ID   MTCH2_PONAB             Reviewed;         303 AA.
AC   Q5R5M0; Q5RAJ9;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 2.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Mitochondrial carrier homolog 2;
GN   Name=MTCH2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays important roles in regulating apoptosis, metabolism and
CC       mitochondrial dynamics. MTCH2 acts as a receptor for the truncated form
CC       of pro-apoptotic BH3-interacting domain death agonist (p15 BID) and has
CC       therefore a critical function in apoptosis. Plays a critical role in
CC       controlling the quiescence/cycling of hematopoietic stem cells (HSCs).
CC       Acts as a regulator of mitochondrial fusion, essential for the naive-
CC       to-primed interconversion of embryonic stem cells (ESCs). Acts as a
CC       regulator of lipid homeostasis and has a regulatory role in adipocyte
CC       differentiation and biology. {ECO:0000250|UniProtKB:Q791V5}.
CC   -!- SUBUNIT: Interacts with p15BID. {ECO:0000250|UniProtKB:Q791V5}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC       {ECO:0000250|UniProtKB:Q791V5}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q5R5M0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5R5M0-2; Sequence=VSP_013814;
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
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DR   EMBL; CR859016; CAH91211.1; -; mRNA.
DR   EMBL; CR860837; CAH92946.1; -; mRNA.
DR   RefSeq; NP_001127387.1; NM_001133915.1. [Q5R5M0-2]
DR   RefSeq; NP_001128884.1; NM_001135412.1.
DR   RefSeq; XP_009244656.1; XM_009246381.1. [Q5R5M0-1]
DR   AlphaFoldDB; Q5R5M0; -.
DR   STRING; 9601.ENSPPYP00000003778; -.
DR   Ensembl; ENSPPYT00000003925; ENSPPYP00000003778; ENSPPYG00000003296. [Q5R5M0-1]
DR   Ensembl; ENSPPYT00000047954; ENSPPYP00000025265; ENSPPYG00000003296. [Q5R5M0-2]
DR   GeneID; 100174454; -.
DR   GeneID; 100189817; -.
DR   KEGG; pon:100174454; -.
DR   CTD; 23788; -.
DR   eggNOG; KOG2745; Eukaryota.
DR   GeneTree; ENSGT00390000000020; -.
DR   HOGENOM; CLU_058300_2_0_1; -.
DR   InParanoid; Q5R5M0; -.
DR   Proteomes; UP000001595; Chromosome 11.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB.
DR   GO; GO:0055088; P:lipid homeostasis; ISS:UniProtKB.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
DR   GO; GO:2000738; P:positive regulation of stem cell differentiation; ISS:UniProtKB.
DR   GO; GO:0070585; P:protein localization to mitochondrion; IEA:Ensembl.
DR   GO; GO:0010635; P:regulation of mitochondrial fusion; ISS:UniProtKB.
DR   Gene3D; 1.50.40.10; -; 1.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   Pfam; PF00153; Mito_carr; 1.
DR   SUPFAM; SSF103506; SSF103506; 1.
DR   PROSITE; PS50920; SOLCAR; 2.
PE   2: Evidence at transcript level;
KW   Acetylation; Alternative splicing; Membrane; Mitochondrion;
KW   Mitochondrion outer membrane; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y6C9"
FT   CHAIN           2..303
FT                   /note="Mitochondrial carrier homolog 2"
FT                   /id="PRO_0000090639"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REPEAT          2..98
FT                   /note="Solcar 1"
FT   REPEAT          118..206
FT                   /note="Solcar 2"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y6C9"
FT   VAR_SEQ         94..102
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_013814"
FT   CONFLICT        62
FT                   /note="A -> T (in Ref. 1; CAH92946)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        152
FT                   /note="F -> C (in Ref. 1; CAH92946)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   303 AA;  33331 MW;  339087A8AF4A4508 CRC64;
     MADAASQVLL GSGLTILSQP LMYVKVLIQV GYEPLPPTIG RNIFGRQVCQ LPGLFSYAQH
     IASIDGRRGL FTGLTPRLCS GVLGTVVHGK VLQHYQESDK GEELGPGNVQ KEVSSSFDHV
     IKETTREMIA RSAATLITHP FHVITLRSMV QFIGRESKYC GLCDSIITIY REEGILGFFA
     GLVPRLLGDI LSLWLCNSLA YLVNTYALDS GVSTMNEMKS YSQAVTGFFA SMLTYPFVLV
     SNLMAVNNCG LAGGCPPYSP IYTSWIDCWC MLQKEGNMSR GNSLFFRKVP FGKTYCCDLK
     MLI