MTCH1_MOUSE
ID MTCH1_MOUSE Reviewed; 389 AA.
AC Q791T5; Q3U4W7; Q791V6; Q8R0T0; Q8R1T8; Q8R2T2; Q9QZA5; Q9QZP4;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Mitochondrial carrier homolog 1;
DE AltName: Full=Mitochondrial carrier-like protein 1;
GN Name=Mtch1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2).
RA Jang J.S., Hahn Y., Park C., Chung J.H.;
RT "Evolutionarily conserved mitochondrial carrier gene family in mouse,
RT human, and zebrafish.";
RL Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RA Brathwaite M.E., Waeltz P., Qian Y., Dudekula D., Schlessinger D.,
RA Nagaraja R.;
RT "Genomic sequence analysis in the mouse T-complex region.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-389 (ISOFORM 2).
RC STRAIN=NOD; TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 15-389 (ISOFORM 1), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 13-389 (ISOFORM 2).
RC STRAIN=FVB/N; TISSUE=Kidney, and Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, Kidney, and Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [6]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-29, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Embryo;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- FUNCTION: Potential mitochondrial transporter. May play a role in
CC apoptosis (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with PSEN1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000305};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q791T5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q791T5-2; Sequence=VSP_017883;
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH23135.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAH26436.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAH27274.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAE32313.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB040292; BAA92860.1; -; Genomic_DNA.
DR EMBL; AB040292; BAA92861.1; -; Genomic_DNA.
DR EMBL; AF176007; AAD52645.2; -; mRNA.
DR EMBL; AF192558; AAF12792.2; -; mRNA.
DR EMBL; AY301264; AAP45196.1; -; Genomic_DNA.
DR EMBL; AY301264; AAP45202.1; -; Genomic_DNA.
DR EMBL; AK154010; BAE32313.1; ALT_INIT; mRNA.
DR EMBL; BC023135; AAH23135.1; ALT_INIT; mRNA.
DR EMBL; BC026436; AAH26436.1; ALT_INIT; mRNA.
DR EMBL; BC027274; AAH27274.1; ALT_INIT; mRNA.
DR CCDS; CCDS28596.1; -. [Q791T5-1]
DR CCDS; CCDS84288.1; -. [Q791T5-2]
DR RefSeq; NP_001334264.1; NM_001347335.1. [Q791T5-2]
DR RefSeq; NP_063933.1; NM_019880.3. [Q791T5-1]
DR RefSeq; XP_006524731.1; XM_006524668.1. [Q791T5-1]
DR RefSeq; XP_006524733.1; XM_006524670.1. [Q791T5-2]
DR AlphaFoldDB; Q791T5; -.
DR BioGRID; 208001; 1.
DR STRING; 10090.ENSMUSP00000093077; -.
DR iPTMnet; Q791T5; -.
DR PhosphoSitePlus; Q791T5; -.
DR SwissPalm; Q791T5; -.
DR EPD; Q791T5; -.
DR jPOST; Q791T5; -.
DR MaxQB; Q791T5; -.
DR PaxDb; Q791T5; -.
DR PeptideAtlas; Q791T5; -.
DR PRIDE; Q791T5; -.
DR ProteomicsDB; 287624; -. [Q791T5-1]
DR ProteomicsDB; 287625; -. [Q791T5-2]
DR Antibodypedia; 3010; 150 antibodies from 25 providers.
DR DNASU; 56462; -.
DR Ensembl; ENSMUST00000095427; ENSMUSP00000093077; ENSMUSG00000024012. [Q791T5-1]
DR Ensembl; ENSMUST00000118366; ENSMUSP00000113021; ENSMUSG00000024012. [Q791T5-2]
DR GeneID; 56462; -.
DR KEGG; mmu:56462; -.
DR UCSC; uc008bst.1; mouse. [Q791T5-1]
DR UCSC; uc008bsu.1; mouse. [Q791T5-2]
DR CTD; 23787; -.
DR MGI; MGI:1929261; Mtch1.
DR VEuPathDB; HostDB:ENSMUSG00000024012; -.
DR eggNOG; KOG2745; Eukaryota.
DR GeneTree; ENSGT00390000000020; -.
DR HOGENOM; CLU_058300_1_0_1; -.
DR InParanoid; Q791T5; -.
DR OMA; KVGHEPM; -.
DR OrthoDB; 1439019at2759; -.
DR PhylomeDB; Q791T5; -.
DR TreeFam; TF313721; -.
DR BioGRID-ORCS; 56462; 4 hits in 73 CRISPR screens.
DR ChiTaRS; Mtch1; mouse.
DR PRO; PR:Q791T5; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q791T5; protein.
DR Bgee; ENSMUSG00000024012; Expressed in saccule of membranous labyrinth and 264 other tissues.
DR ExpressionAtlas; Q791T5; baseline and differential.
DR Genevisible; Q791T5; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 1.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Apoptosis; Membrane; Methylation; Mitochondrion;
KW Mitochondrion outer membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..389
FT /note="Mitochondrial carrier homolog 1"
FT /id="PRO_0000232386"
FT TRANSMEM 248..268
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 81..176
FT /note="Solcar 1"
FT REPEAT 192..280
FT /note="Solcar 2"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 29
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT VAR_SEQ 286..302
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072, ECO:0000303|Ref.1"
FT /id="VSP_017883"
FT CONFLICT 10
FT /note="P -> A (in Ref. 3; BAE32313)"
FT /evidence="ECO:0000305"
FT CONFLICT 46
FT /note="A -> G (in Ref. 3; BAE32313)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 389 AA; 41565 MW; CCD3B23B6DF3CB02 CRC64;
MGASDPEVAP WAPGGAAGMA GAGAGAGARG GAPAGVEARA RDPPPAHRAH PRHPRPAAQP
SARRMDGGPG APGSGDNAPT TEALFVALGA GVTALSHPLL YVKLLIQVGH EPMPPTLGTN
VLGRKVLYLP SFFTYAKYIV QVDGKIGLFR GLSPRLMSNA LSTVTRGSMK KVFPPDEMEQ
VSNKDDMKTS LKKVVKETSY EMMMQCVSRM LAHPLHVISM RCMVQFVGRE AKYSGVLSSI
GKIFKEEGLL GFFVGLIPHL LGDVVFLWGC NLLAHFINAY LVDDSVSDTP GGLGNDQNPG
SQFSQALAIR SYTKFVMGIA VSMLTYPFLL VGDLMAVNNC GLRAGLPPYS PVFKSWIHCW
KYLSVQGQLF RGSSLLFRRV SSGSCFALE
