ID   MTC6_VANPO              Reviewed;         532 AA.
AC   A7TEV4;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Maintenance of telomere capping protein 6;
DE   Flags: Precursor;
GN   Name=MTC6; ORFNames=Kpol_1050p58;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: May be involved in telomere capping. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the MTC6 family. {ECO:0000305}.
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DR   EMBL; DS480381; EDO19200.1; -; Genomic_DNA.
DR   RefSeq; XP_001647058.1; XM_001647008.1.
DR   AlphaFoldDB; A7TEV4; -.
DR   STRING; 436907.A7TEV4; -.
DR   EnsemblFungi; EDO19200; EDO19200; Kpol_1050p58.
DR   GeneID; 5547533; -.
DR   KEGG; vpo:Kpol_1050p58; -.
DR   eggNOG; ENOG502QVFP; Eukaryota.
DR   HOGENOM; CLU_033723_0_0_1; -.
DR   InParanoid; A7TEV4; -.
DR   OMA; NLNESWY; -.
DR   OrthoDB; 618092at2759; -.
DR   PhylomeDB; A7TEV4; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..532
FT                   /note="Maintenance of telomere capping protein 6"
FT                   /id="PRO_0000407783"
FT   TOPO_DOM        24..487
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        488..508
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        509..532
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        26
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        114
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        151
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        163
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        169
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        211
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        253
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        260
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        322
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        328
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        368
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        441
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        479
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   532 AA;  60421 MW;  67239B57F5FB3561 CRC64;
     MIVMQLQQQL LIWVIFWLNY ATALTNFTWS SDSPSMVYAL RAQRDVMSSA TIDQLPLVGV
     DVGRVFINGM VIENKDEDEE DEDLLVMLES LLEAGVQALS VDVEYKDEIW VVGNSTIAFD
     DFLLTVRDFL DGTNTDLSAN ILMVMLRIQP NSSDYGSPST FNNYTHGYNY SDISDYNKDD
     IGDASDIEAL IYSNIGRSYI YSPEDLVDDR NKSYTSDIYG LNSVNGWPTL SHFLYQKRKR
     VLFTELTTEM PYNTSSLLFN KTILHLDGGN IAISCPTSNS ELTELSLVAW RFIENEFTDD
     SVRSYVDCGY SPIIANKYNQ NNITHLLNLT QSALLWSWEV GQPSTNEKKN SDTLEAYNCV
     SFVYTANNYS AYWKVENCYD EKKGLCEAKT DLFSYIVSEN VDSYFNFDSF DGSNCPDGFD
     FSIPKTPLEQ LAVINYLRLR NSSDTEIWID LNSISVNNCW VTGGPYATCP YETVMSRRNF
     TKMITPASIT SFGLLVLVTC LNLLSLPIHD NRSNWRRMIN KLSRNEFDGV PA