ID   MTCH2_BOVIN             Reviewed;         303 AA.
AC   Q9N285; A6QR21; F1MR38; Q5E9I9;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-FEB-2022, sequence version 3.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Mitochondrial carrier homolog 2;
GN   Name=MTCH2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Jang J.S., Hahn Y., Park C., Chung J.H.;
RT   "Identification of an evolutionary conserved mitochondrial carrier family
RT   from various organisms.";
RL   Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays important roles in regulating apoptosis, metabolism and
CC       mitochondrial dynamics. MTCH2 acts as a receptor for the truncated form
CC       of pro-apoptotic BH3-interacting domain death agonist (p15 BID) and has
CC       therefore a critical function in apoptosis. Plays a critical role in
CC       controlling the quiescence/cycling of hematopoietic stem cells (HSCs).
CC       Acts as a regulator of mitochondrial fusion, essential for the naive-
CC       to-primed interconversion of embryonic stem cells (ESCs). Acts as a
CC       regulator of lipid homeostasis and has a regulatory role in adipocyte
CC       differentiation and biology. {ECO:0000250|UniProtKB:Q791V5}.
CC   -!- SUBUNIT: Interacts with p15BID. {ECO:0000250|UniProtKB:Q791V5}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC       {ECO:0000250|UniProtKB:Q791V5}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; AB042815; BAA95942.1; -; mRNA.
DR   EMBL; BT020931; AAX08948.1; -; mRNA.
DR   EMBL; BC150080; AAI50081.1; -; mRNA.
DR   RefSeq; NP_001304265.1; NM_001317336.1.
DR   RefSeq; NP_788807.2; NM_176634.3.
DR   AlphaFoldDB; Q9N285; -.
DR   STRING; 9913.ENSBTAP00000024956; -.
DR   PaxDb; Q9N285; -.
DR   PRIDE; Q9N285; -.
DR   Ensembl; ENSBTAT00000024956; ENSBTAP00000024956; ENSBTAG00000018742.
DR   GeneID; 337927; -.
DR   KEGG; bta:337927; -.
DR   CTD; 23788; -.
DR   VGNC; VGNC:31717; MTCH2.
DR   eggNOG; KOG2745; Eukaryota.
DR   GeneTree; ENSGT00390000000020; -.
DR   HOGENOM; CLU_058300_2_0_1; -.
DR   InParanoid; Q9N285; -.
DR   OrthoDB; 1439019at2759; -.
DR   TreeFam; TF313721; -.
DR   Proteomes; UP000009136; Chromosome 15.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB.
DR   GO; GO:0055088; P:lipid homeostasis; ISS:UniProtKB.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
DR   GO; GO:2000738; P:positive regulation of stem cell differentiation; ISS:UniProtKB.
DR   GO; GO:0070585; P:protein localization to mitochondrion; IEA:Ensembl.
DR   GO; GO:0010635; P:regulation of mitochondrial fusion; ISS:UniProtKB.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 1.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 2.
PE   2: Evidence at transcript level;
KW   Acetylation; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW   Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y6C9"
FT   CHAIN           2..303
FT                   /note="Mitochondrial carrier homolog 2"
FT                   /id="PRO_0000090636"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REPEAT          2..98
FT                   /note="Solcar 1"
FT   REPEAT          118..206
FT                   /note="Solcar 2"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y6C9"
FT   CONFLICT        82
FT                   /note="V -> I (in Ref. 2; AAX08948)"
FT   CONFLICT        165
FT                   /note="S -> F (in Ref. 1; BAA95942)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        261
FT                   /note="I -> V (in Ref. 3; AAI50081)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   303 AA;  33280 MW;  7CE7BB9E0940D127 CRC64;
     MADAASQVLL GSGLTILSQP LMYVKVLIQV GYEPLAPTVG RNIFGRQVCQ LPGLFCYAQH
     IASIDGKRGL FTGLTPRLCS GVLGTVVHGK VLQHYQECDK AEESGSGNVQ KEVSSSFDRV
     IKETTREMMA RSAATLITHP FHVITLRSMV QFIGRESKYC GLCDSIATIY REEGILGFFA
     GLIPRLLGDI ISLWLCNSLA YLVNTYALDS GVSTMNEMKS YSQAVTGFFA SMLTYPFVLV
     SNLMAVNNCG LAGGCPPYAP IYSSWIDCWC MLQKEGNMSR GNSLFFRKVP FGKTYCCDLR
     MLI