MTD_METM7
ID MTD_METM7 Reviewed; 277 AA.
AC A6VJ05;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 25-MAY-2022, entry version 68.
DE RecName: Full=F420-dependent methylenetetrahydromethanopterin dehydrogenase {ECO:0000255|HAMAP-Rule:MF_00058};
DE Short=MTD {ECO:0000255|HAMAP-Rule:MF_00058};
DE EC=1.5.98.1 {ECO:0000255|HAMAP-Rule:MF_00058};
DE AltName: Full=Coenzyme F420-dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase {ECO:0000255|HAMAP-Rule:MF_00058};
GN Name=mtd {ECO:0000255|HAMAP-Rule:MF_00058}; OrderedLocusNames=MmarC7_1368;
OS Methanococcus maripaludis (strain C7 / ATCC BAA-1331).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanococcaceae; Methanococcus.
OX NCBI_TaxID=426368;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C7 / ATCC BAA-1331;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Clum A., Schmutz J., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Anderson I., Sieprawska-Lupa M., Whitman W.B., Richardson P.;
RT "Complete sequence of Methanococcus maripaludis C7.";
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to
CC methylene-H(4)MPT. {ECO:0000255|HAMAP-Rule:MF_00058}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5,10-methylenetetrahydromethanopterin + 2 H(+) + oxidized
CC coenzyme F420-(gamma-L-Glu)(n) = 5,10-methenyl-5,6,7,8-
CC tetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n);
CC Xref=Rhea:RHEA:16721, Rhea:RHEA-COMP:12939, Rhea:RHEA-COMP:14378,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57818, ChEBI:CHEBI:58337,
CC ChEBI:CHEBI:133980, ChEBI:CHEBI:139511; EC=1.5.98.1;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00058};
CC -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-
CC methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8-
CC tetrahydromethanopterin (coenzyme F420 route): step 1/1.
CC {ECO:0000255|HAMAP-Rule:MF_00058}.
CC -!- SIMILARITY: Belongs to the MTD family. {ECO:0000255|HAMAP-
CC Rule:MF_00058}.
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DR EMBL; CP000745; ABR66431.1; -; Genomic_DNA.
DR RefSeq; WP_012067898.1; NC_009637.1.
DR AlphaFoldDB; A6VJ05; -.
DR SMR; A6VJ05; -.
DR STRING; 426368.MmarC7_1368; -.
DR EnsemblBacteria; ABR66431; ABR66431; MmarC7_1368.
DR GeneID; 5329191; -.
DR KEGG; mmz:MmarC7_1368; -.
DR eggNOG; arCOG04382; Archaea.
DR HOGENOM; CLU_1006890_0_0_2; -.
DR OMA; KGCFMTK; -.
DR OrthoDB; 46875at2157; -.
DR UniPathway; UPA00640; UER00695.
DR GO; GO:0008901; F:ferredoxin hydrogenase activity; IEA:InterPro.
DR GO; GO:0030268; F:methylenetetrahydromethanopterin dehydrogenase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00058; MTD; 1.
DR InterPro; IPR002844; MTD.
DR InterPro; IPR036080; MTD_sf.
DR Pfam; PF01993; MTD; 1.
DR PIRSF; PIRSF005627; MTD; 1.
DR SUPFAM; SSF102324; SSF102324; 1.
PE 3: Inferred from homology;
KW Methanogenesis; One-carbon metabolism; Oxidoreductase.
FT CHAIN 1..277
FT /note="F420-dependent methylenetetrahydromethanopterin
FT dehydrogenase"
FT /id="PRO_1000007672"
SQ SEQUENCE 277 AA; 29879 MW; 663CB9074D2C14E9 CRC64;
MVVKIGILKC GNIGMSPVVD LCLDERADRN DIDVRVLGSG AKMGPEQVEE VAKKMVEEVK
PDFIVYIGPN PAAPGPKKAR EILSAGGIPT VIIGDAPGIK DKDAMAEEGL GYVLIKCDPM
IGARRQFLDP VEMAMFNADV IRVLAGTGAL RVVQNAIDDM VFAVEEGKEI PLPKIVITEQ
KAVDAMDFAN PYAKAKAMAA FVMAEKVADI DVKGCFMTKE MEKYIPIVAS AHEAIRYAAK
LVDEARELEK ATDAVSRKPH AGEGKILNKC KLMAKPE
