ID   MTAL3_KLULA             Reviewed;         897 AA.
AC   Q9HDS6; Q6CV27;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Mating-type protein ALPHA3;
DE            Short=Protein MAT-alpha-3;
DE   AltName: Full=Protein HML-alpha-3;
GN   Name=HMLALPHA3; Synonyms=alpha3; OrderedLocusNames=KLLA0C00396g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=10978277; DOI=10.1093/genetics/156.1.81;
RA   Aastroem S.U., Kegel A., Sjoestrand J.O.O., Rine J.;
RT   "Kluyveromyces lactis Sir2p regulates cation sensitivity and maintains a
RT   specialized chromatin structure at the cryptic alpha-locus.";
RL   Genetics 156:81-91(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Mating type proteins are sequence specific DNA-binding
CC       proteins that act as master switches in yeast differentiation by
CC       controlling gene expression in a cell type-specific fashion. Required
CC       for efficient mating as an alpha-cell. {ECO:0000269|PubMed:10978277}.
CC   -!- DEVELOPMENTAL STAGE: Only present in alpha-cells and in a/alpha diploid
CC       cells. {ECO:0000269|PubMed:10978277}.
CC   -!- MISCELLANEOUS: There are three genetic loci for mating type genes in
CC       K.lactis. MAT is the expression locus that determines the mating type
CC       of the cell, whereas HML (containing HMLALPHA1, HMLALPHA2 and
CC       HMLALPHA3) and HMR (containing HMRA1 and HMRA2) represent silenced
CC       repositories of mating type information. Notably, HMLALPHA3 is not
CC       silenced in K.lactis. The mating type is determined by the MAT locus,
CC       which contains either a copy of HML or of HMR. Diploid cells are
CC       usually heterozygous for the MAT locus.
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DR   EMBL; AF195066; AAG21090.1; -; Genomic_DNA.
DR   EMBL; CR382123; CAH01062.1; -; Genomic_DNA.
DR   RefSeq; XP_452212.1; XM_452212.1.
DR   AlphaFoldDB; Q9HDS6; -.
DR   PRIDE; Q9HDS6; -.
DR   EnsemblFungi; CAH01062; CAH01062; KLLA0_C00396g.
DR   GeneID; 2892032; -.
DR   KEGG; kla:KLLA0_C00396g; -.
DR   eggNOG; ENOG502T52Z; Eukaryota.
DR   HOGENOM; CLU_322637_0_0_1; -.
DR   InParanoid; Q9HDS6; -.
DR   OMA; HHINHER; -.
DR   Proteomes; UP000000598; Chromosome C.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..897
FT                   /note="Mating-type protein ALPHA3"
FT                   /id="PRO_0000096611"
SQ   SEQUENCE   897 AA;  105427 MW;  E89B6D2B0A3BC96D CRC64;
     MAQVDVTRWV IHPSGSYESE TRKRKLREEK RRKLNEIKRA SLVLNDSDFK NFEHWLVTSK
     GVGEYEQVFD FNFDAYTTRG KPAVDSSTSY SDNIFIDGDK NCKIDTKTIS FLDRKYQSNN
     QTKIESEKQM HVITLKNEQL IEECKNIRER LLELIREGTG YIFVRGWTGY RVNTIILKCH
     CKQDKCHQIL KPRCNVKKHH DPDNLKQFNC FSSFSVHFNV KLNTIKICFC HKSKHETLPI
     TIIPASLRQY ISTNLCFTAR ECFECLKRTP VYLEFTKSFD AKAIVRKIWK EISESQWNLD
     PDSKRSASKI LKRFQNTGDV ALLPVDNCSA DLNISLQKAK PIAFIYERII SEIQHDVTEI
     VIDSTFCLST DYKQYFVVVA SFFGKGVPVG FMATETNNVD HLTILWFLRS VLQKLPKVKC
     INSDWSLAEI KAINLLKCSN QICLFHTLTA IRCKRLASKK NMTESLFHQQ FQSLLNYEWV
     DDNIFDPTRY EEKYQEKVSE YQIREIVRLV RIAICDHILL HSAGLNKVFQ DSDSENVKVL
     KLYEYHLKQL YVITVQKFSL PCYFCYLFNQ YYNFTSFQIM SRVGKPTFFS VLRTSMMCES
     YFNQLKSWNL SGSRNYRFDT LIYILLNKEV AKIKESIRIT KKFEKEYDSN CLVQNHRKHL
     PTWRKQWIIE WKNILQELNC LQEKDVFNEC QQYGTNMTTW ICGCNDAKVS PSSTCIHLVS
     LYKQKFPFYH GYTLQRFGKR NNGVPLVQHE SLQSDTKIES TENMSFEISD VTINGVCNTT
     KQMSDANCRK LDYETEIDMI SENKHSEIDD ESEGKLRIFN FFLADEETRL LITQCPSFKS
     IIEEMTYIKQ RTQSEPQWKA KTNKPEKGFK YDSWIRCLKY YQCYADVKAN GNFPLPF