ID   MTC6_PICGU              Reviewed;         568 AA.
AC   A5DGH6;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=Maintenance of telomere capping protein 6;
DE   Flags: Precursor;
GN   Name=MTC6; ORFNames=PGUG_02377;
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS   / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: May be involved in telomere capping. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the MTC6 family. {ECO:0000305}.
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DR   EMBL; CH408157; EDK38279.2; -; Genomic_DNA.
DR   RefSeq; XP_001484648.1; XM_001484598.1.
DR   AlphaFoldDB; A5DGH6; -.
DR   STRING; 4929.XP_001484648.1; -.
DR   EnsemblFungi; EDK38279; EDK38279; PGUG_02377.
DR   GeneID; 5126771; -.
DR   KEGG; pgu:PGUG_02377; -.
DR   VEuPathDB; FungiDB:PGUG_02377; -.
DR   eggNOG; ENOG502QVFP; Eukaryota.
DR   HOGENOM; CLU_033723_0_0_1; -.
DR   InParanoid; A5DGH6; -.
DR   OMA; NLNESWY; -.
DR   OrthoDB; 618092at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..568
FT                   /note="Maintenance of telomere capping protein 6"
FT                   /id="PRO_0000407781"
FT   TOPO_DOM        21..512
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        513..533
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        534..568
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        23
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        68
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        94
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        109
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        174
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        193
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        197
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        230
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        339
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        382
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   568 AA;  64643 MW;  DE46EF4C589A96B3 CRC64;
     MLLFLVCFVC NIWSVFGVQA ASNVSDVVNT IVVASRTQRD ISMLVPIGQT NNMGVSLNTV
     LFEKVGYNSS SLDYIRQLLD GGLQTWMLDL YYNNATSNWQ LCPAPFPQNS STNAYETRTV
     RWNNRDYHCQ PSFTLDSVMQ EFRSYFMSTN TNIAVNLIQI MFNLYDFDFS ESKNKTIASK
     ELKNYATFSN YGNSTLNSSL SSVSDMLYTP QDLTTYQKTQ SGTGISAFYN TSAFDFPSSQ
     TFLLNDYKRL ITYVAENKVP KSALGSNDEN TIFFNEDFAD ISYTSDESLL ERCGSRTLSD
     FNQLSLNSNF RTVVDNENVP FTPSSFRKYV TCGYSPILNA SRYSIPNKPA TTDISDILTY
     YFPRSYWSWA PGQPHDRQHT ANTSSFDKRD YKSSDNQMAR KCVTLQESGF VLSNCYEEHK
     FACQKFNSPN EWKISVSSDT YFSDDYGDCP EGYSFNVPQS SIEVDSLRQE VANSGEKYPI
     WVDLNDITVA NCFVTGGPYA QCPYQRTVSG RRLVELIAPS FVVASVIVVL IFIEKIFRVN
     PVQTNRKRYW RRAINEYNKQ HGYEGVPS