MTD1_CAEEL
ID MTD1_CAEEL Reviewed; 278 AA.
AC G5ECI1;
DT 29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 1.
DT 03-AUG-2022, entry version 53.
DE RecName: Full=Protein mtd-1 {ECO:0000305};
DE AltName: Full=Mec three-dependent expression protein 1 {ECO:0000303|PubMed:12385749, ECO:0000312|WormBase:ZK337.5};
DE Flags: Precursor;
GN Name=mtd-1 {ECO:0000303|PubMed:12385749, ECO:0000312|WormBase:ZK337.5};
GN ORFNames=ZK337.5 {ECO:0000312|WormBase:ZK337.5};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=12385749; DOI=10.1016/s0925-4773(02)00293-9;
RA Zhang Y., Chalfie M.;
RT "MTD-1, a touch-cell-specific membrane protein with a subtle effect on
RT touch sensitivity.";
RL Mech. Dev. 119:3-7(2002).
CC -!- FUNCTION: Plays a role in mechanosensory transduction (touch
CC sensitivity). {ECO:0000269|PubMed:12385749}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12385749};
CC Single-pass type I membrane protein {ECO:0000255}; Extracellular side
CC {ECO:0000305|PubMed:12385749}.
CC -!- DEVELOPMENTAL STAGE: Expressed in embryos and larva (PubMed:12385749).
CC In L2 and L3 stage larva, expressed in the six touch receptor neurons
CC (PubMed:12385749). {ECO:0000269|PubMed:12385749}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in no visible
CC phenotype (PubMed:12385749). RNAi-mediated knockdown enhances the
CC touch-insensitive phenotype (the inability to respond to more than two
CC of four touches) of mec-6 u247ts mutants at 15 degrees Celsius
CC (PubMed:12385749). {ECO:0000269|PubMed:12385749}.
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DR EMBL; BX284601; CAB51468.1; -; Genomic_DNA.
DR PIR; T21718; T21718.
DR RefSeq; NP_493615.1; NM_061214.6.
DR AlphaFoldDB; G5ECI1; -.
DR STRING; 6239.ZK337.5; -.
DR PaxDb; G5ECI1; -.
DR PeptideAtlas; G5ECI1; -.
DR EnsemblMetazoa; ZK337.5.1; ZK337.5.1; WBGene00003471.
DR GeneID; 191285; -.
DR KEGG; cel:CELE_ZK337.5; -.
DR CTD; 191285; -.
DR WormBase; ZK337.5; CE24721; WBGene00003471; mtd-1.
DR eggNOG; ENOG502TGU6; Eukaryota.
DR HOGENOM; CLU_991237_0_0_1; -.
DR InParanoid; G5ECI1; -.
DR OMA; CQGHNIW; -.
DR OrthoDB; 1112437at2759; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00003471; Expressed in larva and 2 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:1905789; P:positive regulation of detection of mechanical stimulus involved in sensory perception of touch; IGI:UniProtKB.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..278
FT /note="Protein mtd-1"
FT /id="PRO_5003475913"
FT TOPO_DOM 18..254
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 255..271
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 272..278
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT CARBOHYD 40
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 73
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 163
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 190
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 278 AA; 31379 MW; 342FF46610ACA3AE CRC64;
MRSSLLLLVF FLSIGWARYC VHNEKSWCQG HNIWGWCFHN KSSGVFNCDD NAFCVSQEQL
KNKKSSGCFL RDNSSICCCN DADGCNLGFI GVQPKYAHGQ QCTNSMEVPN EDIRQFRPCD
DPFCYSVLTA EDDGGPTTVT RGCHSRKMVM HHMSKNEDDK YQNNTKWRET KQIAEMPSCA
EILKDQPKVN GTTSMCVDFT YDQEAEDGEE VDEPIKMKGR LCCCAGSNKC NEHAMWADEG
ISLTEMLEEI EARKVPVDSS APVNIILSIA FSIFLIHF
