MTEF2_MOUSE
ID MTEF2_MOUSE Reviewed; 385 AA.
AC Q8BKY8;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Transcription termination factor 2, mitochondrial;
DE AltName: Full=Mitochondrial transcription termination factor 2;
DE Short=mTERF2;
DE AltName: Full=mTERF domain-containing protein 3, mitochondrial;
DE Flags: Precursor;
GN Name=Mterf2; Synonyms=Mterfd3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Corpus striatum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP SUBCELLULAR LOCATION.
RX PubMed=19366608; DOI=10.1016/j.bbabio.2009.01.018;
RA Pellegrini M., Asin-Cayuela J., Erdjument-Bromage H., Tempst P.,
RA Larsson N.G., Gustafsson C.M.;
RT "MTERF2 is a nucleoid component in mammalian mitochondria.";
RL Biochim. Biophys. Acta 1787:296-302(2009).
RN [4]
RP RETRACTED PAPER.
RX PubMed=19490905; DOI=10.1016/j.cmet.2009.04.010;
RA Wenz T., Luca C., Torraco A., Moraes C.T.;
RT "mTERF2 regulates oxidative phosphorylation by modulating mtDNA
RT transcription.";
RL Cell Metab. 9:499-511(2009).
RN [5]
RP RETRACTION NOTICE OF PUBMED:19490905.
RX PubMed=26693524; DOI=10.1016/j.cmet.2015.09.017;
RA Wenz T., Luca C., Torraco A., Moraes C.T.;
RL Cell Metab. 22:751-751(2015).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Heart;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Binds mitochondrial DNA and plays a role in the regulation of
CC transcription of mitochondrial mRNA and rRNA species.
CC {ECO:0000250|UniProtKB:Q49AM1}.
CC -!- SUBUNIT: Monomer. {ECO:0000250|UniProtKB:Q49AM1}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix, mitochondrion nucleoid
CC {ECO:0000269|PubMed:19366608}.
CC -!- SIMILARITY: Belongs to the mTERF family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK047778; BAC33153.1; -; mRNA.
DR EMBL; BC046619; AAH46619.1; -; mRNA.
DR CCDS; CCDS24088.1; -.
DR RefSeq; NP_083108.1; NM_028832.3.
DR AlphaFoldDB; Q8BKY8; -.
DR SMR; Q8BKY8; -.
DR STRING; 10090.ENSMUSP00000062762; -.
DR iPTMnet; Q8BKY8; -.
DR PhosphoSitePlus; Q8BKY8; -.
DR EPD; Q8BKY8; -.
DR MaxQB; Q8BKY8; -.
DR PaxDb; Q8BKY8; -.
DR PeptideAtlas; Q8BKY8; -.
DR PRIDE; Q8BKY8; -.
DR ProteomicsDB; 287630; -.
DR Antibodypedia; 1265; 78 antibodies from 20 providers.
DR DNASU; 74238; -.
DR Ensembl; ENSMUST00000050813; ENSMUSP00000062762; ENSMUSG00000049038.
DR GeneID; 74238; -.
DR KEGG; mmu:74238; -.
DR UCSC; uc007gld.2; mouse.
DR CTD; 80298; -.
DR MGI; MGI:1921488; Mterf2.
DR VEuPathDB; HostDB:ENSMUSG00000049038; -.
DR eggNOG; KOG1267; Eukaryota.
DR GeneTree; ENSGT00530000063817; -.
DR HOGENOM; CLU_058644_0_0_1; -.
DR InParanoid; Q8BKY8; -.
DR OMA; LWMSVCP; -.
DR OrthoDB; 1103140at2759; -.
DR PhylomeDB; Q8BKY8; -.
DR TreeFam; TF330821; -.
DR BioGRID-ORCS; 74238; 4 hits in 71 CRISPR screens.
DR PRO; PR:Q8BKY8; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8BKY8; protein.
DR Bgee; ENSMUSG00000049038; Expressed in intercostal muscle and 232 other tissues.
DR ExpressionAtlas; Q8BKY8; baseline and differential.
DR Genevisible; Q8BKY8; MM.
DR GO; GO:0005759; C:mitochondrial matrix; IBA:GO_Central.
DR GO; GO:0042645; C:mitochondrial nucleoid; IDA:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR GO; GO:0003690; F:double-stranded DNA binding; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0006393; P:termination of mitochondrial transcription; IBA:GO_Central.
DR Gene3D; 1.25.70.10; -; 2.
DR InterPro; IPR003690; MTERF.
DR InterPro; IPR038538; MTERF_sf.
DR PANTHER; PTHR15437; PTHR15437; 1.
DR Pfam; PF02536; mTERF; 1.
DR SMART; SM00733; Mterf; 4.
PE 1: Evidence at protein level;
KW Mitochondrion; Mitochondrion nucleoid; Reference proteome; Transcription;
KW Transcription regulation; Transit peptide.
FT TRANSIT 1..35
FT /note="Mitochondrion"
FT /evidence="ECO:0000250|UniProtKB:Q49AM1"
FT CHAIN 36..385
FT /note="Transcription termination factor 2, mitochondrial"
FT /id="PRO_0000255465"
SQ SEQUENCE 385 AA; 43453 MW; AD89067377997417 CRC64;
MPWRLPTGHQ LCRLCLLRKP RPALKIKPSS ACVTYGTDSQ SDKENKRTVE KLSACSVDIR
KIRRLKGWVL LEEETYVEEI ANILKELGAN KTVIASILER CPEAIICSPA AVNTKRKLWQ
MVCKNEAELV QLIEQFPESF FTVKNQENQK LNVQFFQELG LRNVVISRFL TTASSIFHNP
VENNKQMIGV LQESYLNLGG SEANAKVWLL KLLSQNPFIV LHSPRAVGET LKCLQGQGFT
DSEVLQLLSK LKGFLFQLQP GSIQNSISFT KTTFECTDYD LRQLVVKCPA LLCYPASVLE
ERIQALLKEG ISIAQIRESP MVLELTPQII QYRIRKLNSL GYGIKDGHLA SLNGTKKEFE
ANFSKMQAKQ GRPLFNPVAS LKVEE
