MTD_METMP
ID MTD_METMP Reviewed; 277 AA.
AC Q6M099;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=F420-dependent methylenetetrahydromethanopterin dehydrogenase {ECO:0000255|HAMAP-Rule:MF_00058};
DE Short=MTD {ECO:0000255|HAMAP-Rule:MF_00058};
DE EC=1.5.98.1 {ECO:0000255|HAMAP-Rule:MF_00058};
DE AltName: Full=Coenzyme F420-dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase {ECO:0000255|HAMAP-Rule:MF_00058};
GN Name=mtd {ECO:0000255|HAMAP-Rule:MF_00058}; OrderedLocusNames=MMP0372;
OS Methanococcus maripaludis (strain S2 / LL).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanococcaceae; Methanococcus.
OX NCBI_TaxID=267377;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S2 / LL;
RX PubMed=15466049; DOI=10.1128/jb.186.20.6956-6969.2004;
RA Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J.,
RA Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M.,
RA Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A.,
RA Moore B.C., Porat I., Palmeiri A., Rouse G., Saenphimmachak C., Soell D.,
RA Van Dien S., Wang T., Whitman W.B., Xia Q., Zhang Y., Larimer F.W.,
RA Olson M.V., Leigh J.A.;
RT "Complete genome sequence of the genetically tractable hydrogenotrophic
RT methanogen Methanococcus maripaludis.";
RL J. Bacteriol. 186:6956-6969(2004).
CC -!- FUNCTION: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to
CC methylene-H(4)MPT. {ECO:0000255|HAMAP-Rule:MF_00058}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5,10-methylenetetrahydromethanopterin + 2 H(+) + oxidized
CC coenzyme F420-(gamma-L-Glu)(n) = 5,10-methenyl-5,6,7,8-
CC tetrahydromethanopterin + reduced coenzyme F420-(gamma-L-Glu)(n);
CC Xref=Rhea:RHEA:16721, Rhea:RHEA-COMP:12939, Rhea:RHEA-COMP:14378,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57818, ChEBI:CHEBI:58337,
CC ChEBI:CHEBI:133980, ChEBI:CHEBI:139511; EC=1.5.98.1;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00058};
CC -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-
CC methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8-
CC tetrahydromethanopterin (coenzyme F420 route): step 1/1.
CC {ECO:0000255|HAMAP-Rule:MF_00058}.
CC -!- SIMILARITY: Belongs to the MTD family. {ECO:0000255|HAMAP-
CC Rule:MF_00058}.
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DR EMBL; BX950229; CAF29928.1; -; Genomic_DNA.
DR RefSeq; WP_011170316.1; NC_005791.1.
DR AlphaFoldDB; Q6M099; -.
DR SMR; Q6M099; -.
DR STRING; 267377.MMP0372; -.
DR EnsemblBacteria; CAF29928; CAF29928; MMP0372.
DR GeneID; 41278808; -.
DR KEGG; mmp:MMP0372; -.
DR PATRIC; fig|267377.15.peg.376; -.
DR eggNOG; arCOG04382; Archaea.
DR HOGENOM; CLU_1006890_0_0_2; -.
DR OMA; KGCFMTK; -.
DR OrthoDB; 46875at2157; -.
DR BioCyc; MMAR267377:MMP_RS01985-MON; -.
DR UniPathway; UPA00640; UER00695.
DR Proteomes; UP000000590; Chromosome.
DR GO; GO:0008901; F:ferredoxin hydrogenase activity; IEA:InterPro.
DR GO; GO:0030268; F:methylenetetrahydromethanopterin dehydrogenase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00058; MTD; 1.
DR InterPro; IPR002844; MTD.
DR InterPro; IPR036080; MTD_sf.
DR Pfam; PF01993; MTD; 1.
DR PIRSF; PIRSF005627; MTD; 1.
DR SUPFAM; SSF102324; SSF102324; 1.
PE 3: Inferred from homology;
KW Methanogenesis; One-carbon metabolism; Oxidoreductase; Reference proteome.
FT CHAIN 1..277
FT /note="F420-dependent methylenetetrahydromethanopterin
FT dehydrogenase"
FT /id="PRO_1000007673"
SQ SEQUENCE 277 AA; 29907 MW; D27D31AFE0011C79 CRC64;
MVVKIGILKC GNIGMSPVVD LCLDERADRN DIDVRVLGSG AKMGPEQVEE VAKKMVEEIK
PDFIVYIGPN PAAPGPKKAR EILSAGGIPA VIIGDAPGIK DKDAMAEEGL GYVLIKCDPM
IGARRQFLDP VEMAMFNADV IRVLAGTGAL RVVQNAIDDM VFAVEEGKEI PLPKIVITEQ
KAVEAMDFAN PYAKAKAMAA FVMAEKVADI DVKGCFMTKE MEKYIPIVAS AHETIRYAAK
LVDEARELEK ATDAVSRKPH AGAGKILNKC KLMEKPE