MTC2_YEAST
ID MTC2_YEAST Reviewed; 357 AA.
AC P34246; D6VXI9;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Maintenance of telomere capping protein 2;
GN Name=MTC2; OrderedLocusNames=YKL098W; ORFNames=YKL448;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8256524; DOI=10.1002/yea.320091016;
RA Pallier C., Valens M., Puzos V., Fukuhara H., Cheret G., Sor F.,
RA Bolotin-Fukuhara M.;
RT "DNA sequence analysis of a 17 kb fragment of yeast chromosome XI
RT physically localizes the MRB1 gene and reveals eight new open reading
RT frames, including a homologue of the KIN1/KIN2 and SNF1 protein kinases.";
RL Yeast 9:1149-1155(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8196765; DOI=10.1038/369371a0;
RA Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V.,
RA Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P.,
RA Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L.,
RA Daignan-Fornier B., del Rey F., Dion C., Domdey H., Duesterhoeft A.,
RA Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H.,
RA Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L.,
RA Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M.,
RA Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H.,
RA Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J.,
RA Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H.,
RA Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J.,
RA Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S.,
RA Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F.,
RA Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R.,
RA Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W.,
RA Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M.,
RA Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C.,
RA Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H.,
RA Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L.,
RA van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S.,
RA von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M.,
RA Becker I., Mewes H.-W.;
RT "Complete DNA sequence of yeast chromosome XI.";
RL Nature 369:371-378(1994).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP DISRUPTION PHENOTYPE.
RX PubMed=18056469; DOI=10.1158/0008-5472.can-07-2399;
RA Xia L., Jaafar L., Cashikar A., Flores-Rozas H.;
RT "Identification of genes required for protection from doxorubicin by a
RT genome-wide screen in Saccharomyces cerevisiae.";
RL Cancer Res. 67:11411-11418(2007).
RN [5]
RP FUNCTION.
RX PubMed=18845848; DOI=10.1534/genetics.108.092577;
RA Addinall S.G., Downey M., Yu M., Zubko M.K., Dewar J., Leake A.,
RA Hallinan J., Shaw O., James K., Wilkinson D.J., Wipat A., Durocher D.,
RA Lydall D.;
RT "A genomewide suppressor and enhancer analysis of cdc13-1 reveals varied
RT cellular processes influencing telomere capping in Saccharomyces
RT cerevisiae.";
RL Genetics 180:2251-2266(2008).
CC -!- FUNCTION: May be involved in telomere capping.
CC {ECO:0000269|PubMed:18845848}.
CC -!- DISRUPTION PHENOTYPE: Decreases resistance to doxorubicin.
CC {ECO:0000269|PubMed:18056469}.
CC -!- SIMILARITY: Belongs to the MTC2 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X71133; CAA50459.1; -; Genomic_DNA.
DR EMBL; Z28098; CAA81938.1; -; Genomic_DNA.
DR EMBL; BK006944; DAA09059.1; -; Genomic_DNA.
DR PIR; S37925; S37925.
DR RefSeq; NP_012824.1; NM_001179664.1.
DR AlphaFoldDB; P34246; -.
DR BioGRID; 34035; 178.
DR DIP; DIP-4865N; -.
DR IntAct; P34246; 2.
DR STRING; 4932.YKL098W; -.
DR iPTMnet; P34246; -.
DR MaxQB; P34246; -.
DR PaxDb; P34246; -.
DR PRIDE; P34246; -.
DR EnsemblFungi; YKL098W_mRNA; YKL098W; YKL098W.
DR GeneID; 853763; -.
DR KEGG; sce:YKL098W; -.
DR SGD; S000001581; MTC2.
DR VEuPathDB; FungiDB:YKL098W; -.
DR eggNOG; ENOG502QQMN; Eukaryota.
DR HOGENOM; CLU_060779_1_0_1; -.
DR InParanoid; P34246; -.
DR OMA; HKFWFAC; -.
DR BioCyc; YEAST:G3O-31888-MON; -.
DR PRO; PR:P34246; -.
DR Proteomes; UP000002311; Chromosome XI.
DR RNAct; P34246; protein.
PE 3: Inferred from homology;
KW Reference proteome.
FT CHAIN 1..357
FT /note="Maintenance of telomere capping protein 2"
FT /id="PRO_0000203161"
SQ SEQUENCE 357 AA; 39842 MW; 2A93FD1667A6F4A1 CRC64;
MGDHNLPDFQ TCLKFSVTAK KSFLCMYRDS VSKEKLASSM PSTCDIQLKR AINDAYPGGG
IKVTVLNSTT ASLDSLATTH VKEFEIVIIP DINSLLQPDQ AKLVKIMRDC TVAIEKAQST
RIFIGVVHWN NPVQPSGAAK DGDEAGKPAP KTRIFLPTSF RMGAWLKHKF WFACAPPYLD
FESSTESSIN TRANNSIGMA EEEKQEPESK RSIILNEEAN LNDVFVGSTV RRYILDIMVH
LRTHRLTYNA KAGGVYTNSL DDVVLLSRLI GLHSGKMFVS PSHVKEASRW YFPMHLELVQ
RSSMDSSLLY GSDPNLVDEM LEKLAKIKCE EVNEFENPLF LESLVVKNVL SKVVPPV
