MTBA_METMA
ID MTBA_METMA Reviewed; 339 AA.
AC P58984;
DT 02-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Methylcobamide:CoM methyltransferase MtbA;
DE EC=2.1.1.247;
DE AltName: Full=MT2-A;
DE AltName: Full=Methylcobamide:CoM methyltransferase II isozyme A;
DE AltName: Full=[Methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M;
GN Name=mtbA; OrderedLocusNames=MM_1439;
OS Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM
OS 11833 / OCM 88) (Methanosarcina frisia).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX NCBI_TaxID=192952;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88;
RX PubMed=12125824;
RA Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A.,
RA Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C.,
RA Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S.,
RA Bhattacharyya A., Lykidis A., Overbeek R., Klenk H.-P., Gunsalus R.P.,
RA Fritz H.-J., Gottschalk G.;
RT "The genome of Methanosarcina mazei: evidence for lateral gene transfer
RT between Bacteria and Archaea.";
RL J. Mol. Microbiol. Biotechnol. 4:453-461(2002).
CC -!- FUNCTION: Methyltransferase involved in methanogenesis from
CC methylamines methanol pathway. Catalyzes the transfer of the methyl
CC group from the methylated corrinoid protein MtmC (MtmC1 or MtmC2) to
CC coenzyme M, forming the substrate for coenzyme-B
CC sulfoethylthiotransferase.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=coenzyme M + methyl-Co(III)-[methylamine-specific corrinoid
CC protein] = Co(I)-[methylamine-specific corrinoid protein] + H(+) +
CC methyl-coenzyme M; Xref=Rhea:RHEA:18773, Rhea:RHEA-COMP:11120,
CC Rhea:RHEA-COMP:11121, ChEBI:CHEBI:15378, ChEBI:CHEBI:58286,
CC ChEBI:CHEBI:58319, ChEBI:CHEBI:85033, ChEBI:CHEBI:85035;
CC EC=2.1.1.247;
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC -!- PATHWAY: One-carbon metabolism; methanogenesis from methylated amine.
CC -!- SIMILARITY: Belongs to the uroporphyrinogen decarboxylase family.
CC MtbA/MtaA subfamily. {ECO:0000305}.
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DR EMBL; AE008384; AAM31135.1; -; Genomic_DNA.
DR RefSeq; WP_011033385.1; NC_003901.1.
DR AlphaFoldDB; P58984; -.
DR SMR; P58984; -.
DR STRING; 192952.MM_1439; -.
DR EnsemblBacteria; AAM31135; AAM31135; MM_1439.
DR GeneID; 24883273; -.
DR GeneID; 66137128; -.
DR KEGG; mma:MM_1439; -.
DR PATRIC; fig|192952.21.peg.1665; -.
DR eggNOG; arCOG03323; Archaea.
DR HOGENOM; CLU_040933_2_1_2; -.
DR OMA; GAYWPEA; -.
DR UniPathway; UPA00650; -.
DR Proteomes; UP000000595; Chromosome.
DR GO; GO:0043833; F:[methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004853; F:uroporphyrinogen decarboxylase activity; IEA:InterPro.
DR GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:InterPro.
DR GO; GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:InterPro.
DR CDD; cd03307; Mta_CmuA_like; 1.
DR Gene3D; 3.20.20.210; -; 1.
DR InterPro; IPR006360; Mtase_MtaA_CmuA.
DR InterPro; IPR038071; UROD/MetE-like_sf.
DR InterPro; IPR000257; Uroporphyrinogen_deCOase.
DR Pfam; PF01208; URO-D; 1.
DR SUPFAM; SSF51726; SSF51726; 1.
DR TIGRFAMs; TIGR01463; mtaA_cmuA; 1.
PE 3: Inferred from homology;
KW Metal-binding; Methanogenesis; Methyltransferase; Reference proteome;
KW Transferase; Zinc.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..339
FT /note="Methylcobamide:CoM methyltransferase MtbA"
FT /id="PRO_0000187669"
FT BINDING 239
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 241
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 316
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255"
SQ SEQUENCE 339 AA; 36713 MW; 4D84BB93F4773018 CRC64;
MTEYTPKERL YRALRKQPVD RMPAVCFTQT GTVEQMEASG AFWPEAHADA EKMAKLAEAG
HTVIGFEAVR VPFDITAEAE LFGCGIKAGD LKQQPSVIKH SVKNLEDLDK IKNYSLDTGR
IGTILKAVKI LSEKYGKELP VIGSMIGPFS LAQHINGDAW FGNLFTGEDI VPALLDFCAD
FNIAYAKAMV ENGADTIAII DPTASYELIG GEFYEKYALP YQKKIVDAMK ELDVATVLHI
CGNTTNGLAI MDRTGVNAIS VDQRVDIKTA TGNVENAIIV GNLDPVAVLW NGTPEDVEAA
SKKVLDAGVG ILTVGCGIVS MTPSANLQKM VECAKNYRY
