ID   MTA_STRPU               Reviewed;          64 AA.
AC   P04734;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 2.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Metallothionein-A;
DE            Short=MTA;
GN   Name=MTA;
OS   Strongylocentrotus purpuratus (Purple sea urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC   Strongylocentrotus.
OX   NCBI_TaxID=7668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2586524; DOI=10.1128/mcb.9.12.5445-5455.1989;
RA   Harlow P., Watkins E., Thornton R.D., Nemer M.;
RT   "Structure of an ectodermally expressed sea urchin metallothionein gene and
RT   characterization of its metal-responsive region.";
RL   Mol. Cell. Biol. 9:5445-5455(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3860837; DOI=10.1073/pnas.82.15.4992;
RA   Nemer M., Wilkinson D.G., Travaglini E.C., Sternberg E.J., Butt T.R.;
RT   "Sea urchin metallothionein sequence: key to an evolutionary diversity.";
RL   Proc. Natl. Acad. Sci. U.S.A. 82:4992-4994(1985).
RN   [3]
RP   STRUCTURE BY NMR.
RX   PubMed=10438629; DOI=10.1006/jmbi.1999.2967;
RA   Riek R., Precheur B., Wang Y., Mackay E.A., Wider G., Guntert P., Liu A.,
RA   Kaegi J.H.R., Wuethrich K.;
RT   "NMR structure of the sea urchin (Strongylocentrotus purpuratus)
RT   metallothionein MTA.";
RL   J. Mol. Biol. 291:417-428(1999).
CC   -!- FUNCTION: Metallothioneins have a high content of cysteine residues
CC       that bind various heavy metals.
CC   -!- INDUCTION: By heavy metals.
CC   -!- SIMILARITY: Belongs to the metallothionein superfamily. Type 4 family.
CC       {ECO:0000305}.
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DR   EMBL; M30606; AAA30067.1; -; Genomic_DNA.
DR   EMBL; K02464; AAA30061.1; -; mRNA.
DR   PIR; A25775; A25775.
DR   PIR; A33825; A33825.
DR   RefSeq; NP_999742.1; NM_214577.1.
DR   PDB; 1QJK; NMR; -; A=2-37.
DR   PDB; 1QJL; NMR; -; A=37-64.
DR   PDBsum; 1QJK; -.
DR   PDBsum; 1QJL; -.
DR   AlphaFoldDB; P04734; -.
DR   SMR; P04734; -.
DR   EnsemblMetazoa; XM_030990197; XP_030846057; LOC115926005.
DR   EnsemblMetazoa; XM_030990198; XP_030846058; LOC115926005.
DR   GeneID; 373380; -.
DR   KEGG; spu:373380; -.
DR   CTD; 373380; -.
DR   HOGENOM; CLU_2834403_0_0_1; -.
DR   EvolutionaryTrace; P04734; -.
DR   Proteomes; UP000007110; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR017980; Metalthion_4_echinoid/annelid.
DR   InterPro; IPR001396; Metalthion_4_echinoidea.
DR   InterPro; IPR017854; Metalthion_dom_sf.
DR   Pfam; PF05522; Metallothio_6; 1.
DR   PRINTS; PR00873; MTECHINOIDEA.
DR   SUPFAM; SSF57868; SSF57868; 2.
PE   1: Evidence at protein level;
KW   3D-structure; Metal-binding; Metal-thiolate cluster; Reference proteome.
FT   CHAIN           1..64
FT                   /note="Metallothionein-A"
FT                   /id="PRO_0000197347"
FT   CONFLICT        10
FT                   /note="K -> T (in Ref. 2; AAA30061)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        24
FT                   /note="K -> V (in Ref. 2; AAA30061)"
FT                   /evidence="ECO:0000305"
FT   HELIX           7..11
FT                   /evidence="ECO:0007829|PDB:1QJK"
FT   STRAND          19..21
FT                   /evidence="ECO:0007829|PDB:1QJK"
FT   HELIX           22..25
FT                   /evidence="ECO:0007829|PDB:1QJK"
FT   STRAND          29..32
FT                   /evidence="ECO:0007829|PDB:1QJK"
SQ   SEQUENCE   64 AA;  6445 MW;  66F0AA7A4991E3E6 CRC64;
     MPDVKCVCCK EGKECACFGQ DCCKTGECCK DGTCCGICTN AACKCANGCK CGSGCSCTEG
     NCAC