ID   MTEF3_RAT               Reviewed;         409 AA.
AC   Q6P6Q6;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Transcription termination factor 3, mitochondrial;
DE   AltName: Full=Mitochondrial transcription termination factor 3;
DE            Short=mTERF3;
DE   AltName: Full=mTERF domain-containing protein 1, mitochondrial;
DE   Flags: Precursor;
GN   Name=Mterf3; Synonyms=Mterfd1; OrderedLocusNames=CGI-12;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Binds promoter DNA and regulates initiation of transcription.
CC       Required for normal mitochondrial transcription and translation, and
CC       for normal assembly of mitochondrial respiratory complexes. Required
CC       for normal mitochondrial function. Maintains 16S rRNA levels and
CC       functions in mitochondrial ribosome assembly by regulating the
CC       biogenesis of the 39S ribosomal subunit (By similarity).
CC       {ECO:0000250|UniProtKB:Q8R3J4, ECO:0000250|UniProtKB:Q96E29}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q96E29}.
CC   -!- DOMAIN: Contains seven structural repeats of about 35 residues, where
CC       each repeat contains three helices. The repeats form a superhelical
CC       structure with a solenoid shape (By similarity).
CC       {ECO:0000250|UniProtKB:Q96E29}.
CC   -!- SIMILARITY: Belongs to the mTERF family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC062080; AAH62080.1; -; mRNA.
DR   RefSeq; NP_955419.1; NM_199387.1.
DR   AlphaFoldDB; Q6P6Q6; -.
DR   SMR; Q6P6Q6; -.
DR   STRING; 10116.ENSRNOP00000006185; -.
DR   PhosphoSitePlus; Q6P6Q6; -.
DR   PaxDb; Q6P6Q6; -.
DR   PRIDE; Q6P6Q6; -.
DR   Ensembl; ENSRNOT00000006185; ENSRNOP00000006185; ENSRNOG00000004492.
DR   GeneID; 299514; -.
DR   KEGG; rno:299514; -.
DR   UCSC; RGD:735158; rat.
DR   CTD; 51001; -.
DR   RGD; 735158; Mterf3.
DR   eggNOG; KOG1267; Eukaryota.
DR   GeneTree; ENSGT00390000005801; -.
DR   HOGENOM; CLU_042536_0_0_1; -.
DR   InParanoid; Q6P6Q6; -.
DR   OMA; PRLMMIP; -.
DR   OrthoDB; 1294087at2759; -.
DR   PhylomeDB; Q6P6Q6; -.
DR   PRO; PR:Q6P6Q6; -.
DR   Proteomes; UP000002494; Chromosome 7.
DR   Bgee; ENSRNOG00000004492; Expressed in kidney and 20 other tissues.
DR   Genevisible; Q6P6Q6; RN.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR   GO; GO:0061668; P:mitochondrial ribosome assembly; IBA:GO_Central.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   Gene3D; 1.25.70.10; -; 1.
DR   InterPro; IPR003690; MTERF.
DR   InterPro; IPR038538; MTERF_sf.
DR   PANTHER; PTHR13068; PTHR13068; 1.
DR   Pfam; PF02536; mTERF; 1.
DR   SMART; SM00733; Mterf; 6.
PE   2: Evidence at transcript level;
KW   Mitochondrion; Reference proteome; Ribosome biogenesis; Transcription;
KW   Transcription regulation; Transit peptide.
FT   TRANSIT         1..64
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000250|UniProtKB:Q96E29"
FT   CHAIN           65..409
FT                   /note="Transcription termination factor 3, mitochondrial"
FT                   /id="PRO_0000255459"
FT   REGION          74..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   409 AA;  46666 MW;  CD2EE4B649D38006 CRC64;
     MALLAQQLSR WFNSVKLSSF IKATQVTKHS AGLGKNASAQ ALLSSDTCFL QWGIKTDRAL
     FSWSSFQSAN TTRRKSSTNS TLLPSVSEQP EKIPRLESEL PLEELDDLPP LSPLQPVSEE
     EAIQIAAYSP LPLSSSTLAD YVDHSETLQK LVQLGVDLSK IEKHPDVANL LLRLNFEKDI
     KQILLFLKDL GLEDNQLGPF LTKNYAIFSE DLENLKTRVA YLQSKNFSKT DIACMVKNAP
     FLLSFSVERL DNRLGFFQKE LELSVKKTRD LVVRLPRLLT GSLEPVKENM KVYRLELGFK
     HNEIQHMVTK IPKMLTANKR KLTETFDYVH NVMNIPHHII VKFPQVFNTR VFKIKERHLF
     LAYLGKAQYD PAKPNYVSLD KFVSFPDEVF CKEIAKASVN DFEKFLKTL