ID   MTAL2_KLUDE             Reviewed;         174 AA.
AC   Q874N1;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Mating-type protein ALPHA2;
GN   Name=MATALPHA2; Synonyms=ALPHA2;
OS   Kluyveromyces delphensis (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces.
OX   NCBI_TaxID=51657;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CBS 2170;
RX   PubMed=12620120; DOI=10.1186/gb-2003-4-2-r10;
RA   Wong S., Fares M.A., Zimmermann W., Butler G., Wolfe K.H.;
RT   "Evidence from comparative genomics for a complete sexual cycle in the
RT   'asexual' pathogenic yeast Candida glabrata.";
RL   Genome Biol. 4:R10.1-R10.9(2003).
CC   -!- FUNCTION: Mating type proteins are sequence specific DNA-binding
CC       proteins that act as master switches in yeast differentiation by
CC       controlling gene expression in a cell type-specific fashion.
CC       Transcriptional corepressor that acts in conjunction with A1 to repress
CC       transcription of haploid-specific genes and of MATALPHA1 (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms a heterodimer with A1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- MISCELLANEOUS: There are three genetic loci for mating type genes in
CC       K.delphensis. MAT is the expression locus that determines the mating
CC       type of the cell, whereas HML (containing HMLALPHA1 and HMLALPHA2) and
CC       HMR (containing HMRA1) represent silenced repositories of mating type
CC       information. The mating type is determined by the MAT locus, which
CC       contains either a copy of HML or of HMR. Diploid cells are usually
CC       heterozygous for the MAT locus.
CC   -!- SIMILARITY: Belongs to the TALE/M-ATYP homeobox family. {ECO:0000305}.
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DR   EMBL; AY181248; AAO25604.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q874N1; -.
DR   SMR; Q874N1; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Homeobox; Nucleus; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..174
FT                   /note="Mating-type protein ALPHA2"
FT                   /id="PRO_0000049178"
FT   DNA_BIND        108..170
FT                   /note="Homeobox; TALE-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
SQ   SEQUENCE   174 AA;  20370 MW;  8BE75BCFA725E8CD CRC64;
     MESKKIAITE LLNPSNQENL KEKLQEINKQ LISLCSSLPK RNWVPAPSSD ILRSLSRTKL
     DSQEIRLIKT TYRLSTLLSK LQEKDIVFNV VTKDHLLKNG TPYNPYPQPY RGHRFTKENV
     HTLEAWYSNH IDNPYLDPKS LQSLAQKTNL SKIQIKNWVS NRRRKQKHPP FLLI