MTEF3_MOUSE
ID MTEF3_MOUSE Reviewed; 412 AA.
AC Q8R3J4; Q9CSV1; Q9CWM7;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Transcription termination factor 3, mitochondrial;
DE AltName: Full=Mitochondrial transcription termination factor 3;
DE Short=mTERF3;
DE AltName: Full=mTERF domain-containing protein 1, mitochondrial;
DE Flags: Precursor;
GN Name=Mterf3; Synonyms=Mterfd1; OrderedLocusNames=CGI-12;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryonic stem cell;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and FVB/N-3; TISSUE=Kidney, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP DISRUPTION PHENOTYPE, AND FUNCTION.
RX PubMed=17662942; DOI=10.1016/j.cell.2007.05.046;
RA Park C.B., Asin-Cayuela J., Camara Y., Shi Y., Pellegrini M., Gaspari M.,
RA Wibom R., Hultenby K., Erdjument-Bromage H., Tempst P., Falkenberg M.,
RA Gustafsson C.M., Larsson N.G.;
RT "MTERF3 is a negative regulator of mammalian mtDNA transcription.";
RL Cell 130:273-285(2007).
RN [4]
RP FUNCTION.
RX PubMed=23300484; DOI=10.1371/journal.pgen.1003178;
RA Wredenberg A., Lagouge M., Bratic A., Metodiev M.D., Spaahr H., Mourier A.,
RA Freyer C., Ruzzenente B., Tain L., Groenke S., Baggio F., Kukat C.,
RA Kremmer E., Wibom R., Polosa P.L., Habermann B., Partridge L., Park C.B.,
RA Larsson N.G.;
RT "MTERF3 regulates mitochondrial ribosome biogenesis in invertebrates and
RT mammals.";
RL PLoS Genet. 9:E1003178-E1003178(2013).
CC -!- FUNCTION: Binds promoter DNA and regulates initiation of transcription
CC (By similarity). Required for normal mitochondrial transcription and
CC translation, and for normal assembly of mitochondrial respiratory
CC complexes (PubMed:17662942, PubMed:23300484). Required for normal
CC mitochondrial function (PubMed:17662942, PubMed:23300484). Maintains
CC 16S rRNA levels and functions in mitochondrial ribosome assembly by
CC regulating the biogenesis of the 39S ribosomal subunit
CC (PubMed:17662942, PubMed:23300484). {ECO:0000250|UniProtKB:Q96E29,
CC ECO:0000269|PubMed:17662942, ECO:0000269|PubMed:23300484}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q96E29}.
CC -!- DOMAIN: Contains seven structural repeats of about 35 residues, where
CC each repeat contains three helices. The repeats form a superhelical
CC structure with a solenoid shape. {ECO:0000250|UniProtKB:Q96E29}.
CC -!- DISRUPTION PHENOTYPE: Embryonic lethality, due to severe mitochondrial
CC dysfunction. Embryos are much smaller than normal and none survive past
CC 10.5 dpc. {ECO:0000269|PubMed:17662942}.
CC -!- SIMILARITY: Belongs to the mTERF family. {ECO:0000305}.
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DR EMBL; AK010525; BAB27006.1; -; mRNA.
DR EMBL; AK011934; BAB27924.3; -; mRNA.
DR EMBL; BC025173; AAH25173.1; -; mRNA.
DR EMBL; BC085282; AAH85282.1; -; mRNA.
DR CCDS; CCDS26611.1; -.
DR RefSeq; NP_079823.2; NM_025547.3.
DR RefSeq; XP_006517384.1; XM_006517321.2.
DR RefSeq; XP_011242850.1; XM_011244548.2.
DR RefSeq; XP_017171052.1; XM_017315563.1.
DR AlphaFoldDB; Q8R3J4; -.
DR SMR; Q8R3J4; -.
DR STRING; 10090.ENSMUSP00000021991; -.
DR iPTMnet; Q8R3J4; -.
DR PhosphoSitePlus; Q8R3J4; -.
DR EPD; Q8R3J4; -.
DR MaxQB; Q8R3J4; -.
DR PaxDb; Q8R3J4; -.
DR PeptideAtlas; Q8R3J4; -.
DR PRIDE; Q8R3J4; -.
DR ProteomicsDB; 286072; -.
DR Antibodypedia; 1268; 63 antibodies from 21 providers.
DR DNASU; 66410; -.
DR Ensembl; ENSMUST00000021991; ENSMUSP00000021991; ENSMUSG00000021519.
DR GeneID; 66410; -.
DR KEGG; mmu:66410; -.
DR UCSC; uc007qzw.2; mouse.
DR CTD; 51001; -.
DR MGI; MGI:1913660; Mterf3.
DR VEuPathDB; HostDB:ENSMUSG00000021519; -.
DR eggNOG; KOG1267; Eukaryota.
DR GeneTree; ENSGT00390000005801; -.
DR HOGENOM; CLU_042536_0_0_1; -.
DR InParanoid; Q8R3J4; -.
DR OMA; PRLMMIP; -.
DR OrthoDB; 1294087at2759; -.
DR PhylomeDB; Q8R3J4; -.
DR TreeFam; TF317943; -.
DR BioGRID-ORCS; 66410; 18 hits in 72 CRISPR screens.
DR ChiTaRS; Mterf3; mouse.
DR PRO; PR:Q8R3J4; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q8R3J4; protein.
DR Bgee; ENSMUSG00000021519; Expressed in medial ganglionic eminence and 259 other tissues.
DR ExpressionAtlas; Q8R3J4; baseline and differential.
DR Genevisible; Q8R3J4; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR GO; GO:0061668; P:mitochondrial ribosome assembly; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:UniProtKB.
DR Gene3D; 1.25.70.10; -; 1.
DR InterPro; IPR003690; MTERF.
DR InterPro; IPR038538; MTERF_sf.
DR PANTHER; PTHR13068; PTHR13068; 1.
DR Pfam; PF02536; mTERF; 1.
DR SMART; SM00733; Mterf; 6.
PE 2: Evidence at transcript level;
KW DNA-binding; Mitochondrion; Reference proteome; Ribosome biogenesis;
KW Transcription; Transcription regulation; Transit peptide.
FT TRANSIT 1..67
FT /note="Mitochondrion"
FT /evidence="ECO:0000250|UniProtKB:Q96E29"
FT CHAIN 68..412
FT /note="Transcription termination factor 3, mitochondrial"
FT /id="PRO_0000255458"
FT CONFLICT 201..203
FT /note="GPF -> DTY (in Ref. 1; BAB27006)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 412 AA; 47357 MW; E85FAACAA83E1C59 CRC64;
MALLAQQLPR RFNSVKLTSF IKAKQVTKRS ARAGKAVLPG FSAQPLLSSD TSFLRRGIKT
YRTLFWNRFH SASTNRTKSS AESTLLPSVA EQQERILSLE SELPLEEVDD LPPLSPLQSV
SEEEAIQIAA YSPLPISSFT LADYVDHSKT LQKLVQLGVD LSKIEKHPDA ANLLLRLDFE
KHIKQILLFL KDLGLEDNQL GPFLTKNYAI FSEDLENLKT RVAYLQSKNF SKTDIARMVK
NAPFLLSFSV ERLDNRLGFF QKELELNVKK TRDLVVRLPR LLTGSLEPVK ENMKVYHLEL
GFKHNEIQHM VIKIPKMLTA NKRKLTEIFD YVHNVMNIPH HIIVKFPQLF NTRVFKIKER
HLFLAYLGRA QYDPAKPNYV SLDKFVSFPD KIFCKEIAKA SLNDFEKFLK TL
