MTEF6_ARATH
ID MTEF6_ARATH Reviewed; 333 AA.
AC Q9SZL6;
DT 11-MAY-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 132.
DE RecName: Full=Transcription termination factor MTERF6, chloroplastic/mitochondrial {ECO:0000305};
DE AltName: Full=Mitochondrial transcription termination factor 6 {ECO:0000303|PubMed:23087700};
DE AltName: Full=Protein PIGMENT DEFECTIVE 191 {ECO:0000305};
DE Flags: Precursor;
GN Name=MTERF6 {ECO:0000303|PubMed:23087700}; Synonyms=PDE191 {ECO:0000305};
GN OrderedLocusNames=At4g38160 {ECO:0000312|Araport:AT4G38160};
GN ORFNames=F20D10.280 {ECO:0000312|EMBL:CAB37556.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP SUBCELLULAR LOCATION.
RX PubMed=21464319; DOI=10.1073/pnas.1103442108;
RA Babiychuk E., Vandepoele K., Wissing J., Garcia-Diaz M., De Rycke R.,
RA Akbari H., Joubes J., Beeckman T., Jaensch L., Frentzen M.,
RA Van Montagu M.C., Kushnir S.;
RT "Plastid gene expression and plant development require a plastidic protein
RT of the mitochondrial transcription termination factor family.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:6674-6679(2011).
RN [5]
RP GENE FAMILY.
RX PubMed=23087700; DOI=10.3389/fpls.2012.00233;
RA Kleine T.;
RT "Arabidopsis thaliana mTERF proteins: evolution and functional
RT classification.";
RL Front. Plant Sci. 3:233-233(2012).
RN [6]
RP FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RX PubMed=26152711; DOI=10.1104/pp.15.00964;
RA Romani I., Manavski N., Morosetti A., Tadini L., Maier S., Kuehn K.,
RA Ruwe H., Schmitz-Linneweber C., Wanner G., Leister D., Kleine T.;
RT "A member of the Arabidopsis mitochondrial transcription termination factor
RT family is required for maturation of chloroplast transfer RNAIle(GAU).";
RL Plant Physiol. 169:627-646(2015).
CC -!- FUNCTION: Transcription termination factor essential for chloroplast
CC development. Required for maturation of 16S rRNA, 18S rRNA and 23S rRNA
CC in the chloroplast. Binds to a specific region within the
CC tRNA(Ile)(GAU) gene at a position adjacent to and downstream of the 16S
CC rRNA gene. Required for the maturation of tRNA(Ile)(GAU). Binds to
CC double-stranded DNA.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast
CC {ECO:0000269|PubMed:26152711}. Mitochondrion
CC {ECO:0000269|PubMed:21464319, ECO:0000269|PubMed:26152711}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences. {ECO:0000305};
CC Name=1;
CC IsoId=Q9SZL6-1; Sequence=Displayed;
CC -!- DISRUPTION PHENOTYPE: Small white seeds, with defective choloroplasts,
CC that are unable to germinate on soil. Albino seedlings that die rapidly
CC when grown on synthetic medium. {ECO:0000269|PubMed:26152711}.
CC -!- SIMILARITY: Belongs to the mTERF family. {ECO:0000305}.
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DR EMBL; AL035538; CAB37556.1; -; Genomic_DNA.
DR EMBL; AL161593; CAB80481.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE86886.1; -; Genomic_DNA.
DR EMBL; CP002687; ANM66664.1; -; Genomic_DNA.
DR EMBL; AY093769; AAM10391.1; -; mRNA.
DR EMBL; BT000548; AAN18117.1; -; mRNA.
DR PIR; T05643; T05643.
DR RefSeq; NP_001320159.1; NM_001342483.1. [Q9SZL6-1]
DR RefSeq; NP_195529.1; NM_119977.5. [Q9SZL6-1]
DR AlphaFoldDB; Q9SZL6; -.
DR SMR; Q9SZL6; -.
DR STRING; 3702.AT4G38160.3; -.
DR PaxDb; Q9SZL6; -.
DR DNASU; 829972; -.
DR EnsemblPlants; AT4G38160.1; AT4G38160.1; AT4G38160. [Q9SZL6-1]
DR EnsemblPlants; AT4G38160.4; AT4G38160.4; AT4G38160. [Q9SZL6-1]
DR GeneID; 829972; -.
DR Gramene; AT4G38160.1; AT4G38160.1; AT4G38160. [Q9SZL6-1]
DR Gramene; AT4G38160.4; AT4G38160.4; AT4G38160. [Q9SZL6-1]
DR KEGG; ath:AT4G38160; -.
DR Araport; AT4G38160; -.
DR eggNOG; KOG1267; Eukaryota.
DR HOGENOM; CLU_044150_0_0_1; -.
DR OMA; EPRMKFL; -.
DR PhylomeDB; Q9SZL6; -.
DR PRO; PR:Q9SZL6; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9SZL6; baseline and differential.
DR GO; GO:0009507; C:chloroplast; IDA:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
DR GO; GO:0003690; F:double-stranded DNA binding; IDA:UniProtKB.
DR GO; GO:0003723; F:RNA binding; IDA:UniProtKB.
DR GO; GO:0009658; P:chloroplast organization; IBA:GO_Central.
DR GO; GO:0032502; P:developmental process; IBA:GO_Central.
DR GO; GO:0006353; P:DNA-templated transcription, termination; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0008033; P:tRNA processing; IMP:UniProtKB.
DR Gene3D; 1.25.70.10; -; 1.
DR InterPro; IPR003690; MTERF.
DR InterPro; IPR038538; MTERF_sf.
DR PANTHER; PTHR13068; PTHR13068; 1.
DR Pfam; PF02536; mTERF; 1.
DR SMART; SM00733; Mterf; 7.
PE 2: Evidence at transcript level;
KW Alternative splicing; Chloroplast; DNA-binding; Mitochondrion; Plastid;
KW Reference proteome; RNA-binding; Transcription; Transcription regulation;
KW Transcription termination; Transit peptide.
FT TRANSIT 1..?
FT /note="Chloroplast and mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..333
FT /note="Transcription termination factor MTERF6,
FT chloroplastic/mitochondrial"
FT /id="PRO_0000436199"
SQ SEQUENCE 333 AA; 37888 MW; 1BBFE8551BD16EEE CRC64;
MEVTNTSSIM WFFRDKGFDD PSIDKMLRKC KQLEKAQSDV ASENWDYLSN IVGIQERKLP
YIVSRCPKIL TLRLDERLIP MVECLSSLGR NPREVASAIT KFPPILSHSV EEKLCPLLAF
FQALGVPETQ LGKMILFNPR LISYSIDTKL TVIVSFLASL GLDQDGMIGK VLVKNPFLMG
YSVDKRLRPT TEFLKSSVGL SEDGIKSVVM NFPQLLCRDV NKILKPNYDY LKECGFGDSQ
IATMVTGYPQ ILIKSVKNSL QPRIRFLVQV MGRGMDEVAS YPEFFHHGLK KKVESRFKLV
KKNNIDCSLR EMLDCNTKKF HEKFGFSEVT ASF
