ID   MTAL2_YARLI             Reviewed;         367 AA.
AC   Q707Y0; Q6CCQ6;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Mating-type protein ALPHA2;
DE   AltName: Full=MATB2 transcription factor;
GN   Name=MATB2; Synonyms=YlMATB2; OrderedLocusNames=YALI0C07458g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 20460 / W29 / CBS 7504 / IFP29;
RX   PubMed=14745027; DOI=10.1073/pnas.0304170101;
RA   Butler G., Kenny C., Fagan A., Kurischko C., Gaillardin C., Wolfe K.H.;
RT   "Evolution of the MAT locus and its Ho endonuclease in yeast species.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:1632-1637(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Mating type proteins are sequence specific DNA-binding
CC       proteins that act as master switches in yeast differentiation by
CC       controlling gene expression in a cell type-specific fashion.
CC       Transcriptional corepressor that acts in conjunction with A1 to repress
CC       transcription of haploid-specific genes (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms a heterodimer with A1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Only present in B-cells and in A/B diploid cells.
CC   -!- SIMILARITY: Belongs to the TALE/M-ATYP homeobox family. {ECO:0000305}.
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DR   EMBL; AJ617307; CAE84425.1; -; Genomic_DNA.
DR   EMBL; CR382129; CAG81859.1; -; Genomic_DNA.
DR   RefSeq; XP_501556.1; XM_501556.1.
DR   AlphaFoldDB; Q707Y0; -.
DR   SMR; Q707Y0; -.
DR   EnsemblFungi; CAG81859; CAG81859; YALI0_C07458g.
DR   GeneID; 2909500; -.
DR   KEGG; yli:YALI0C07458g; -.
DR   VEuPathDB; FungiDB:YALI0_C07458g; -.
DR   HOGENOM; CLU_754799_0_0_1; -.
DR   Proteomes; UP000001300; Chromosome C.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   SUPFAM; SSF46689; SSF46689; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..367
FT                   /note="Mating-type protein ALPHA2"
FT                   /id="PRO_0000049184"
FT   DNA_BIND        273..338
FT                   /note="Homeobox; TALE-type"
SQ   SEQUENCE   367 AA;  42180 MW;  C53FBB535E1433D6 CRC64;
     MKETRDLLFY NENSIDFNFS PEEMDTHQMM CVNNDSQQDT SFLTATTCIF DFQKDIYDDQ
     NLMSFDPFFP QQRDMALWIA SVGNGAIDWS TKPQLTLSKK IPDVVNEKGE EITPADLQRH
     YADKHVAKLP DHSCDLYYLL FKHAKFEATT LRIPLSLLND NGTGALGPFD EIRSLTDEEQ
     RLLTLLKTIS HYSWVTKHAT KDCTGQLLDL CKEGLQLVES IQVNKTFNGV ILHILVAYFG
     RRSTALRDEF QLHKLFLEQR LDIELEILAQ HGGADAIDSE KLRKVKKLSE LWEWFNAIPY
     NHHPSVSQIE FIASQIGEKV SFVKSWVANK RRTGAKKRSK KPAPSTQIRP ALKVFLEKKP
     FVSRQVV