ID   MTC6_KOMPG              Reviewed;         528 AA.
AC   C4QYK3;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Maintenance of telomere capping protein 6;
DE   Flags: Precursor;
GN   Name=MTC6; OrderedLocusNames=PAS_chr1-4_0474;
OS   Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Phaffomycetaceae; Komagataella.
OX   NCBI_TaxID=644223;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GS115 / ATCC 20864;
RX   PubMed=19465926; DOI=10.1038/nbt.1544;
RA   De Schutter K., Lin Y.-C., Tiels P., Van Hecke A., Glinka S.,
RA   Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT   "Genome sequence of the recombinant protein production host Pichia
RT   pastoris.";
RL   Nat. Biotechnol. 27:561-566(2009).
CC   -!- FUNCTION: May be involved in telomere capping. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the MTC6 family. {ECO:0000305}.
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DR   EMBL; FN392319; CAY68326.1; -; Genomic_DNA.
DR   RefSeq; XP_002490607.1; XM_002490562.1.
DR   AlphaFoldDB; C4QYK3; -.
DR   STRING; 644223.C4QYK3; -.
DR   EnsemblFungi; CAY68326; CAY68326; PAS_chr1-4_0474.
DR   GeneID; 8197062; -.
DR   KEGG; ppa:PAS_chr1-4_0474; -.
DR   eggNOG; ENOG502QVFP; Eukaryota.
DR   HOGENOM; CLU_033723_0_0_1; -.
DR   InParanoid; C4QYK3; -.
DR   OMA; NTITHYS; -.
DR   Proteomes; UP000000314; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..14
FT                   /evidence="ECO:0000255"
FT   CHAIN           15..528
FT                   /note="Maintenance of telomere capping protein 6"
FT                   /id="PRO_0000407782"
FT   TOPO_DOM        15..480
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        481..501
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        502..528
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        37
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        73
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        202
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        257
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        278
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        281
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        328
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        366
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        376
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        394
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        442
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   528 AA;  59673 MW;  A682D739D7D0623E CRC64;
     MIIAFFLLIQ CVYCVIWPPL SVDNEVALRS QRDVSYNVSV DQLVDVGVRL STVIFERDTY
     TQPYLNRVDN LLNASVGNIL IDAYWDEGGF NWQLCPAPFS ANVTPIADGS TILQLEWDNK
     QYTCDRRLDL ASIFTRIDEH IRASARSVSL NLITIYMSLH SIGTQNPTPV SQPGTLSRPL
     VRSIDQVQIL TPASLRVAQL SNSTYQGLEF DPNGYPILGE LLQSRGIRVI PIILENNMYE
     DTSYELERDS NLYFIQNSTI DVTQTNTADT KLTDLTTNIT NWTIADSQAL LSESFRLVME
     TEEDPFSLES YTNHISHGYS PFLNRKYNES EIRQFAVNRL WSWKNSYLPE VSVPLLGDQD
     DSNSANETLQ CASFSNLSWI ISSCDEPRQV ACRNSSYWLQ WTVTSTLSNY YGATEACPVG
     TFFDIPRTPL DSMTLQREIP LNSSVWIDLN TLDSGGCWIS GGAEAECPYH RVTLVSLYVE
     ILTPSSVVSI VLIAIVVLLH FVRIPIQKNR KYWRKLQDNI KDSDGIPS