MTEF2_ARATH
ID MTEF2_ARATH Reviewed; 641 AA.
AC F4IHL3; Q9SJ27;
DT 11-MAY-2016, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 69.
DE RecName: Full=Transcription termination factor MTERF2, chloroplastic {ECO:0000305};
DE AltName: Full=Mitochondrial transcription termination factor 2 {ECO:0000303|PubMed:23087700};
DE AltName: Full=Protein EMBRYO DEFECTIVE 2219 {ECO:0000303|PubMed:15266054};
DE Flags: Precursor;
GN Name=MTERF2 {ECO:0000303|PubMed:23087700};
GN Synonyms=EMB2219 {ECO:0000303|PubMed:15266054};
GN OrderedLocusNames=At2g21710 {ECO:0000312|Araport:AT2G21710};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=15266054; DOI=10.1104/pp.104.045179;
RA Tzafrir I., Pena-Muralla R., Dickerman A., Berg M., Rogers R., Hutchens S.,
RA Sweeney T.C., McElver J., Aux G., Patton D., Meinke D.;
RT "Identification of genes required for embryo development in Arabidopsis.";
RL Plant Physiol. 135:1206-1220(2004).
RN [4]
RP SUBCELLULAR LOCATION.
RX PubMed=21464319; DOI=10.1073/pnas.1103442108;
RA Babiychuk E., Vandepoele K., Wissing J., Garcia-Diaz M., De Rycke R.,
RA Akbari H., Joubes J., Beeckman T., Jaensch L., Frentzen M.,
RA Van Montagu M.C., Kushnir S.;
RT "Plastid gene expression and plant development require a plastidic protein
RT of the mitochondrial transcription termination factor family.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:6674-6679(2011).
RN [5]
RP GENE FAMILY.
RX PubMed=23087700; DOI=10.3389/fpls.2012.00233;
RA Kleine T.;
RT "Arabidopsis thaliana mTERF proteins: evolution and functional
RT classification.";
RL Front. Plant Sci. 3:233-233(2012).
CC -!- FUNCTION: Transcription termination factor involved in processing of
CC plastid transcripts (By similarity). Essential for embryogenesis
CC (PubMed:15266054). {ECO:0000250|UniProtKB:Q9ZT96,
CC ECO:0000269|PubMed:15266054}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast
CC {ECO:0000269|PubMed:21464319}.
CC -!- DISRUPTION PHENOTYPE: Embryo defective. Developmental arrest of the
CC embryo at transition from the globular to heart stage.
CC {ECO:0000269|PubMed:15266054}.
CC -!- SIMILARITY: Belongs to the mTERF family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD20391.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAM15397.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC007019; AAD20391.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC007119; AAM15397.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC07213.1; -; Genomic_DNA.
DR PIR; C84604; C84604.
DR RefSeq; NP_179763.3; NM_127741.4.
DR AlphaFoldDB; F4IHL3; -.
DR SMR; F4IHL3; -.
DR IntAct; F4IHL3; 2.
DR STRING; 3702.AT2G21710.1; -.
DR iPTMnet; F4IHL3; -.
DR PaxDb; F4IHL3; -.
DR PRIDE; F4IHL3; -.
DR ProteomicsDB; 250808; -.
DR EnsemblPlants; AT2G21710.1; AT2G21710.1; AT2G21710.
DR GeneID; 816708; -.
DR Gramene; AT2G21710.1; AT2G21710.1; AT2G21710.
DR KEGG; ath:AT2G21710; -.
DR Araport; AT2G21710; -.
DR TAIR; locus:2049329; AT2G21710.
DR eggNOG; KOG1267; Eukaryota.
DR HOGENOM; CLU_030919_0_0_1; -.
DR InParanoid; F4IHL3; -.
DR OMA; MLLRYNI; -.
DR OrthoDB; 569251at2759; -.
DR PRO; PR:F4IHL3; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; F4IHL3; baseline and differential.
DR GO; GO:0009507; C:chloroplast; IDA:TAIR.
DR GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR GO; GO:0003690; F:double-stranded DNA binding; IEA:InterPro.
DR GO; GO:0032502; P:developmental process; IBA:GO_Central.
DR GO; GO:0006353; P:DNA-templated transcription, termination; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 1.25.70.10; -; 1.
DR InterPro; IPR003690; MTERF.
DR InterPro; IPR038538; MTERF_sf.
DR PANTHER; PTHR13068; PTHR13068; 1.
DR Pfam; PF02536; mTERF; 2.
DR SMART; SM00733; Mterf; 8.
PE 3: Inferred from homology;
KW Chloroplast; Plastid; Reference proteome; Transcription;
KW Transcription regulation; Transcription termination; Transit peptide.
FT TRANSIT 1..?
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT CHAIN ?..641
FT /note="Transcription termination factor MTERF2,
FT chloroplastic"
FT /id="PRO_0000436196"
FT REGION 54..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 606..641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..641
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 641 AA; 74745 MW; AE4D6AEECE1C6415 CRC64;
MLLHCNVSYY TSTFSFISSS LRRQDNADDS QDTVIRRRHN ARSISLYIRH NRDLKLNKNP
NESQETFVPP PPPPRRDLDG ENRSKLLELS LVTRRTPQFP GSIYAQSASD ADIASSLPSL
RNFLGSDGDD DGESEREMIV KALEIRRKVT KEIIKESLVR KGRFGITYAT NVTDRLGDFV
DHVMIQAAAL KRLPEFSESR FNLRARTVIE DSNFVPLVRW LKHHELSYNR IAKIICMSKG
NLDSIRIMIE WLKSIHVKGE FIAVAFLRSG DNILQRNREE LNEIVEYLES NGVRRDWMGY
VVGRCPELLS FSMEEVKSRV DFFLKMGMNQ NDFGTMVYDY PKIIGFFSFQ VMEKKINYLK
EFGLSTEEVG RLLAYKPHLM GCSIEERWKP LVKYFYYLGI PKEGMKRILV VKPILYCIDL
EKTIAPKVRF LQEMGIPNEA IGNMLVKFPS LLTNSLYKKI RPVVIFLLTR AGVTQKDIGK
VIAMDPALLG CSIGTKLEPN MRYYISLGIR FYQLGEMIAD FPMLLRYNVD NLRPKYRYLR
RTMIRPLQDL IEFPRFFSYS LERRIIPRHT IMVENRVNFK LRYMLACTDE EFERRVRDKV
ERRERFEAGL DSEDSQPSDE NISDQEIAFS DEAEEEEDLT E