MTCU_CALSI
ID MTCU_CALSI Reviewed; 64 AA.
AC Q9U620;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 50.
DE RecName: Full=Copper-specific metallothionein-2;
DE AltName: Full=CuMT-II;
OS Callinectes sapidus (Blue crab).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Brachyura;
OC Eubrachyura; Portunoidea; Portunidae; Callinectes.
OX NCBI_TaxID=6763;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11790353; DOI=10.1016/s0742-8413(99)00114-0;
RA Syring R.A., Hoexum-Brouwer T.H., Brouwer M.;
RT "Cloning and sequencing of cDNAs encoding for a novel copper-specific
RT metallothionein and two cadmium-inducible metallothioneins from the blue
RT crab Callinectes sapidus.";
RL Comp. Biochem. Physiol. 125C:325-332(2000).
CC -!- FUNCTION: The metallothioneins are involved in the cellular
CC sequestration of toxic metal ions and regulation of essential trace
CC elements. This isoform binds exclusively copper.
CC -!- DOMAIN: 14 cysteine residues are arranged in C-X-C groups. These are
CC thought to be the metal-binding sites in other metallothioneins.
CC -!- SIMILARITY: Belongs to the metallothionein superfamily. Type 2 family.
CC {ECO:0000305}.
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DR EMBL; AF200420; AAF08966.1; -; mRNA.
DR AlphaFoldDB; Q9U620; -.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
PE 3: Inferred from homology;
KW Copper; Metal-binding; Metal-thiolate cluster.
FT CHAIN 1..64
FT /note="Copper-specific metallothionein-2"
FT /id="PRO_0000197337"
FT BINDING 3
FT /ligand="Cu(+)"
FT /ligand_id="ChEBI:CHEBI:49552"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P55947"
FT BINDING 5
FT /ligand="Cu(+)"
FT /ligand_id="ChEBI:CHEBI:49552"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P55947"
FT BINDING 5
FT /ligand="Cu(+)"
FT /ligand_id="ChEBI:CHEBI:49552"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P55947"
FT BINDING 9
FT /ligand="Cu(+)"
FT /ligand_id="ChEBI:CHEBI:49552"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P55947"
FT BINDING 11
FT /ligand="Cu(+)"
FT /ligand_id="ChEBI:CHEBI:49552"
FT /ligand_label="3"
FT /evidence="ECO:0000250|UniProtKB:P55947"
FT BINDING 16
FT /ligand="Cu(+)"
FT /ligand_id="ChEBI:CHEBI:49552"
FT /ligand_label="3"
FT /evidence="ECO:0000250|UniProtKB:P55947"
FT BINDING 18
FT /ligand="Cu(+)"
FT /ligand_id="ChEBI:CHEBI:49552"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P55947"
FT BINDING 18
FT /ligand="Cu(+)"
FT /ligand_id="ChEBI:CHEBI:49552"
FT /ligand_label="3"
FT /evidence="ECO:0000250|UniProtKB:P55947"
FT BINDING 22
FT /ligand="Cu(+)"
FT /ligand_id="ChEBI:CHEBI:49552"
FT /ligand_label="1"
FT /evidence="ECO:0000250|UniProtKB:P55947"
FT BINDING 24
FT /ligand="Cu(+)"
FT /ligand_id="ChEBI:CHEBI:49552"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P55947"
FT BINDING 27
FT /ligand="Cu(+)"
FT /ligand_id="ChEBI:CHEBI:49552"
FT /ligand_label="2"
FT /evidence="ECO:0000250|UniProtKB:P55947"
FT BINDING 27
FT /ligand="Cu(+)"
FT /ligand_id="ChEBI:CHEBI:49552"
FT /ligand_label="3"
FT /evidence="ECO:0000250|UniProtKB:P55947"
FT BINDING 33
FT /ligand="Cu(+)"
FT /ligand_id="ChEBI:CHEBI:49552"
FT /ligand_label="5"
FT /evidence="ECO:0000250|UniProtKB:P55947"
FT BINDING 40
FT /ligand="Cu(+)"
FT /ligand_id="ChEBI:CHEBI:49552"
FT /ligand_label="5"
FT /evidence="ECO:0000250|UniProtKB:P55947"
FT BINDING 40
FT /ligand="Cu(+)"
FT /ligand_id="ChEBI:CHEBI:49552"
FT /ligand_label="6"
FT /evidence="ECO:0000250|UniProtKB:P55947"
FT BINDING 44
FT /ligand="Cu(+)"
FT /ligand_id="ChEBI:CHEBI:49552"
FT /ligand_label="4"
FT /evidence="ECO:0000250|UniProtKB:P55947"
FT BINDING 44
FT /ligand="Cu(+)"
FT /ligand_id="ChEBI:CHEBI:49552"
FT /ligand_label="5"
FT /evidence="ECO:0000250|UniProtKB:P55947"
FT BINDING 50
FT /ligand="Cu(+)"
FT /ligand_id="ChEBI:CHEBI:49552"
FT /ligand_label="4"
FT /evidence="ECO:0000250|UniProtKB:P55947"
FT BINDING 52
FT /ligand="Cu(+)"
FT /ligand_id="ChEBI:CHEBI:49552"
FT /ligand_label="6"
FT /evidence="ECO:0000250|UniProtKB:P55947"
FT BINDING 56
FT /ligand="Cu(+)"
FT /ligand_id="ChEBI:CHEBI:49552"
FT /ligand_label="6"
FT /evidence="ECO:0000250|UniProtKB:P55947"
FT BINDING 58
FT /ligand="Cu(+)"
FT /ligand_id="ChEBI:CHEBI:49552"
FT /ligand_label="4"
FT /evidence="ECO:0000250|UniProtKB:P55947"
FT BINDING 58
FT /ligand="Cu(+)"
FT /ligand_id="ChEBI:CHEBI:49552"
FT /ligand_label="6"
FT /evidence="ECO:0000250|UniProtKB:P55947"
SQ SEQUENCE 64 AA; 6277 MW; B0B8767AD6CE978A CRC64;
MPCGCGTSCK CGSGKCCCGS TCNCTTCPSK QSCSCNDGAC GSACQCKTSC CCGADCKCSP
CPMK
