ID   MTEF4_RAT               Reviewed;         347 AA.
AC   Q4G078;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Transcription termination factor 4, mitochondrial;
DE   AltName: Full=Mitochondrial transcription termination factor 4;
DE   AltName: Full=mTERF domain-containing protein 2;
DE   Flags: Precursor;
GN   Name=Mterf4; Synonyms=Mterfd2; OrderedLocusNames=HSPC096;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Regulator of mitochondrial ribosome biogenesis and
CC       translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S and
CC       targets NSUN4 RNA methyltransferase to the mitochondrial large
CC       ribosomal subunit (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer with NSUN4; this interaction may be required for
CC       NSUN4 recruitment to the mitochondrial large ribosomal subunit.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- DOMAIN: The MTERF repeats form a half-donut shaped, right-handed
CC       superhelix, where the concave side displays a positively charged path
CC       for nucleic acid interaction. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the mTERF family. {ECO:0000305}.
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DR   EMBL; BC098676; AAH98676.1; -; mRNA.
DR   RefSeq; NP_001032286.1; NM_001037209.1.
DR   AlphaFoldDB; Q4G078; -.
DR   SMR; Q4G078; -.
DR   STRING; 10116.ENSRNOP00000053397; -.
DR   PaxDb; Q4G078; -.
DR   Ensembl; ENSRNOT00000056558; ENSRNOP00000053397; ENSRNOG00000037376.
DR   GeneID; 363289; -.
DR   KEGG; rno:363289; -.
DR   UCSC; RGD:1562440; rat.
DR   CTD; 130916; -.
DR   RGD; 1562440; Mterf4.
DR   eggNOG; ENOG502RXUW; Eukaryota.
DR   GeneTree; ENSGT00460000041648; -.
DR   HOGENOM; CLU_069384_1_0_1; -.
DR   InParanoid; Q4G078; -.
DR   OMA; TNKNVWK; -.
DR   OrthoDB; 1431133at2759; -.
DR   PhylomeDB; Q4G078; -.
DR   TreeFam; TF329452; -.
DR   PRO; PR:Q4G078; -.
DR   Proteomes; UP000002494; Chromosome 9.
DR   Bgee; ENSRNOG00000037376; Expressed in liver and 19 other tissues.
DR   Genevisible; Q4G078; RN.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005762; C:mitochondrial large ribosomal subunit; ISO:RGD.
DR   GO; GO:0005739; C:mitochondrion; ISO:RGD.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:InterPro.
DR   GO; GO:0019843; F:rRNA binding; ISO:RGD.
DR   GO; GO:0043010; P:camera-type eye development; ISO:RGD.
DR   GO; GO:0007507; P:heart development; ISO:RGD.
DR   GO; GO:0006390; P:mitochondrial transcription; ISO:RGD.
DR   GO; GO:0006626; P:protein targeting to mitochondrion; ISO:RGD.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0042255; P:ribosome assembly; ISO:RGD.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.70.10; -; 1.
DR   InterPro; IPR003690; MTERF.
DR   InterPro; IPR038538; MTERF_sf.
DR   PANTHER; PTHR13068; PTHR13068; 1.
DR   Pfam; PF02536; mTERF; 1.
DR   SMART; SM00733; Mterf; 4.
PE   2: Evidence at transcript level;
KW   Mitochondrion; Reference proteome; Repeat; RNA-binding; rRNA processing;
KW   Transit peptide.
FT   TRANSIT         1..42
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000250"
FT   CHAIN           43..347
FT                   /note="Transcription termination factor 4, mitochondrial"
FT                   /id="PRO_0000255463"
FT   REPEAT          142..172
FT                   /note="MTERF 1"
FT   REPEAT          177..204
FT                   /note="MTERF 2"
FT   REPEAT          209..239
FT                   /note="MTERF 3"
FT   REPEAT          245..270
FT                   /note="MTERF 4"
FT   REPEAT          290..318
FT                   /note="MTERF 5"
FT   REGION          310..327
FT                   /note="Dimerization with NSUN4"
FT                   /evidence="ECO:0000250"
FT   REGION          321..347
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        326..347
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   347 AA;  40381 MW;  FAD323DACE78CDA1 CRC64;
     MASLGRQVPE WHRLMALSWA CLARQTCHFR KEKKMSPSLF CKLTTVPSRG NFQEFSSVRP
     KKYMQEPEHR TRLVPCLHEE QRTCMGSESL ELERAISSLQ DMGFAEAHID SLLNIQPSVH
     PQQLLDIISE LLLLGLNPEP VFMALKKNPQ LLKLSATQMK RRSSYLRKLG LGEGKLKRVL
     SVCPKVFTMR QQDIDNIVKV LKEKCLFTVQ HITDILHRCP AVLQEDPSEL EYKFQYAYFR
     MGLTHLDIVR TDFLQYSIAK VKQRHIYLER LGRYQTPDKK GQTQIPNPSL KNILRVSEAE
     FLARTACSSA EEFEVFKKLL DQEEEESESH MSEEEEEEEE EEEEELP