MTCP1_MOUSE
ID MTCP1_MOUSE Reviewed; 107 AA.
AC Q60945; A3KGA7;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Protein p13 MTCP-1;
DE Short=p13MTCP1;
DE AltName: Full=Mature T-cell proliferation-1 type B1;
DE Short=MTCP-1 type B1;
GN Name=Mtcp1; Synonyms=C6.1b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=T-cell;
RX PubMed=8634440;
RA Madani A., Choukroun V., Soulier J., Cacheux V., Claisse J.-F., Valensi F.,
RA Daliphard S., Cazin B., Levy V., Leblond V., Daniel M.-T., Sigaux F.,
RA Stern M.-H.;
RT "Expression of p13MTCP1 is restricted to mature T-cell proliferations with
RT t(X;14) translocations.";
RL Blood 87:1923-1927(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Enhances the phosphorylation and activation of AKT1 and AKT2.
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with AKT1 and AKT2 (via PH domain). Does not
CC interact with AKT3 (By similarity). {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=2; Synonyms=Long, Type B1, p13 MTCP-1;
CC IsoId=Q60945-1; Sequence=Displayed;
CC Name=1; Synonyms=Short, Type A, p8 MTCP-1;
CC IsoId=Q61908-1; Sequence=External;
CC -!- TISSUE SPECIFICITY: Not found at a significant level in any tissue.
CC -!- MISCELLANEOUS: [Isoform 2]: Shares a non-coding 5' exon with isoform 1
CC which is spliced to a different set of 3' exons encoding an unrelated
CC protein.
CC -!- SIMILARITY: Belongs to the TCL1 family. {ECO:0000305}.
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DR EMBL; U32332; AAC52444.1; -; mRNA.
DR EMBL; AL671860; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS30241.1; -. [Q60945-1]
DR RefSeq; NP_001034462.1; NM_001039373.5. [Q60945-1]
DR AlphaFoldDB; Q60945; -.
DR SMR; Q60945; -.
DR STRING; 10090.ENSMUSP00000033542; -.
DR PaxDb; Q60945; -.
DR PRIDE; Q60945; -.
DR ProteomicsDB; 290107; -. [Q60945-1]
DR Antibodypedia; 31399; 62 antibodies from 13 providers.
DR DNASU; 17763; -.
DR Ensembl; ENSMUST00000033542; ENSMUSP00000033542; ENSMUSG00000031200. [Q60945-1]
DR Ensembl; ENSMUST00000114081; ENSMUSP00000109715; ENSMUSG00000031200. [Q60945-1]
DR GeneID; 17763; -.
DR KEGG; mmu:17763; -.
DR UCSC; uc009tpw.2; mouse. [Q60945-1]
DR CTD; 4515; -.
DR MGI; MGI:102699; Mtcp1.
DR VEuPathDB; HostDB:ENSMUSG00000031200; -.
DR eggNOG; ENOG502S5U8; Eukaryota.
DR GeneTree; ENSGT00390000006885; -.
DR HOGENOM; CLU_168379_0_0_1; -.
DR InParanoid; Q60945; -.
DR OMA; REGIYRD; -.
DR OrthoDB; 1496659at2759; -.
DR PhylomeDB; Q60945; -.
DR TreeFam; TF337903; -.
DR BioGRID-ORCS; 17763; 3 hits in 70 CRISPR screens.
DR ChiTaRS; Mtcp1; mouse.
DR PRO; PR:Q60945; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q60945; protein.
DR Bgee; ENSMUSG00000031200; Expressed in saccule of membranous labyrinth and 178 other tissues.
DR Genevisible; Q60945; MM.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0032991; C:protein-containing complex; ISO:MGI.
DR GO; GO:0019901; F:protein kinase binding; ISO:MGI.
DR GO; GO:0043539; F:protein serine/threonine kinase activator activity; ISO:MGI.
DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IBA:GO_Central.
DR Gene3D; 2.40.15.10; -; 1.
DR InterPro; IPR004832; TCL1_MTCP1.
DR InterPro; IPR036672; TCL1_MTCP1_sf.
DR PANTHER; PTHR14060; PTHR14060; 1.
DR Pfam; PF01840; TCL1_MTCP1; 1.
DR SUPFAM; SSF50904; SSF50904; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..107
FT /note="Protein p13 MTCP-1"
FT /id="PRO_0000184487"
SQ SEQUENCE 107 AA; 12645 MW; 7996813A182C2308 CRC64;
MAREDVGAPP DHLWVHQEGV YRDEYQRTWV AVVEEETSFL KARVQQVQVP LGDATKPSHL
LTSQLPLMWQ LYPEERYMDN NSRLWQIQHH LMVRGVQELL LKLLPDD
