MTB3_SOLLC
ID MTB3_SOLLC Reviewed; 517 AA.
AC A0A3Q7H216;
DT 03-JUL-2019, integrated into UniProtKB/Swiss-Prot.
DT 10-APR-2019, sequence version 1.
DT 25-MAY-2022, entry version 15.
DE RecName: Full=Transcription factor MTB3 {ECO:0000303|PubMed:30610166};
DE AltName: Full=Basic helix-loop-helix protein 138 {ECO:0000303|PubMed:25612924};
DE AltName: Full=Protein MYC2-TARGETED BHLH 3 {ECO:0000303|PubMed:30610166};
DE AltName: Full=Transcription factor bHLH138 {ECO:0000303|PubMed:25612924};
DE AltName: Full=bHLH transcription factor bHLH138 {ECO:0000305};
GN Name=MTB3 {ECO:0000303|PubMed:30610166};
GN Synonyms=BHLH138 {ECO:0000303|PubMed:25612924};
GN OrderedLocusNames=Solyc06g083980 {ECO:0000305};
OS Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC Solanum subgen. Lycopersicon.
OX NCBI_TaxID=4081;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND IDENTIFICATION.
RC STRAIN=cv. Heinz 1706;
RX PubMed=22660326; DOI=10.1038/nature11119;
RG Tomato Genome Consortium;
RT "The tomato genome sequence provides insights into fleshy fruit
RT evolution.";
RL Nature 485:635-641(2012).
RN [2]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=25612924; DOI=10.1186/s12864-014-1209-2;
RA Sun H., Fan H.J., Ling H.Q.;
RT "Genome-wide identification and characterization of the bHLH gene family in
RT tomato.";
RL BMC Genomics 16:9-9(2015).
RN [3]
RP FUNCTION, AND INDUCTION.
RX PubMed=30610166; DOI=10.1105/tpc.18.00405;
RA Liu Y., Du M., Deng L., Shen J., Fang M., Chen Q., Lu Y., Wang Q., Li C.,
RA Zhai Q.;
RT "MYC2 regulates the termination of jasmonate signaling via an
RT autoregulatory negative feedback loop.";
RL Plant Cell 31:106-127(2019).
CC -!- FUNCTION: Transcription factor that negatively regulates jasmonate (JA)
CC signaling (PubMed:30610166). Negatively regulates JA-dependent response
CC to wounding, JA-induced expression of defense genes, JA-dependent
CC responses against herbivorous insects, and JA-dependent resistance
CC against Botrytis cinerea infection (PubMed:30610166). Plays a positive
CC role in resistance against the bacterial pathogen Pseudomonas syringae
CC pv tomato DC3000 (PubMed:30610166). {ECO:0000269|PubMed:30610166}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- INDUCTION: Induced by wounding, feeding with herbivorous insects,
CC infection with the fungal pathogen Botrytis cinerea and infection with
CC the bacterial pathogen Pseudomonas syringae pv tomato DC3000.
CC {ECO:0000269|PubMed:30610166}.
CC -!- CAUTION: Contains a degenerate basic motif not likely to bind DNA.
CC {ECO:0000255|PROSITE-ProRule:PRU00981}.
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DR EMBL; CM001069; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A3Q7H216; -.
DR SMR; A0A3Q7H216; -.
DR STRING; 4081.Solyc06g083980.1.1; -.
DR EnsemblPlants; Solyc06g083980.2.1; Solyc06g083980.2.1; Solyc06g083980.2.
DR Gramene; Solyc06g083980.2.1; Solyc06g083980.2.1; Solyc06g083980.2.
DR OMA; ALCKIVE; -.
DR Proteomes; UP000004994; Chromosome 6.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0031347; P:regulation of defense response; IMP:UniProtKB.
DR GO; GO:2000022; P:regulation of jasmonic acid mediated signaling pathway; IMP:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:UniProtKB.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR045084; AIB/MYC-like.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR025610; MYC/MYB_N.
DR PANTHER; PTHR11514; PTHR11514; 2.
DR Pfam; PF14215; bHLH-MYC_N; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Jasmonic acid signaling pathway; Nucleus; Plant defense;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..517
FT /note="Transcription factor MTB3"
FT /id="PRO_0000447550"
FT DOMAIN 327..376
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 290..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 327..340
FT /note="Basic motif; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 341..376
FT /note="Helix-loop-helix motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT COMPBIAS 300..331
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 517 AA; 57732 MW; B54B475D205FB9A9 CRC64;
MAEKFFLKGE DKVNMEGVLG SEAVEFFSWS ASNHMLTEFT SSRGDLGVQQ ALCKIVEGSD
WTYAIYWQVA KSKSGKSALI WGDGHCRETK IGQGEGANDS AHQKMMDGNK KKMVLQKIHT
CFGGSEDDNI AAKLESVSDV EVFYLTSMYY IFPFDKPSSP SQSFNSARSI WGSDLKGCLE
HFQSRSYLAK LARFETLVFV PLKSGVVELG SVKSIPEDQN LIQMVKTSVV VSNPPQPKAN
TKIFGRELSL GGAKSGPISI NFSPKVEEEL SFASDSYEVQ AALGSSQVYG NSSNGYRSDE
GEGKLYKEEL DERKPRKRGR KPANGREEAL NHVEAERQRR EKLNQRFYAL RAVVPNISKM
DKASLLGDAI AYITDLQARI RVLDAEKEMV GDKQKQQVIL EIDFHQRQDD AVVRVGCPLN
AHPVSRVLKT FQEHQVVAQE SNVSLTENGE LVHMFSIRAP GPAAEDLKEK LTAASRFALK
TRWSVSVIRL LCFARLFVYE HQCLAGKFAL YFVDYTI
