MTB1_SOLLC
ID MTB1_SOLLC Reviewed; 613 AA.
AC A0A3Q7ELQ2;
DT 03-JUL-2019, integrated into UniProtKB/Swiss-Prot.
DT 10-APR-2019, sequence version 1.
DT 25-MAY-2022, entry version 15.
DE RecName: Full=Transcription factor MTB1 {ECO:0000303|PubMed:30610166};
DE AltName: Full=Basic helix-loop-helix protein 113 {ECO:0000303|PubMed:25612924};
DE AltName: Full=Protein MYC2-TARGETED BHLH 1 {ECO:0000303|PubMed:30610166};
DE AltName: Full=Transcription factor bHLH113 {ECO:0000303|PubMed:25612924};
DE AltName: Full=bHLH transcription factor bHLH113 {ECO:0000305};
GN Name=MTB1 {ECO:0000303|PubMed:30610166};
GN Synonyms=BHLH113 {ECO:0000303|PubMed:25612924};
GN OrderedLocusNames=Solyc01g096050 {ECO:0000305};
OS Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC Solanum subgen. Lycopersicon.
OX NCBI_TaxID=4081;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Heinz 1706;
RX PubMed=22660326; DOI=10.1038/nature11119;
RG Tomato Genome Consortium;
RT "The tomato genome sequence provides insights into fleshy fruit
RT evolution.";
RL Nature 485:635-641(2012).
RN [2]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=25612924; DOI=10.1186/s12864-014-1209-2;
RA Sun H., Fan H.J., Ling H.Q.;
RT "Genome-wide identification and characterization of the bHLH gene family in
RT tomato.";
RL BMC Genomics 16:9-9(2015).
RN [3]
RP FUNCTION, INTERACTION WITH MYC2 AND JAZ7, AND INDUCTION.
RX PubMed=30610166; DOI=10.1105/tpc.18.00405;
RA Liu Y., Du M., Deng L., Shen J., Fang M., Chen Q., Lu Y., Wang Q., Li C.,
RA Zhai Q.;
RT "MYC2 regulates the termination of jasmonate signaling via an
RT autoregulatory negative feedback loop.";
RL Plant Cell 31:106-127(2019).
CC -!- FUNCTION: Transcription factor that negatively regulates jasmonate (JA)
CC signaling (PubMed:30610166). Negatively regulates JA-dependent response
CC to wounding, JA-induced expression of defense genes, JA-dependent
CC responses against herbivorous insects, and JA-dependent resistance
CC against Botrytis cinerea infection (PubMed:30610166). Plays a positive
CC role in resistance against the bacterial pathogen Pseudomonas syringae
CC pv tomato DC3000 (PubMed:30610166). {ECO:0000269|PubMed:30610166}.
CC -!- SUBUNIT: Interacts with MYC2 (via N-terminus) (PubMed:30610166). MTB1
CC competes with MED25 for binding to MYC2 (PubMed:30610166). Interacts
CC (via N-terminus) with JAZ7 (PubMed:30610166).
CC {ECO:0000269|PubMed:30610166}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- INDUCTION: Induced by wounding, feeding with herbivorous insects,
CC infection with the fungal pathogen Botrytis cinerea and infection with
CC the bacterial pathogen Pseudomonas syringae pv tomato DC3000.
CC {ECO:0000269|PubMed:30610166}.
CC -!- CAUTION: Contains a degenerate basic motif not likely to bind DNA.
CC {ECO:0000255|PROSITE-ProRule:PRU00981}.
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DR EMBL; CM001064; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A3Q7ELQ2; -.
DR SMR; A0A3Q7ELQ2; -.
DR STRING; 4081.Solyc01g096050.2.1; -.
DR EnsemblPlants; Solyc01g096050.3.1; Solyc01g096050.3.1; Solyc01g096050.3.
DR Gramene; Solyc01g096050.3.1; Solyc01g096050.3.1; Solyc01g096050.3.
DR OMA; RFMFSNP; -.
DR Proteomes; UP000004994; Chromosome 1.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0031347; P:regulation of defense response; IMP:UniProtKB.
DR GO; GO:2000022; P:regulation of jasmonic acid mediated signaling pathway; IMP:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:UniProtKB.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR045084; AIB/MYC-like.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR025610; MYC/MYB_N.
DR PANTHER; PTHR11514; PTHR11514; 1.
DR Pfam; PF14215; bHLH-MYC_N; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Jasmonic acid signaling pathway; Nucleus; Plant defense;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..613
FT /note="Transcription factor MTB1"
FT /id="PRO_0000447548"
FT DOMAIN 430..479
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 48..130
FT /note="JAZ-interaction domain"
FT /evidence="ECO:0000305|PubMed:30610166"
FT REGION 256..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 391..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 430..443
FT /note="Basic motif; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 444..479
FT /note="Helix-loop-helix motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 490..513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..441
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 497..513
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 613 AA; 68254 MW; DE59DC7D447EA83C CRC64;
MVTGNMLWSG EDKAMVASVL GKEAFEYLMS GSVSAECSLM AIGNDQNLQN KLSDLVERPN
AANFSWNYAI FWQISRSKSG ELVLGWGDGC CREPKEAEER EVKKILNLRL DDEGQQRMRK
RVLQKLHMLF GGTDEDNYAF GLDRVTDTEM FFLASMYFSF PRGEGGPGKC FGSGKYLWLS
DALTSNLDYC ARSFLAKSAG MQTIALIPTD VGVVELGSVR SIPESLELLQ NIKSCFSSFL
SLVRDKQAAG IAAVPEKNEG NNPRLSNSGA VTERTDGNPK IFGHDLNSGT HFREKLAVRK
AEERPWDMYQ NGNRMPFVNA RNGLNPASWA QFSNVKLGKP VELYAPPTPG HNLMNGGREE
FRLNNFQHQK PAARMQIDFT GATSRTIVSP AHNVESEHSD VEASCKEDRA GPVDEKRPRK
RGRKPANGRE EPLNHVEAER QRREKLNQRF YALRAVVPNI SKMDKASLLG DAIAYITELQ
KKLRDMESER ELRLGSTSRD AITSEDSPSS EIQIRGPDIN IEAANDEVIV RVSCSLETHP
LSRIIQIFKE AQINVVESKL SAGNGTVYHT FVIKSSGSEQ LTKEKLLAAF SSESNSLRQL
SPKLHKVILP SLF
