ID   MTC1_SCHPO              Reviewed;         455 AA.
AC   O94548;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Maintenance of telomere capping protein 1;
GN   ORFNames=SPCC1322.09;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Involved in telomere capping. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the MTC1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CU329672; CAA22862.1; -; Genomic_DNA.
DR   PIR; T40940; T40940.
DR   RefSeq; NP_588137.1; NM_001023127.2.
DR   AlphaFoldDB; O94548; -.
DR   BioGRID; 275472; 1.
DR   STRING; 4896.SPCC1322.09.1; -.
DR   iPTMnet; O94548; -.
DR   MaxQB; O94548; -.
DR   PaxDb; O94548; -.
DR   PRIDE; O94548; -.
DR   EnsemblFungi; SPCC1322.09.1; SPCC1322.09.1:pep; SPCC1322.09.
DR   GeneID; 2538894; -.
DR   KEGG; spo:SPCC1322.09; -.
DR   PomBase; SPCC1322.09; -.
DR   VEuPathDB; FungiDB:SPCC1322.09; -.
DR   eggNOG; ENOG502QU4J; Eukaryota.
DR   HOGENOM; CLU_034224_0_1_1; -.
DR   InParanoid; O94548; -.
DR   OMA; WVAEWVE; -.
DR   PhylomeDB; O94548; -.
DR   PRO; PR:O94548; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0005794; C:Golgi apparatus; ISO:PomBase.
DR   InterPro; IPR018814; DUF5427.
DR   PANTHER; PTHR28265; PTHR28265; 1.
DR   Pfam; PF10310; DUF5427; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..455
FT                   /note="Maintenance of telomere capping protein 1"
FT                   /id="PRO_0000343155"
FT   REGION          1..113
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          296..317
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..74
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        77..113
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   455 AA;  50886 MW;  F32054A36F7E9533 CRC64;
     MAETKEQTDD VETLMASLDQ LGMEADPTSK EFNNDDSKIG APSEVQDEKE LLEFLDQLEN
     DEEKNEKNPI EEANEENESV AATSNERQQH DASNQPSQAA QTTINKNTES ATPKTVNEIN
     KSQEFQEHVE TPKQSNWLGG FWSTASAAVR SAEQRVRSIK GFEENANWDI NVRNMVDLNK
     LGDLSNGIRS KALPTLSNTI HNVLNVVAPP IHDHEVLQVT VFHDLAGFAH LDRIVYESFE
     KVMFQVEGGE LTVLLDKEAK VRPRTNDVYE DFGLCNGYLE AKKLAKANLA EPITEAKKMN
     KENKQENVGA GDDEDASESP MVRVTHLLLV IQAFTIKNKE VSDDEQLCFL IHLNDTNHNL
     EFSTTSQPLP LEWQRWAVDP RYIKLFGSNA ILPNEWVTEW VEQSISVAAG IVAQMYTSKR
     MALGDPSLFA GLPEEDVNTG SSETPVPYYD GAMYA