MTEF2_RAT
ID MTEF2_RAT Reviewed; 385 AA.
AC Q5XIE2;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Transcription termination factor 2, mitochondrial;
DE AltName: Full=Mitochondrial transcription termination factor 2;
DE Short=mTERF2;
DE AltName: Full=mTERF domain-containing protein 3, mitochondrial;
DE Flags: Precursor;
GN Name=Mterf2; Synonyms=Mterfd3;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart, and Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Binds mitochondrial DNA and plays a role in the regulation of
CC transcription of mitochondrial mRNA and rRNA species.
CC {ECO:0000250|UniProtKB:Q49AM1}.
CC -!- SUBUNIT: Monomer. {ECO:0000250|UniProtKB:Q49AM1}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix, mitochondrion nucleoid
CC {ECO:0000250|UniProtKB:Q8BKY8}.
CC -!- SIMILARITY: Belongs to the mTERF family. {ECO:0000305}.
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DR EMBL; BC083741; AAH83741.1; -; mRNA.
DR EMBL; BC098693; AAH98693.1; -; mRNA.
DR RefSeq; NP_001014287.1; NM_001014265.2.
DR AlphaFoldDB; Q5XIE2; -.
DR SMR; Q5XIE2; -.
DR STRING; 10116.ENSRNOP00000009135; -.
DR PaxDb; Q5XIE2; -.
DR PRIDE; Q5XIE2; -.
DR GeneID; 366856; -.
DR KEGG; rno:366856; -.
DR UCSC; RGD:1311836; rat.
DR CTD; 80298; -.
DR RGD; 1311836; Mterf2.
DR VEuPathDB; HostDB:ENSRNOG00000006978; -.
DR eggNOG; KOG1267; Eukaryota.
DR HOGENOM; CLU_058644_0_0_1; -.
DR InParanoid; Q5XIE2; -.
DR OMA; LWMSVCP; -.
DR OrthoDB; 1103140at2759; -.
DR PhylomeDB; Q5XIE2; -.
DR TreeFam; TF330821; -.
DR PRO; PR:Q5XIE2; -.
DR Proteomes; UP000002494; Chromosome 7.
DR Bgee; ENSRNOG00000006978; Expressed in heart and 19 other tissues.
DR Genevisible; Q5XIE2; RN.
DR GO; GO:0005759; C:mitochondrial matrix; IBA:GO_Central.
DR GO; GO:0042645; C:mitochondrial nucleoid; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; ISO:RGD.
DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR GO; GO:0003690; F:double-stranded DNA binding; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0006393; P:termination of mitochondrial transcription; IBA:GO_Central.
DR Gene3D; 1.25.70.10; -; 1.
DR InterPro; IPR003690; MTERF.
DR InterPro; IPR038538; MTERF_sf.
DR PANTHER; PTHR15437; PTHR15437; 1.
DR Pfam; PF02536; mTERF; 1.
DR SMART; SM00733; Mterf; 4.
PE 2: Evidence at transcript level;
KW Mitochondrion; Mitochondrion nucleoid; Reference proteome; Transcription;
KW Transcription regulation; Transit peptide.
FT TRANSIT 1..35
FT /note="Mitochondrion"
FT /evidence="ECO:0000250|UniProtKB:Q49AM1"
FT CHAIN 36..385
FT /note="Transcription termination factor 2, mitochondrial"
FT /id="PRO_0000255467"
SQ SEQUENCE 385 AA; 43344 MW; 4508A627A8D49F50 CRC64;
MSWRLLTGYQ LCRLRLFRKP QPALKIRPSS VCVTYGTDCQ SNKENKRTVE TLRACSVDIG
KICRLKGWVL LEEETYAEEI ANILKELGAN QTVIASILER CPEAIVCSPA AVNTKRKLWQ
MVCKTKTELI QLIEQFPESF FAVKDQENQK LNVQFFQELG LKNVVITRFL TTASSIFHNP
VENNKQMIGV LLESYLNLGG SEANAKVWLL KLLSQNPFIV LSSPTAVGEV LKFLQGQGFT
DSEVLQLLSK LKGFLFQLQP GSIQNSISFT KTTFECTDHD LRQLVVKCPA LLYYPAPVLE
ERIQALLKEG ISVAQIRASP MVLELTPQII QYRIRKLNSL GYGIKDGHLA SLNGTKKEFE
ANFSKMQAKQ GRPLFNPVAS LKVEE
