRVANLC LQLKFPPHND SPKMALDELN LSFLTHLPQI PTTSPLLKRL
     LTEYGAIDNG KDSLNKVAPK KSSRHRVQKE KKRLNGFMAF RSFYSRNIAN YNSQKALSQD
     LADAWNREKH QQIWSLYAIQ YNHSKSKEPF SRWLEMKLSN KLGKFNSDDP TTRREINVMS
     HIVVEDVFQE CSSQY