ID   MTBP_XENTR              Reviewed;         867 AA.
AC   Q0P4G8; A9JRI5;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Mdm2-binding protein;
GN   Name=mtbp;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6; TISSUE=Oviduct, and Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in mdm2-dependent p53/TP53 homeostasis in
CC       unstressed cells. Inhibits autoubiquitination of mdm2, thereby
CC       enhancing mdm2 stability. This promotes mdm2-mediated ubiquitination of
CC       p53/TP53 and its subsequent degradation (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MTBP family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI22087.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC122086; AAI22087.1; ALT_INIT; mRNA.
DR   EMBL; BC155673; AAI55674.1; -; mRNA.
DR   RefSeq; NP_001107690.1; NM_001114218.1.
DR   AlphaFoldDB; Q0P4G8; -.
DR   PaxDb; Q0P4G8; -.
DR   GeneID; 779505; -.
DR   KEGG; xtr:779505; -.
DR   CTD; 27085; -.
DR   Xenbase; XB-GENE-990920; mtbp.
DR   eggNOG; ENOG502RGBH; Eukaryota.
DR   InParanoid; Q0P4G8; -.
DR   OrthoDB; 1334548at2759; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000003129; Expressed in egg cell and 13 other tissues.
DR   GO; GO:0000776; C:kinetochore; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0034501; P:protein localization to kinetochore; IBA:GO_Central.
DR   GO; GO:0031396; P:regulation of protein ubiquitination; IEA:InterPro.
DR   GO; GO:0007089; P:traversing start control point of mitotic cell cycle; IBA:GO_Central.
DR   InterPro; IPR039061; MTBP.
DR   InterPro; IPR029418; MTBP_C.
DR   InterPro; IPR029420; MTBP_central.
DR   InterPro; IPR029421; MTBP_N.
DR   PANTHER; PTHR14382; PTHR14382; 1.
DR   Pfam; PF14920; MTBP_C; 1.
DR   Pfam; PF14919; MTBP_mid; 1.
DR   Pfam; PF14918; MTBP_N; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Growth arrest; Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..867
FT                   /note="Mdm2-binding protein"
FT                   /id="PRO_0000323748"
FT   REGION          679..699
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          724..793
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        724..739
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        748..779
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   867 AA;  97059 MW;  C0B9694A05530FD5 CRC64;
     MERFVLCIHW ERRAESGAEQ HRVPQGLAYA QDIYTQLKEY STKYTSTFPA CSLTGNPGTR
     KWFFALQSLY GSFQFCSSDW DDLCPAVTTE DNEEPVQTAL DECLEALQFP DGEDDNSRDS
     ISQTNLFEEA AELLHQLSDK LPAPGRALVD VLLFTPEAPK LKDCLSAIGA IKHLKEWHSA
     KITIVSKDCK GWQKIAKFLS ANVVESACPK ELIDSHELWR GNIEISERKF TSEVEFPEFC
     LRSVSDDKFP YFEHNGDDKN KAVLLPEVFH YYGTSLEYVQ MVALSEIPSY FVSDSVFELS
     ITRNALQGKS KLMLDQLCSL TDKVGAIFML SCNVCSLPNP PALQRSSKKW REYMSRKPKD
     IKVPGVELKG EYCSYYFLIQ GKGSGFCKAT LLHSASQISG AASLVLLHQR LNNYQPGNMA
     EGTSEILDSV PHFRGEQIAV RERILARAQA LAVNEYLKRH EALPHPSVSH VNNLRTLLAV
     TRERVIGDCE SRLDGVSYKN LQNITVSTPT VSESEAMISN PADWPERNVL QNLENFEKVK
     QRLRASILSS SAEQLLGRKD GLKEGMTLLD AKELLKYFTP QGIAVGELQP LQVQRGDNAF
     LLTPKLTPKK LKGLPFEKAA ECHYHGLEYC LDNRKALDRD VAFSELQSRL IRYETQTTCT
     RECCPVPFAL SPLPSPAVLS EPGSVPDGES IQTELRGEPL LLKRRSRDLD GLYASKRLAK
     SGSSDSLVSL ASEGSGHQPP TRATRLRPER AASSTSAVQP PSARVQMAPS VPAQSKQSTH
     PDLEQKESRS QKHNRMLKEV VSKTLQKYGI GVEHPCYAAC NQRLFDISKF FLKDLKTSRG
     LLDEMKKAAS NNAKQVIQWE LDKLKKK