MTB2_SOLLC
ID MTB2_SOLLC Reviewed; 579 AA.
AC A0A3Q7HES4;
DT 03-JUL-2019, integrated into UniProtKB/Swiss-Prot.
DT 10-APR-2019, sequence version 1.
DT 25-MAY-2022, entry version 16.
DE RecName: Full=Transcription factor MTB2 {ECO:0000303|PubMed:30610166};
DE AltName: Full=Basic helix-loop-helix protein 133 {ECO:0000303|PubMed:25612924};
DE AltName: Full=Protein MYC2-TARGETED BHLH 2 {ECO:0000303|PubMed:30610166};
DE AltName: Full=Transcription factor bHLH133 {ECO:0000303|PubMed:25612924};
DE AltName: Full=bHLH transcription factor bHLH133 {ECO:0000305};
GN Name=MTB2 {ECO:0000303|PubMed:30610166};
GN Synonyms=BHLH133 {ECO:0000303|PubMed:25612924};
GN OrderedLocusNames=Solyc05g050560 {ECO:0000305};
OS Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC Solanum subgen. Lycopersicon.
OX NCBI_TaxID=4081;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Heinz 1706;
RX PubMed=22660326; DOI=10.1038/nature11119;
RG Tomato Genome Consortium;
RT "The tomato genome sequence provides insights into fleshy fruit
RT evolution.";
RL Nature 485:635-641(2012).
RN [2]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=25612924; DOI=10.1186/s12864-014-1209-2;
RA Sun H., Fan H.J., Ling H.Q.;
RT "Genome-wide identification and characterization of the bHLH gene family in
RT tomato.";
RL BMC Genomics 16:9-9(2015).
RN [3]
RP FUNCTION, AND INDUCTION.
RX PubMed=30610166; DOI=10.1105/tpc.18.00405;
RA Liu Y., Du M., Deng L., Shen J., Fang M., Chen Q., Lu Y., Wang Q., Li C.,
RA Zhai Q.;
RT "MYC2 regulates the termination of jasmonate signaling via an
RT autoregulatory negative feedback loop.";
RL Plant Cell 31:106-127(2019).
CC -!- FUNCTION: Transcription factor that negatively regulates jasmonate (JA)
CC signaling (PubMed:30610166). Negatively regulates JA-dependent response
CC to wounding, JA-induced expression of defense genes, JA-dependent
CC responses against herbivorous insects, and JA-dependent resistance
CC against Botrytis cinerea infection (PubMed:30610166). Plays a positive
CC role in resistance against the bacterial pathogen Pseudomonas syringae
CC pv tomato DC3000 (PubMed:30610166). {ECO:0000269|PubMed:30610166}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- INDUCTION: Induced by wounding, feeding with herbivorous insects,
CC infection with the fungal pathogen Botrytis cinerea and infection with
CC the bacterial pathogen Pseudomonas syringae pv tomato DC3000.
CC {ECO:0000269|PubMed:30610166}.
CC -!- CAUTION: Contains a degenerate basic motif not likely to bind DNA.
CC {ECO:0000255|PROSITE-ProRule:PRU00981}.
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DR EMBL; CM001068; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_010321507.1; XM_010323205.2.
DR AlphaFoldDB; A0A3Q7HES4; -.
DR SMR; A0A3Q7HES4; -.
DR STRING; 4081.Solyc05g050560.1.1; -.
DR EnsemblPlants; Solyc05g050560.1.1; Solyc05g050560.1.1.1; Solyc05g050560.1.
DR GeneID; 101247327; -.
DR Gramene; Solyc05g050560.1.1; Solyc05g050560.1.1.1; Solyc05g050560.1.
DR KEGG; sly:101247327; -.
DR OMA; KADERSW; -.
DR Proteomes; UP000004994; Chromosome 5.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0031347; P:regulation of defense response; IMP:UniProtKB.
DR GO; GO:2000022; P:regulation of jasmonic acid mediated signaling pathway; IMP:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:UniProtKB.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR045084; AIB/MYC-like.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR025610; MYC/MYB_N.
DR PANTHER; PTHR11514; PTHR11514; 1.
DR Pfam; PF14215; bHLH-MYC_N; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Jasmonic acid signaling pathway; Nucleus; Plant defense;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..579
FT /note="Transcription factor MTB2"
FT /id="PRO_0000447549"
FT DOMAIN 428..477
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 373..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 428..441
FT /note="Basic motif; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 442..477
FT /note="Helix-loop-helix motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT COMPBIAS 373..388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..439
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 579 AA; 64271 MW; D835D8147F5FF1AF CRC64;
MTMLWSDEDK TMVAAVLGTK AFDYLMSSLV SAECSLMAMG SDENLQNMLS DLVERPNASN
FSWNYAIFWQ ISRSKLGELV LGWGDGCCRE AREGEESELT RILNIRLADE AQQRMRKRVL
QKLHMFFGGT DEDNYVSGLD KVTDTEMFFL ASMYFSFPRG QGGPGKCFTA GKHVWLSDVM
RSSVDYCSRS FLMKSAGMQT VVLIPTDIGV MELGSVRTIP ESLELVHSIK SCFSSFLAQV
RAKQAAPLAA VVAEKKNGNN SVFPSSFPFD QSKENPKIFG QNLESGSTEF REKLALRKPV
DGPLEMYRNG NRAPIINTQN GVRPVSWASF GNVKPGNSVD LYSPQAPPNN LREFVNGGRE
ELRLNSLQHQ KPGGMQIDFT NSRPVVSPVP TVESEHSDVE VSCKEKHAGP ADERRPRKRG
RKPANGREEP LNHVEAERQR REKLNQRFYA LRAVVPNISK MDKASLLGDA IAHITDMQKR
IRDAEYKLEK RGSTSVDAAD INIEAASDEV IVRARCPLGT HPVAKVVEAF KETQVSVVES
KLAVGNDTVY HTFVVKSSGP EQLTKEKLMA AFAGESNSL
