ID   MTB12_MYCBO             Reviewed;         168 AA.
AC   P0A5P9; A0A1R3Y111; O05822; X2BKH3;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Low molecular weight antigen MTB12;
DE   AltName: Full=CFP-2;
DE   AltName: Full=Low molecular weight protein antigen 2;
DE   Flags: Precursor;
GN   Name=mtb12; Synonyms=cfp2; OrderedLocusNames=BQ2027_MB2397C;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- FUNCTION: May play a role in the development of protective immune
CC       responses. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MTB12 family. {ECO:0000305}.
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DR   EMBL; LT708304; SIU01009.1; -; Genomic_DNA.
DR   RefSeq; NP_856046.1; NC_002945.3.
DR   RefSeq; WP_003412264.1; NC_002945.4.
DR   AlphaFoldDB; P0A5P9; -.
DR   EnsemblBacteria; SIU01009; SIU01009; BQ2027_MB2397C.
DR   PATRIC; fig|233413.5.peg.2634; -.
DR   OMA; FVNQGSW; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..48
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000021774"
FT   CHAIN           49..168
FT                   /note="Low molecular weight antigen MTB12"
FT                   /id="PRO_0000021775"
SQ   SEQUENCE   168 AA;  16635 MW;  A809937458009BFD CRC64;
     MKMVKSIAAG LTAAAAIGAA AAGVTSIMAG GPVVYQMQPV VFGAPLPLDP ASAPDVPTAA
     QLTSLLNSLA DPNVSFANKG SLVEGGIGGT EARIADHKLK KAAEHGDLPL SFSVTNIQPA
     AAGSATADVS VSGPKLSSPV TQNVTFVNQG GWMLSRASAM ELLQAAGN