位置:首页 > 蛋白库 > MTD_METMP
MTD_METMP
ID   MTD_METMP               Reviewed;         277 AA.
AC   Q6M099;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=F420-dependent methylenetetrahydromethanopterin dehydrogenase {ECO:0000255|HAMAP-Rule:MF_00058};
DE            Short=MTD {ECO:0000255|HAMAP-Rule:MF_00058};
DE            EC=1.5.98.1 {ECO:0000255|HAMAP-Rule:MF_00058};
DE   AltName: Full=Coenzyme F420-dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase {ECO:0000255|HAMAP-Rule:MF_00058};
GN   Name=mtd {ECO:0000255|HAMAP-Rule:MF_00058}; OrderedLocusNames=MMP0372;
OS   Methanococcus maripaludis (strain S2 / LL).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=267377;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S2 / LL;
RX   PubMed=15466049; DOI=10.1128/jb.186.20.6956-6969.2004;
RA   Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J.,
RA   Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M.,
RA   Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A.,
RA   Moore B.C., Porat I., Palmeiri A., Rouse G., Saenphimmachak C., Soell D.,
RA   Van Dien S., Wang T., Whitman W.B., Xia Q., Zhang Y., Larimer F.W.,
RA   Olson M.V., Leigh J.A.;
RT   "Complete genome sequence of the genetically tractable hydrogenotrophic
RT   methanogen Methanococcus maripaludis.";
RL   J. Bacteriol. 186:6956-6969(2004).
CC   -!- FUNCTION: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to
CC       methylene-H(4)MPT. {ECO:0000255|HAMAP-Rule:MF_00058}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5,10-methylenetetrahydromethanopterin + 2 H(+) + oxidized
CC         coenzyme F420-(gamma-L-Glu)(n) = 5,10-methenyl-5,6,7,8-
CC         tetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n);
CC         Xref=Rhea:RHEA:16721, Rhea:RHEA-COMP:12939, Rhea:RHEA-COMP:14378,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57818, ChEBI:CHEBI:58337,
CC         ChEBI:CHEBI:133980, ChEBI:CHEBI:139511; EC=1.5.98.1;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00058};
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-
CC       methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8-
CC       tetrahydromethanopterin (coenzyme F420 route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00058}.
CC   -!- SIMILARITY: Belongs to the MTD family. {ECO:0000255|HAMAP-
CC       Rule:MF_00058}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BX950229; CAF29928.1; -; Genomic_DNA.
DR   RefSeq; WP_011170316.1; NC_005791.1.
DR   AlphaFoldDB; Q6M099; -.
DR   SMR; Q6M099; -.
DR   STRING; 267377.MMP0372; -.
DR   EnsemblBacteria; CAF29928; CAF29928; MMP0372.
DR   GeneID; 41278808; -.
DR   KEGG; mmp:MMP0372; -.
DR   PATRIC; fig|267377.15.peg.376; -.
DR   eggNOG; arCOG04382; Archaea.
DR   HOGENOM; CLU_1006890_0_0_2; -.
DR   OMA; KGCFMTK; -.
DR   OrthoDB; 46875at2157; -.
DR   BioCyc; MMAR267377:MMP_RS01985-MON; -.
DR   UniPathway; UPA00640; UER00695.
DR   Proteomes; UP000000590; Chromosome.
DR   GO; GO:0008901; F:ferredoxin hydrogenase activity; IEA:InterPro.
DR   GO; GO:0030268; F:methylenetetrahydromethanopterin dehydrogenase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00058; MTD; 1.
DR   InterPro; IPR002844; MTD.
DR   InterPro; IPR036080; MTD_sf.
DR   Pfam; PF01993; MTD; 1.
DR   PIRSF; PIRSF005627; MTD; 1.
DR   SUPFAM; SSF102324; SSF102324; 1.
PE   3: Inferred from homology;
KW   Methanogenesis; One-carbon metabolism; Oxidoreductase; Reference proteome.
FT   CHAIN           1..277
FT                   /note="F420-dependent methylenetetrahydromethanopterin
FT                   dehydrogenase"
FT                   /id="PRO_1000007673"
SQ   SEQUENCE   277 AA;  29907 MW;  D27D31AFE0011C79 CRC64;
     MVVKIGILKC GNIGMSPVVD LCLDERADRN DIDVRVLGSG AKMGPEQVEE VAKKMVEEIK
     PDFIVYIGPN PAAPGPKKAR EILSAGGIPA VIIGDAPGIK DKDAMAEEGL GYVLIKCDPM
     IGARRQFLDP VEMAMFNADV IRVLAGTGAL RVVQNAIDDM VFAVEEGKEI PLPKIVITEQ
     KAVEAMDFAN PYAKAKAMAA FVMAEKVADI DVKGCFMTKE MEKYIPIVAS AHETIRYAAK
     LVDEARELEK ATDAVSRKPH AGAGKILNKC KLMEKPE
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024